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Facilitating permeability of landscapes impacted by roads for protected amphibians
Amphibian populations are highly vulnerable to road mortality and habitat fragmentation caused by road networks. Wildlife road tunnels are considered the most promising road mitigation measure for amphibians yet generally remain...
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Trends in therapeutic drug conjugates for bacterial diseases
INTRODUCTION: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted...
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Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209 + dendritic cells for immune T cell areas
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into...
Published by: Rockefeller University
Development of vocal emotion recognition in school-age children
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
Published by: PeerJ
A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging.
We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal decaging. This was enabled by a thioether binding motif in the propargyl...
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Development of vocal emotion recognition in school-age children
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
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Anterior mitral valve leaflet length in cats with hypertrophic cardiomyopathy.
INTRODUCTION: Anterior mitral valve leaflet (AMVL) elongation is a recognised feature of hypertrophic cardiomyopathy (HCM). However, whether AMVL elongation precedes left ventricular hypertrophy in cats is currently unknown. The...
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Sequential dual site-selective protein labelling enabled by lysine modification.
Methods that allow for chemical site-selective dual protein modification are scarce. Here, we provide proof-of-concept for the orthogonality and compatibility of a method for regioselective lysine modification with strategies...
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Comparison of Normalization Techniques on Data Sets With Outliers
With the fast growth of data-rich systems, dealing with complex decision problems with skewed input data sets and respective outliers is unavoidable. Generally, data skewness refers to a non-uniform distribution in a dataset...
Temperature response of an all-solid photonic bandgap fiber for sensing applications
The spectral shift due to temperature in the photonic bandgap (PBG) of an all-solid PBG fiber is investigated, aiming at discrete and distributed temperature sensing. A temperature rise induces a red shift in the bandgap...
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Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity
Efficient vaccination against the parasite Leishmania major, the causative agent of human cutaneous leishmaniasis, requires development of type 1 T-helper (Th1) CD4+ T cell immunity. Because of their unique capacity to initiate...
Published by: Rockefeller University
Temperature response of an all-solid photonic bandgap fiber for sensing applications
The spectral shift due to temperature in the photonic bandgap (PBG) of an all-solid PBG fiber is investigated, aiming at discrete and distributed temperature sensing. A temperature rise induces a red shift in the bandgap...
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Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
Quaternized vinyl- and alkynyl-pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine-tagged proteins at near-stoichiometric quantities. We have demonstrated that this method can...
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Profiling IT Security and Interoperability in Brazilian Health Organisations From a Business Perspective
The proliferation of electronic health (e-Health) initiatives in Brazil over the last 2 decades has resulted in a considerable fragmentation within health information technology (IT), with a strong political interference. The...
Chemo- and Regioselective Lysine Modification on Native Proteins.
Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site...
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