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LHC and B physics probes of neutrinoless double beta decay in supersymmetry without R-parity
In the event of an observation of neutrinoless double beta decay, a relevant
question would be: what lepton number violating physics is responsible for the
decay? The exchange of Majorana neutrinos and/or supersymmetric...
Large hadron collider probe of supersymmetric neutrinoless double-beta-decay mechanism.
In the minimal supersymmetric extension to the standard model, a nonzero lepton number violating coupling lambda(111);(') predicts both neutrinoless double-beta-decay and resonant single slepton production at the LHC. We show...
'The Additional Attraction of Affliction'
CH Walker-Gore
Apr 28, 2017
WHILE THERE IS NEVER any serious doubt that Mr. Arabin, clergyman hero of Anthony Trollope’s Barchester Towers (1857), is destined to marry our heroine, Eleanor Bold, there are moments in the novel when he is all but overcome by...
Synthesis, characterisation and crystal structure of [(CH<sub>3</sub>)<sub>2</sub>CH]<sub>2</sub>NH<sub>2</sub>(PhPO<sub>3</sub>H)<sub>2</sub>SnPh<sub>3</sub>
The title compound, [(CH)CH]NH ·[(PhPOH)SnPh]-, has been synthesised and its structure determined by spectroscopies (IR, RMN and Mössbauer) and single crystal X-ray crystallography. The Mössbauer spectroscopy data for the title...
Synthesis, characterisation and crystal structure of [(CH<sub>3</sub>)<sub>2</sub>CH]<sub>2</sub>NH<sub>2</sub>(PhPO<sub>3</sub>H)<sub>2</sub>SnPh<sub>3</sub>
The title compound, [(CH)CH]NH ·[(PhPOH)SnPh]-, has been synthesised and its structure determined by spectroscopies (IR, RMN and Mössbauer) and single crystal X-ray crystallography. The Mössbauer spectroscopy data for the title...
Near-room-temperature reversible giant barocaloric effects in [(CH<inf>3</inf>)<inf>4</inf>N]Mn[N<inf>3</inf>]<inf>3</inf>hybrid perovskite
J Salgado-Beceiro, A Nonato, RX Silva, A García-Fernández, M Sánchez-Andújar, S Castro-García, E Stern-Taulats, MA Señarís-Rodríguez, X Moya, JM Bermúdez-García
Dec 07, 2020
We report giant reversible barocaloric effects in [(CH3)4N]Mn[N3]3 hybrid organic–inorganic perovskite, near its first-order cubic-monoclinic structural phase transition at...
Phonon anharmonicity, lifetimes, and thermal transport in CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> from many-body perturbation theory
Lattice vibrations in CH3NH3PbI3 are strongly interacting, with double-well instabilities present at the Brillouin zone boundary. Analysis within a first-principles lattice-dynamics framework...
Selective trimerisation and polymerisation of ethylene
Randolf Kohn, Alexander G N Coxon, Christopher R. Hawkins, David Smith, Shahram Mihan, Katrin Schuhen, Michael Schiendorfer, Gabriele Kociok-Köhn
Dec 14, 2014
A range of triazacyclohexane (R3TAC) complexes of CrCl3 with unsaturated N-substituents R have been prepared. The complexes with R = allyl (3f) and CH2CH(CH2CH =...
Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey.
Richard P Allen, Brendan J Burchell, Ben MacDonald, Wayne A Hening, Christopher J Earley
Apr 15, 2012
BACKGROUND AND PURPOSE: Epidemiological studies of restless legs syndrome (RLS) have been limited by lack of a well validated patient-completed diagnostic questionnaire that has a high enough specificity to provide a reasonable...
Phonon anharmonicity, lifetimes, and thermal transport in CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> from many-body perturbation theory
Lattice vibrations in CH3NH3PbI3 are strongly interacting, with double-well instabilities present at the Brillouin zone boundary. Analysis within a first-principles lattice-dynamics framework...
Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism
Z Aycan, H Cangul, M Muzza, VN Bas, L Fugazzola, VK Chatterjee, L Persani, N Schoenmakers
Aug 01, 2017
Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the TPO-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result in...
Halogen effects on ordering and bonding of CH<sub>3</sub>NH<sub>3</sub> <sup>+</sup> in CH<sub>3</sub>NH<sub>3</sub>PbX<sub>3</sub> (X = Cl, Br, I) hybrid perovskites
Ralf G. Niemann, Athanassios G. Kontos, Dimitrios Palles, Efstratios I. Kamitsos, Andreas Kaltzoglou, Federico Brivio, Polycarpos Falaras, Petra J. Cameron
Feb 11, 2016
This study reports Raman and infrared spectra of hybrid organic-inorganic MAPbX3 perovskites (MA = CH3NH3, X = Cl, Br, I) and their mixed-halide derivatives. Raman spectra were recorded at...
Halogen effects on ordering and bonding of CH<sub>3</sub>NH<sub>3</sub> <sup>+</sup> in CH<sub>3</sub>NH<sub>3</sub>PbX<sub>3</sub> (X = Cl, Br, I) hybrid perovskites
Ralf G. Niemann, Athanassios G. Kontos, Dimitrios Palles, Efstratios I. Kamitsos, Andreas Kaltzoglou, Federico Brivio, Polycarpos Falaras, Petra J. Cameron
Feb 11, 2016
This study reports Raman and infrared spectra of hybrid organic-inorganic MAPbX3 perovskites (MA = CH3NH3, X = Cl, Br, I) and their mixed-halide derivatives. Raman spectra were recorded at...
Computational Modeling of a Caged Methyl Cation
DFT calculations for CH3 + within a constrained cage of water molecules permit the controlled manipulation of distances rax and req to "axial" and "equatorial" waters. Equatorial...
Home and away
CH is the disproportionate clonal expansion of blood stem cells and their progeny driven by leukemia-associated somatic mutations and is associated with an increased risk of hematologic cancers and ischemic cardiovascular...
Establishing risk factors and outcomes for congenital hypothyroidism with gland in situ using population-based data linkage methods
Milagros Ruiz Nishiki, Melissa Cabecinha, Rachel Knowles, Catherine Peters, Helen Aitkenhead, Adeboye Ifederu, Nadia Schoenmakers, Neil J Sebire, Erin Walker, Pia Hardelid
Apr 01, 2022
INTRODUCTION: There has been an increase in the birth prevalence of congenital hypothyroidism (CH) since the introduction of newborn screening, both globally and in the UK. This increase can be accounted for by an increase in CH...
Selective trimerisation and polymerisation of ethylene
Randolf Kohn, Alexander G N Coxon, Christopher R. Hawkins, David Smith, Shahram Mihan, Katrin Schuhen, Michael Schiendorfer, Gabriele Kociok-Köhn
Dec 14, 2014
A range of triazacyclohexane (R3TAC) complexes of CrCl3 with unsaturated N-substituents R have been prepared. The complexes with R = allyl (3f) and CH2CH(CH2CH =...
Concordance for clonal hematopoiesis is limited in elderly twins.
Margarete A Fabre, Thomas McKerrell, Maximillian Zwiebel, MS Vijayabaskar, Naomi Park, Philippa M Wells, Roland Rad, Panagiotis Deloukas, Kerrin Small, Claire J Steves, George S Vassiliou
Dec 17, 2019
Although acquisition of leukemia-associated somatic mutations by 1 or more hematopoietic stem cells is inevitable with advancing age, its consequences are highly variable, ranging from clinically silent clonal hematopoiesis (CH)...
Computational Modeling of a Caged Methyl Cation
DFT calculations for CH3 + within a constrained cage of water molecules permit the controlled manipulation of distances rax and req to "axial" and "equatorial" waters. Equatorial...
Dissecting the stability of Atezolizumab with renewable amino acid-based ionic liquids
Bayan Alkhawaja, Faisal Al-Akayleh, Zaid Al-Rubaye, Ghayda' AlDabet, Muna Bustami, Maisa’a Smairat, Ahmed S.A.A. Agha, Jehad Nasereddin, Nidal Qinna, Andreas Michael, Andrew Watts
Jun 30, 2024
Monoclonal antibodies (mAbs) have revolutionised the biopharmaceutical market. Being proteinaceous, mAbs are prone to chemical and physical instabilities. Various approaches were attempted to stabilise proteins against...
Amino acid-based ILs Atezolizumab Biocompatible and renewable ILs Deep Eutectic Solvents Ionic Liquids Stability of monoclonal antibodies /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1315 name=Structural Biology /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
DIAGNOSIS OF ENDOCRINE DISEASE: Congenital hypothyroidism
Congenital hypothyroidism (CH) may be primary, due to a defect affecting the thyroid gland itself, or central, due to impaired thyroid-stimulating hormone (TSH)-mediated stimulation of the thyroid gland as a result of...
Cs<sup>+</sup> incorporation into CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> perovskite
Ralf G. Niemann, Laxman Gouda, Jiangang Hu, Shay Tirosh, Ronen Gottesman, Petra J. Cameron, Arie Zaban
Dec 07, 2016
In this study we systematically explored the mixed cation perovskite Csx(CH3NH3)1-xPbI3. We exchanged the A-site cation by dipping MAPbI3 films into a CsI...
Prednisolone therapy for chronic hepatitis in English springer spaniels
BACKGROUND: English springer spaniels (ESS) show an increased risk of chronic hepatitis (CH). In a previous study of 68 ESS with CH, in which only one dog received corticosteroids, a median survival time of 189 days was noted....
Clonal hematopoiesis and therapy-related myeloid neoplasms following neuroblastoma treatment.
Tim HH Coorens, Grace Collord, Wanhua Lu, Emily Mitchell, Jannat Ijaz, Thomas Roberts, Thomas RW Oliver, GA Amos Burke, Michael Gattens, Emmy Dickens, Jyoti Nangalia, Marc Tischkowitz, John Anderson, Adam Shlien, Anna L Godfrey, Matthew J Murray, Sam Behjati
Feb 05, 2021
Therapy-related myeloid neoplasms (TMN) constitute one of the most challengingcomplications of cancer treatment.1 Whilst understanding of TMN pathogenesis remains fragmentary, genomic studies in adults have thus far refuted the...
Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
Kelly L Bolton, Ryan N Ptashkin, Teng Gao, Lior Braunstein, Sean M Devlin, Daniel Kelly, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine C Coombs, Nicole M Caltabellotta, Mike Walsh, Kenneth Offit, Zsofia Stadler, Diana Mandelker, Jessica Schulman, Akshar Patel, John Philip, Elsa Bernard, Gunes Gundem, Juan E Arango Ossa, Max Levine, Juan S Medina Martinez, Noushin Farnoud, Dominik Glodzik, Sonya Li, Mark E Robson, Choonsik Lee, Paul DP Pharoah, Konrad H Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J Gibson, Benjamin L Ebert, Andrew L Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David M Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia M Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria E Arcila, Marc Ladanyi, David B Solit, Michael F Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis A Diaz, Ross L Levine, Lindsay M Morton, Ahmet Zehir, Elli Papaemmanuil
Jun 02, 2021
Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal...
Humans Neoplasms Leukemia Myeloid Neoplasms Second Primary Cell Transformation Neoplastic Antineoplastic Agents Cohort Studies Mutation Models Biological Adolescent Adult Aged Aged 80 and over Middle Aged Child Child Preschool Infant Infant Newborn Female Male Young Adult selection Genetic Genetic Fitness Clonal Evolution clonal hematopoiesis
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