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Why Study Philo $\textit{Today}$? A Hundred Years of Philonic Scholarship in Retrospect and Prospect
CI Katsos
Jan 24, 2017
The relation of philosophy to theology is notoriously ambiguous. Reading Philo of Alexandria is a case in point. Understanding the dynamics of philosophy and theology in the Philonic corpus is a key to understanding Philo's...
Safety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch
Angus H Forster, Katey Witham, Alexandra CI Depelsenaire, Margaret Veitch, James W Wells, Adam Wheatley, Melinda Pryor, Jason D Lickliter, Barbara Francis, Steve Rockman, Jesse Bodle, Peter Treasure, Julian Hickling, Germain JP Fernando
Apr 14, 2020
BACKGROUND: The Vaxxas high-density microarray patch (HD-MAP) consists of a high density of microprojections coated with vaccine for delivery into the skin. Microarray patches (MAPs) offer the possibility of improved vaccine...
Administration Cutaneous Adolescent Adult Antibodies Viral Australia Cells Cultured Drug Stability Female Humans Immunogenicity Vaccine Immunoglobulin A Influenza A virus H1N1 Subtype Influenza Vaccines Influenza Human Injections Intramuscular Male Saliva T-Lymphocytes Time Factors Transdermal Patch Treatment Outcome Vaccination Young Adult
The politics and fantasy of the gambling education discourse
BACKGROUND: The provision of commercialised gambling products and services has changed radically in recent decades. Gambling is now provided in many places by multi-national corporations, with important implications for public...
Dark Nudges and Sludge in Big Alcohol
Policy Points Nudges steer people toward certain options but also allow them to go their own way. ?Dark nudges? aim to change consumer behavior against their best interests. ?Sludge? uses cognitive biases to make behavior change...
Exploring the Lived Experiences of African American and Latinx STEM Faculty and Students in the U.S.
Racialized faculty have been under-represented in U.S. institutions of higher education for decades and this is exacerbated in STEM disciplines with gender disproportionality. This study deployed a descriptive phenomenological...
Published by: IGI Global Scientific Publishing
An X-ray magnetic circular dichroism (XMCD) study of Fe ordering in a synthetic MgAl<inf>2</inf>O<inf>4</inf>-Fe<inf>3</inf>O<inf>4</inf> (spinel-magnetite) solid-solution series
MgAl2O4-Fe3O4 spinel solid solutions Fe L-2 L-3 X-ray absorption spectroscopy Fe L-2 L-3 X-ray magnetic circular dichroism Mg and Fe K-edge extended X-ray absorption fine structure spectroscopy octahedral and tetrahedral site occupancies calculated unit-cell parameters calculated magnetic moments spinel-magnetite solves hypothetical high-temperature ordering model
Spin Purification in Full-CI Quantum Monte Carlo via a First-Order Penalty Approach.
In this article, we demonstrate that a first-order spin penalty scheme can be efficiently applied to the Slater determinant based Full-CI Quantum Monte Carlo (FCIQMC) algorithm, as a practical route toward spin purification. Two...
Dark Nudges and Sludge in Big Alcohol
Policy Points Nudges steer people toward certain options but also allow them to go their own way. ?Dark nudges? aim to change consumer behavior against their best interests. ?Sludge? uses cognitive biases to make behavior change...
Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time.
SF Garner, A Furnell, BC Kahan, CI Jones, A Attwood, P Harrison, AM Kelly, AH Goodall, R Cardigan, WH Ouwehand
Jul 26, 2019
BACKGROUND AND OBJECTIVES: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that...
Focal Mechanism Analysis of the Earthquakes Beneath the Sunda-Banda Arc Transition, Indonesia, Using the BMKG Data
Abstract
Structural complexity in the Sunda-Banda arc transition is a topic of much debate amongst Earth scientists. We have processed focal mechanism study using moment tensor...
P Supendi, N Rawlinson, AD Nugraha, S Widiyantoro, CI Abdullah, Daryono, BS Prayitno, M Sadly, D Karnawati
Jun 07, 2022
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease.
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher Jh Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Jan 04, 2022
The most frequent missense mutations in familial Parkinson's disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that...
D. melanogaster Gastrodia elata Blume Lrrk2 NRF2 Parkinson's Disease Glia MOUSE neuroscience Animals Benzyl Alcohols Butyrates Disease Models Animal Dopaminergic Neurons Drosophila melanogaster Gastrodia Glucosides Locomotion Mice NF-E2-Related Factor 2 Neuroglia Neuroprotection Neuroprotective Agents Parkinson Disease Plant Extracts Signal Transduction
dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn Lilley, Michael Mülleder, Alexey I Nesvizhskii, Markus Ralser
Jul 08, 2022
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-picking algorithm and generation of optimized...
dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn S Lilley, Michael Mülleder, Alexey I Nesvizhskii, Markus Ralser
Aug 08, 2022
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-picking algorithm and generation of optimized...
Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
Madu N Soares, Moritz Eggelbusch, Elie Naddaf, Karin HL Gerrits, Marike Schaaf, Bram Borst, W Joost Wiersinga, Michele Vugt, Peter JM Weijs, Andrew J Murray, Rob CI Wüst
Jan 10, 2022
Abstract: Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are...
Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses.
Hwee-Ing Ng, Zewen K Tuong, Germain JP Fernando, Alexandra CI Depelsenaire, Stefano C Meliga, Ian H Frazer, Mark AF Kendall
Nov 26, 2019
Chemical adjuvants are typically used to improve immune responses induced by immunisation with protein antigens. Here we demonstrate an approach to enhance immune responses that does not require chemical adjuvants. We applied...
Antibody response to SARS-CoV-2 infection in humans
Nathan Post, Danielle Eddy, Catherine Huntley, May CI van Schalkwyk, Madhumita Shrotri, David Leeman, Samuel Rigby, Sarah V Williams, William H Bermingham, Paul Kellam, John Maher, Adrian M Shields, Gayatri Amirthalingam, Sharon J Peacock, Sharif A Ismail
Feb 22, 2021
BACKGROUND: Progress in characterising the humoral immune response to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist. Assessment of the full range of evidence generated to date...
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