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Greenwood-Asher Firm Chosen to Help With Presidential Search
Winthrop University
Jan 01, 0001
Committee Chair Kathy Bigham of Rock Hill, S.C., said the committee received contacts from more than a dozen firms, and working within the state's procurement policies, chose Greenwood-Asher of Washington, D.C., and Miramar...
Published by: Winthrop University
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Apr 14, 2021
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to...
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest
Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Mar 02, 2021
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to...
Effective therapeutic strategies in a preclinical mouse model of Charcot-Marie-Tooth disease.
Cristina Nuevo-Tapioles, Fulvio Santacatterina, Brenda Sánchez-Garrido, Cristina Núñez de Arenas, Adrián Robledo-Bérgamo, Paula Martínez-Valero, Lara Cantarero, Beatriz Pardo, Janet Hoenicka, Michael P Murphy, Jorgina Satrústegui, Francesc Palau, José M Cuezva
Aug 02, 2021
Charcot-Marie-Tooth (CMT) disease is a neuropathy that lacks effective therapy. CMT patients show degeneration of peripheral nerves, leading to muscle weakness and loss of proprioception. Loss of mitochondrial oxidative...
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg
Oct 27, 2022
Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression...
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg
Nov 27, 2022
Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression...
Small Business Center Regional Director Named to Michelin Development Committee
Winthrop University
Jan 01, 0001
Michelin North America announced it has set aside $1 million for low-interest loans for small businesses. Companies must be based in Abbeville, Anderson, Cherokee, Greenville, Greenwood, Laurens, Oconee, Pickens, Spartanburg and...
Published by: Winthrop University
Modelling Charcot-Marie-Tooth disease in a dish reveals common cell type-specific alterations.
This scientific commentary refers to ‘Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction’, by Van Lent et al. (doi:10.1093/brain/awab226).
Derjaguin and the DMT Theory
Abstract There is a widespread belief that in the 1970s, two conflicting theories of the adhesion of a spherical particle to a substrate were published: the JKR and DMT theories. And that the...
JA Greenwood
May 24, 2022
CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.
Litao Sun, Na Wei, Bernhard Kuhle, David Blocquel, Scott Novick, Zaneta Matuszek, Huihao Zhou, Weiwei He, Jingjing Zhang, Thomas Weber, Rita Horvath, Philippe Latour, Tao Pan, Paul Schimmel, Patrick R Griffin, Xiang-Lei Yang
May 24, 2021
Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An example is CMT subtype 2N (CMT2N), caused by individual mutations spread out in AlaRS...
AlaRS Charcot-Marie-Tooth disease Neuropilin 1 Alanine-tRNA Ligase Aminoacylation Cells Cultured Charcot-Marie-Tooth disease Crystallography X-Ray Deuterium Exchange Measurement Humans Lymphocytes Mutation Neuropilin-1 Primary Cell Culture Protein Binding Protein Domains Recombinant Proteins SCATTERING Small Angle
The genetic landscape of axonal neuropathies in the middle-aged and elderly
Jan Senderek, Petra Lassuthova, Dagmara Kabzińska, Lisa Abreu, Jonathan Baets, Christian Beetz, Geir J Braathen, David Brenner, Joline Dalton, Lois Dankwa, Tine Deconinck, Peter De Jonghe, Bianca Dräger, Katja Eggermann, Melina Ellis, Carina Fischer, Tanya Stojkovic, David N Herrmann, Rita Horvath, Helle Høyer, Stephan Iglseder, Marina Kennerson, Katharina Kinslechner, Jennefer N Kohler, Ingo Kurth, Nigel G Laing, Phillipa J Lamont, Löscher Wolfgang N, Albert Ludolph, Wilson Marques, Garth Nicholson, Royston Ong, Susanne Petri, Gianina Ravenscroft, Adriana Rebelo, Giulia Ricci, Sabine Rudnik-Schöneborn, Anja Schirmacher, Beate Schlotter-Weigel, Ludger Schoels, Rebecca Schüle, Matthis Synofzik, Bruno Francou, Tim M Strom, Johannes Wagner, David Walk, Julia Wanschitz, Daniela Weinmann, Jochen Weishaupt, Manuela Wiessner, Reinhard Windhager, Peter Young, Stephan Züchner, Stefan Toegel, Pavel Seeman, Andrzej Kochański, Michaela Auer-Grumbach
Nov 19, 2020
OBJECTIVE: To test the hypothesis that monogenic neuropathies such as Charcot-Marie-Tooth disease (CMT) contribute to frequent but often unexplained neuropathies in the elderly, we performed genetic analysis of 230 patients with...
New Editors Publish Winthrop Paper Jan. 31, 1947
Winthrop News Service
Jan 01, 0001
The first issue of The Johnsonian of 1947 will appear February 7th under new editors. Marian Baker of Pageland, SC, and Jean Jones of Greenwood, SC have been elected editor and managing editor, respectively. Miss Baker is a...
Published by: Winthrop University
Design Students Match Up Against Peers in State Competition
Winthrop University
Jan 01, 0001
Faculty member Jesse Weser submitted to a professional design organization show class projects by student Ashley Cook of Greenwood, South Carolina, Savannah Ray of Rock Hill and Wesley Fry of Greenville, South Carolina. The...
Published by: Winthrop University
Natural history of Charcot-Marie-Tooth disease type 2A
Menelaos Pipis, Shawna ME Feely, James M Polke, Mariola Skorupinska, Laura Perez, Rosemary R Shy, Matilde Laura, Jasper M Morrow, Isabella Moroni, Chiara Pisciotta, Franco Taroni, Dragan Vujovic, Thomas E Lloyd, Gyula Acsadi, Sabrina W Yum, Richard A Lewis, Richard S Finkel, David N Herrmann, John W Day, Jun Li, Mario Saporta, Reza Sadjadi, David Walk, Joshua Burns, Francesco Muntoni, Sindhu Ramchandren, Rita Horvath, Nicholas E Johnson, Stephan Züchner, Davide Pareyson, Steven S Scherer, Alexander M Rossor, Michael E Shy, Mary M Reilly, Inherited Neuropathies Consortium - Rare Disease Clinical Research Network (INC-RDCRN)
Oct 15, 2020
Mitofusin-2 (MFN2) is one of two ubiquitously expressed homologous proteins in eukaryote cells, playing a critical role in mitochondrial fusion. Mutations in MFN2 (most commonly autosomal dominant) cause Charcot-Marie-Tooth...
Charcot-Marie-Tooth Examination Score v2.0 Charcot-Marie-Tooth disease type 2A genotype-phenotype correlations mitofusin-2 standardized response mean Adolescent Adult Age of Onset Charcot-Marie-Tooth disease Child Child Preschool Cohort Studies Disease Progression Female GTP Phosphohydrolases Genes Dominant Genes Recessive Genetic Association Studies Genetic Markers Humans Infant Longitudinal Studies Male Mitochondrial Proteins Neurologic Examination Orthotic Devices Prognosis Prospective Studies Wheelchairs Young Adult
Elastohydrodynamic Lubrication
James A. Greenwood
May 08, 2020
The development of EHL theory from its tentative beginnings is outlined, with an account of how Ertel explained its relation to Hertz contact theory. The problems caused by the failure of the early numerical analysts to...
Winthrop Sessions Set for Presidential Finalists as Search Field Narrows
Winthrop University
Jan 01, 0001
The campus visits will be the final phase of a selection process that began last April with the naming of the search committee, which began sorting through applications in October with the assistance of consultant firm...
Published by: Winthrop University
Derjaguin and the DMT Theory
James Greenwood
May 09, 2022
Abstract: There is a widespread belief that in the 1970s, two conflicting theories of the adhesion of a spherical particle to a substrate were published: the JKR and DMT theories. And that the dispute was resolved when Tabor...
A spatial model of the plant circadian clock reveals design principles for coordinated timing.
Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day-night cycle. Mathematical models of the clock are typically either "whole-plant" that ignore tissue or cell...
Student Life Awards Highlight Active Year for Winthrop Student Body
Winthrop University
Jan 01, 0001
Alyssa Toshimitsu, a social work major from Santa Clarita, California, received the Mary Mildred Sullivan Award, while Ian Deas, a biology major from Charleston, South Carolina, won the Algernon Sydney Sullivan Award. The...
Published by: Winthrop University
A multicenter retrospective study of charcot-marie-tooth disease type 4B (CMT4B) associated with mutations in myotubularin-related proteins (MTMRs).
Davide Pareyson, Tanya Stojkovic, Mary M Reilly, Sarah Leonard-Louis, Matilde Laurà, Julian Blake, Yesim Parman, Esra Battaloglu, Meriem Tazir, Mounia Bellatache, Nathalie Bonello-Palot, Nicolas Lévy, Sabrina Sacconi, Raquel Guimarães-Costa, Sharham Attarian, Philippe Latour, Guilhem Solé, André Megarbane, Rita Horvath, Giulia Ricci, Byung-Ok Choi, Angelo Schenone, Chiara Gemelli, Alessandro Geroldi, Mario Sabatelli, Marco Luigetti, Lucio Santoro, Fiore Manganelli, Aldo Quattrone, Paola Valentino, Tatsufumi Murakami, Steven S Scherer, Lois Dankwa, Michael E Shy, Chelsea J Bacon, David N Herrmann, Alberto Zambon, Irene Tramacere, Chiara Pisciotta, Stefania Magri, Stefano C Previtali, Alessandra Bolino
May 28, 2019
OBJECTIVE: Charcot-Marie-Tooth (CMT) disease 4B1 and 4B2 (CMT4B1/B2) are characterized by recessive inheritance, early onset, severe course, slowed nerve conduction, and myelin outfoldings. CMT4B3 shows a more heterogeneous...
The role of tRNA synthetases in neurological and neuromuscular disorders.
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNAs with their cognate amino acids, therefore essential for the first step in protein synthesis. Although the majority of protein...
Functional proteomic atlas of HIV infection in primary human CD4+ T cells.
Adi Naamati, James C Williamson, Edward JD Greenwood, Sara Marelli, Paul J Lehner, Nicholas J Matheson
Mar 28, 2019
Viruses manipulate host cells to enhance their replication, and the identification of cellular factors targeted by viruses has led to key insights into both viral pathogenesis and cell biology. In this study, we develop an HIV...
HIV human immunology infectious disease Inflammation magnetic cell selection microbiology primary human CD4+ T cell Proteomics Virus CD4-Positive T-Lymphocytes Cell Separation Cluster Analysis DNA-Binding Proteins Fragile X Mental Retardation Protein Gene Expression Regulation Green Fluorescent Proteins HIV Infections HIV-1 Humans Hydrogen-Ion Concentration Lentivirus Lymphocyte Activation Magnetics Methyltransferases Protein Binding Protein Tyrosine Phosphatase Non-Receptor Type 22 Proteome Proteomics Streptavidin Virus Replication vif Gene Products Human Immunodeficiency Virus
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