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Structural and Functional Studies of the Unconventional Proteobacterial Transcription Activator CRL in Complex with the Transcription Machinery
Alexis Jaramillo Cartagena
Jan 01, 0001
The ?S subunit of RNA polymerase (RNAP) is the master regulator of stress responses in many Gram-negative bacteria. This alternative ? factor assembles with the core RNA polymerase to initiate the transcription of genes needed...
Published by: Rockefeller University
Gestational length assignment based on last menstrual period, first trimester crown-rump length, ovulation, and implantation timing.
Amita A Mahendru, Charlotte S Wilhelm-Benartzi, Ian B Wilkinson, Carmel M McEniery, Sarah Johnson, Christoph Lees
Nov 22, 2017
PURPOSE: Understanding the natural length of human pregnancy is central to clinical care. However, variability in the reference methods to assign gestational age (GA) confound our understanding of pregnancy length. Assignation...
The Effects of Cognitive Apprenticeship and Co-Regulated Learning on Improving Student Computer Problem-Solving Skills and Learning Motivation: A Quasi-Experiment in an “Applied Information Technology
This study makes use of online teaching in this environment and adopts it for use in a required computer skills course with Cognitive apprenticeship (CA) and Co-regulated learning (CRL) teaching methods to improve students’...
Published by: IGI Global Scientific Publishing
The Effects of Facebook Live-Stream Teaching on Improving Students' Dance Skills
The purpose of this study is to enhance the effect of dance skill learning, learning motivation, and physical activity class satisfaction. Moreover, the outcome of these quasi-experiments illustrate the effects of Facebook...
Published by: IGI Global Scientific Publishing
Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults
Mariagnese Barbera, Francesca Mangialasche, Susan Jongstra, Juliette Guillemont, Tiia Ngandu, Cathrien Beishuizen, Nicola Coley, Carol Brayne, Sandrine Andrieu, Edo Richard, Hilkka Soininen, Miia Kivipelto, HATICE study group
Aug 30, 2018
Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors.
Omid Fotouhi, Hanna Kjellin, C Christofer Juhlin, Yanbo Pan, Mattias Vesterlund, Mehran Ghaderi, Abdelhamid Yousef, Hillevi Andersson-Sand, Pedram Kharaziha, Stefano Caramuta, Magnus Kjellman, Jan Zedenius, Catharina Larsson, Lukas M Orre
Aug 11, 2020
Patients with small intestinal neuroendocrine tumors (SI-NETs) frequently develop spread disease; however, the underlying molecular mechanisms of disease progression are not known and effective preventive treatment strategies...
Rare non-Hodgkin lymphoma of childhood and adolescence
Andishe Attarbaschi, Oussama Abla, Laura Arias Padilla, Auke Beishuizen, GA Amos Burke, Laurence Brugières, Julie Bruneau, Birgit Burkhardt, Emanuele SG d'Amore, Wolfram Klapper, Udo Kontny, Marta Pillon, Mary Taj, Suzanne D Turner, Anne Uyttebroeck, Wilhelm Woessmann, Karin Mellgren
May 04, 2020
Pediatric-type follicular (PTFL), marginal zone (MZL), and peripheral T-cell lymphoma (PTCL) account each for <2% of childhood non-Hodgkin lymphoma. We present clinical and histopathological features of PTFL, MZL, and few...
Pooling individual participant data from randomized controlled trials
Lennard L van Wanrooij, Marieke P Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien RL Beishuizen, Eric P Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 22, 2020
BACKGROUND: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
Pooling individual participant data from randomized controlled trials
Lennard L. van Wanrooij, Marieke P. Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien R. L. Beishuizen, Eric P. Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 12, 2020
Background: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
Interactions between RAMP2 and CRF receptors
Sian Bailey, Matthew Harris, Kerry Barkan, Ian Winfield, Matthew Thomas Harper, John Simms, Graham Ladds, Mark Wheatley, David Poyner
Mar 04, 2019
Corticotrophin releasing factor (CRF) acts via two family B G-protein-coupled receptors, CRFR1 and CRFR2. Additional subtypes exist due to alternative splicing. CRFR1α is the most widely expressed subtype and lacks a 29-residue...
Corticotrophin releasing factor receptor (CRFR) Family B GPCR Receptor activity modifying protein (RAMP) splice variants Translocation Alternative Splicing Animals COS Cells Chlorocebus aethiops HEK293 Cells Humans Models Molecular Receptor Activity-Modifying Protein 2 Receptors Corticotropin-Releasing Hormone
Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma
Lara Mussolin, Marié-Cecilé Le Deley, Elisa Carraro, Christine Damm-Welk, Andishe Attarbaschi, Denise Williams, Amos Burke, Keizo Horibe, Atsuko Nakazawa, Grazyna Wrobel, Georg Mann, Monika Csóka, Anne Uyttebroeck, Rafael Fernández-Delgado Fernández-Delgado Cerdá, Auke Beishuizen, Karin Mellgren, Birgit Burkhardt, Wolfram Klapper, Suzanne D Turner, Emanuele SG d'Amore, Laurence Lamant, Alfred Reiter, Wilhelm Woessmann, Laurence Brugières, Marta Pillon On Behalf Of The European Inter-Group For Childhood Non-Hodgkin Lymphoma Pillon
Sep 22, 2020
With the aim of describing the long-term follow-up and to define the prognostic role of the clinical/pathological/molecular characteristics at diagnosis for childhood, adolescent and young adults affected by anaplastic large...
Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma
Lara Mussolin, Marié-Cecilé Le Deley, Elisa Carraro, Christine Damm-Welk, Andishe Attarbaschi, Denise Williams, Amos Burke, Keizo Horibe, Atsuko Nakazawa, Grazyna Wrobel, Georg Mann, Monika Csóka, Anne Uyttebroeck, Rafael Fernández-Delgado Cerdá, Auke Beishuizen, Karin Mellgren, Birgit Burkhardt, Wolfram Klapper, Suzanne D. Turner, Emanuele S.G. D’Amore, Laurence Lamant, Alfred Reiter, Wilhelm Woessmann, Laurence Brugières, Marta Pillon
Sep 25, 2020
With the aim of describing the long-term follow-up and to define the prognostic role of the clinical/pathological/molecular characteristics at diagnosis for childhood, adolescent and young adults affected by anaplastic large...
Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations.
Birgit Burkhardt, Mary Taj, Nathalie Garnier, Veronique Minard-Colin, Volkan Hazar, Karin Mellgren, Tomoo Osumi, Alina Fedorova, Natalia Myakova, Jaime Verdu-Amoros, Mara Andres, Edita Kabickova, Andishe Attarbaschi, Alan Kwok Shing Chiang, Eva Bubanska, Svetlana Donska, Lisa Lyngsie Hjalgrim, Jacek Wachowiak, Anna Pieczonka, Anne Uyttebroeck, Jelena Lazic, Jan Loeffen, Jochen Buechner, Felix Niggli, Monika Csoka, Gergely Krivan, Julia Palma, GA Amos Burke, Auke Beishuizen, Kristin Koeppen, Stephanie Mueller, Heidi Herbrueggen, Wilhelm Woessmann, Martin Zimmermann, Adriana Balduzzi, Marta Pillon
Apr 26, 2021
Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r...
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E Schwab, Zainab Shahid, Michinori Shirano, Julia E Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Nov 16, 2022
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre...
Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk
Peter Willeit, Lena Tschiderer, Elias Allara, Kathrin Reuber, Lisa Seekircher, Lu Gao, Ximing Liao, Eva Lonn, Hertzel C Gerstein, Salim Yusuf, Frank P Brouwers, Folkert W Asselbergs, Wiek van Gilst, Sigmund A Anderssen, Diederick E Grobbee, John JP Kastelein, Frank LJ Visseren, George Ntaios, Apostolos I Hatzitolios, Christos Savopoulos, Pythia T Nieuwkerk, Erik Stroes, Matthew Walters, Peter Higgins, Jesse Dawson, Paolo Gresele, Giuseppe Guglielmini, Rino Migliacci, Marat Ezhov, Maya Safarova, Tatyana Balakhonova, Eiichi Sato, Mayuko Amaha, Tsukasa Nakamura, Kostas Kapellas, Lisa M Jamieson, Michael Skilton, James A Blumenthal, Alan Hinderliter, Andrew Sherwood, Patrick J Smith, Michiel A van Agtmael, Peter Reiss, Marit GA van Vonderen, Stefan Kiechl, Gerhard Klingenschmid, Matthias Sitzer, Coen DA Stehouwer, Heiko Uthoff, Zhi-Yong Zou, Ana R Cunha, Mario F Neves, Miles D Witham, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Enrique Bernal, Kristian Wachtell, Sverre E Kjeldsen, Michael H Olsen, David Preiss, Naveed Sattar, Edith Beishuizen, Menno V Huisman, Mark A Espeland, Caroline Schmidt, Stefan Agewall, Ercan Ok, Gülay Aşçi, Eric de Groot, Muriel PC Grooteman, Peter J Blankestijn, Michiel L Bots, Michael J Sweeting, Simon G Thompson, Matthias W Lorenz, PROG-IMT and the Proof-ATHERO Study Groups
Sep 08, 2020
BACKGROUND: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. METHODS: We systematically collated data from...