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Brennan Family Establishes Endowed Scholarship for Student-Athletes

Winthrop University

Jan 01, 0001

The Brennan Family Scholarship will support student-athletes at Winthrop. Kieran Brennan's son, Tomas '12, '15, was a four-year soccer player.

Published by: Winthrop University

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Need for ethical framework to guide mass testing for asymptomatic covid-19.

Caitriona Cox, Mary Dixon-Woods

Feb 24, 2021

Asymptomatic Infections covid-19 COVID-19 Testing Humans Mass Screening Pandemics

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Impact of Gastrointestinal Disease States on Oral Drug Absorption – implications for formulation design – a PEARRL review

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Apr 01, 2019

Objectives: Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with...

formulation Gastrointestinal Diseases gastrointestinal physiology in vitro and PBPK models oral drug absorption /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

For poorly soluble compounds, drug product performance in patients with Ulcerative Colitis (UC) compared to healthy subjects can be affected due to differences in drug solubility in GI fluids. A risk assessment tool was...

Biorelevant media Gastrointestinal Diseases inflammatory bowel disease Physicochemical properties Solubility Ulcerative colitis /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

In order to investigate differences in drug solubilisation and dissolution in luminal fluids of Crohn's disease (CD) patients and healthy subjects, biorelevant media representative of CD patients were developed using...

Biorelevant media Crohn's Disease Gastrointestinal Diseases inflammatory bowel disease Physicochemical properties Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Cover Image for Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling

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Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Feb 01, 2021

Objectives: Drug product performance might be affected in Crohn's disease (CD) patients compared to healthy subjects due to pathophysiological changes. Since a low number of clinical studies is performed in this patient...

Absorption bioavailability inflammatory bowel disease Pharmacokinetic modeling Physiologically based pharmacokinetics /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

The aim of this study was to develop an in vitro tool for predicting drug solubility and dissolution in intestinal fluids of patients with Celiac disease (CED). Biorelevant media for patients with CED were developed based on...

Biorelevant media Celiac disease Gastrointestinal Diseases Physicochemical properties Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Heaney, Joyce

Hunter Dukes

May 04, 2018

During an interview with Dennis O'Driscoll published in the 2008 volume Stepping Stones, Seamus Heaney recalls a two-line poem from his childhood: 'Two sticks standing and one across / Spells Willie Brennan in Hillhead Moss'....

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Cover Image for Effectiveness of CoQ10 in Attenuating Parkinsonian Symptoms Caused by Overexpression of the LRRK2 Gene Modeled in Caenorhabditis elegans

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Effectiveness of CoQ10 in Attenuating Parkinsonian Symptoms Caused by Overexpression of the LRRK2 Gene Modeled in Caenorhabditis elegans

Brennan W. McFarland

Jan 01, 0001

Reactive oxygen species (ROS) are reactive molecules that contain oxygen. ROS are naturally formed as a byproduct of cellular processes that metabolize oxygen. These products continue to react with and damage DNA, proteins, and...

CoQ10 Parkinson's Disease Lrrk2 Caenorhabditis elegans neurodegeneration Oxidative Stress Biology Genetics and Genomics Life Sciences Molecular genetics

Published by: Ursinus College

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

Biorelevant media Gastrointestinal Diseases inflammatory bowel disease Physicochemical properties Solubility Ulcerative colitis /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Impact of Gastrointestinal Disease States on Oral Drug Absorption – implications for formulation design – a PEARRL review

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Apr 01, 2019

Published by:

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

Biorelevant media Celiac disease Gastrointestinal Diseases Physicochemical properties Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Gastrointestinal diseases and their impact on drug solubility

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Sep 01, 2020

Biorelevant media Crohn's Disease Gastrointestinal Diseases inflammatory bowel disease Physicochemical properties Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling

Angela Effinger, Caitriona M. O'Driscoll, Mark McAllister, Nikoletta Fotaki

Feb 01, 2021

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Taxonomic signatures of cause-specific mortality risk in human gut microbiome.

Aaro Salosensaari, Ville Laitinen, Aki S Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D Watrous, Tao Long, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu Niiranen

Jun 12, 2021

The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally...

Adolescent Adult Aged Cause of Death Cohort Studies Cross-Sectional Studies Enterobacteriaceae Feces Female Finland Gastrointestinal Microbiome Humans Male Middle Aged Population Surveillance RNA Ribosomal 16S Risk Factors Young Adult

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Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Aaro Salosensaari, Ville Laitinen, Aki S. Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D. Watrous, Tao Long, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu Niiranen

May 11, 2021

article /631/326/107 /631/326/2565/2142 /692/53/2422 /45/23 article

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Cover Image for Age at Weaning and Infant Growth

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Cover Image for Comparing repeated self-reflective methods on entrustable professional activities (EPAS) performance for post-graduate medical learners

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Comparing repeated self-reflective methods on entrustable professional activities (EPAS) performance for post-graduate medical learners

Timothy Brennan, Kathryn Sparrow, Kristen Romme, Michael Bautista

Jul 19, 2019

Published by: Medical Education and Scholarship Centre, Memorial University

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Parallel mechanisms for visual search in zebrafish

Michael J Proulx, Matthew O Parker, Yasser Tahir, Caroline H Brennan

Jan 01, 0001

Parallel visual search mechanisms have been reported previously only in mammals and birds, and not animals lacking an expanded telencephalon such as bees. Here we report the first evidence for parallel visual search in fish...

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Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma

Laurence Johann Glancz, Michael Tin Chung Poon, Peter John Hutchinson, Angelos Georgiou Kolias, Paul Martin Brennan

Jun 06, 2020

Original Article - Brain Trauma brain trauma Burr hole evacuation chronic subdural haematoma Drains Midline shift outcomes Radiology

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Mechanisms of Action in a Behavioral Weight-Management Program

Sarah Bates, Paul Norman, Penny Breeze, Alan Brennan, Amy L Ahern

Apr 26, 2021

BACKGROUND: A greater understanding of the mechanisms of action of weight-management interventions is needed to inform the design of effective interventions. PURPOSE: To investigate whether dietary restraint, habit strength, or...