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Heat shock factor 1 is a substrate for p38 mitogen-activated Protein Kinases

Heat Shock Factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We...

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Heat shock factor 1 is a substrate for p38 mitogen-activated Protein Kinases

Heat Shock Factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We...

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Evidence complacency hampers conservation.
The pernicious problem of evidence complacency, illustrated here through conservation policy and practice, results in poor practice and inefficiencies. It also increases our vulnerability to a ‘post-truth’ world dealing with...
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Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome
D.C. is funded by a Diabetes Research & Wellness Foundation Sutherland-Earl Clinical Fellowship (RG68554). R.W.H. is supported by the Wellcome Trust–University of Edinburgh Institutional Strategic Support Fund. N.D. is supported...
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Modelling fat mass as a function of weekly physical activity profiles measured by Actigraph accelerometers
We show results on the Avon longitudinal study of parents and children (ALSPAC) using a new approach for modelling the relationship between health outcomes and physical activity assessed by accelerometers. The key feature of the...
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A fresh approach to evidence synthesis.
For most conservation interventions, insufficient evidence exists for investigators to be able to conduct a meta-analysis for each species or genus. However, by being apprised of studies that examine how a particular...
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The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology.
Dementia affects millions of individuals worldwide, yet there are no effective treatments. Alzheimer's disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to...
A Birth Cohort Analysis to Study Dog Walking in Adolescence Shows No Relationship with Objectively Measured Physical Activity.
Physical inactivity during childhood and adolescence is a serious health concern. There are few studies of the activity undertaken by adolescents when walking with the family dog, and the effect of this on objectively measured...
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