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Results: 37
The Nanomechanics of Protocadherin 15, A Protein Essential for Human Hearing
Camila M Villasante
Jan 01, 0001
Mechanical force controls the opening and closing of mechanotransductive ion channels atop the hair bundles in the inner ear.A mechanical element called the gating spring modulates the mechanotransduction channel's open...
Published by: Rockefeller University
Continuous dynamic adjustment of the plant circadian oscillator.
The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana. The circadian oscillator is an important regulator of much of plant physiology, though many of the mechanisms are...
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Genetic analysis of wheat sensitivity to the ToxB fungal effector from Pyrenophora tritici-repentis, the causal agent of tan spot
Abstract: Key message: Genetic mapping of sensitivity to the Pyrenophora tritici-repentis effector ToxB allowed development of a diagnostic genetic marker, and investigation of wheat pedigrees allowed transmission of sensitive...
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Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism.
Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain growth at night. Two competing hypotheses have been proposed to explain this diel starch turnover based on either the measurement of starch...
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Neuroserpin Inclusion Bodies in a FENIB Yeast Model.
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which...
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The Earth BioGenome Project 2020
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Complete vertebrate mitogenomes reveal widespread repeats and gene duplications
Abstract: Background: Modern sequencing technologies should make the assembly of the relatively small mitochondrial genomes an easy undertaking. However, few tools exist that address mitochondrial assembly directly. Results: As...
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Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of...
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