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Results: 33
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael J Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steven Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jul 20, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steve Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jun 17, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
It All Connects
The COVID-19 pandemic forced society to reevaluate the role of technology in the blink of an eye, and virtual learning environments became a necessity rather than an option. Even those instructors who were accustomed to remote...
Educational Technologies Education Educational Technologies Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
Carine Waase-Maurer
Jan 01, 0001
Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering...
Published by: Rockefeller University
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos.
L Carine Stapel, Benoit Lombardot, Coleman Broaddus, Dagmar Kainmueller, Florian Jug, Eugene W Myers, Nadine L Vastenhouw
Jun 28, 2019
Analysis of differential gene expression is crucial for the study of cell fate and behavior during embryonic development. However, automated methods for the sensitive detection and quantification of RNAs at cellular resolution...
Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs.
Stephanie Oerum, Tom Dendooven, Marjorie Catala, Laetitia Gilet, Clément Dégut, Aude Trinquier, Maxime Bourguet, Pierre Barraud, Sarah Cianferani, Ben F Luisi, Ciarán Condon, Carine Tisné
Jan 06, 2021
The pathways for ribosomal RNA (rRNA) maturation diverge greatly among the domains of life. In the Gram-positive model bacterium, Bacillus subtilis, the final maturation steps of the two large ribosomal subunit (50S) rRNAs, 23S...
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
Isabela Cunha Navarro, Francesca Tuorto, David Jordan, Carine Legrand, Jonathan Price, Fabian Braukmann, Alan G Hendrick, Alper Akay, Annika Kotter, Mark Helm, Frank Lyko, Eric A Miska
Nov 12, 2020
Methylation of carbon-5 of cytosines (m5 C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5 C-methyltransferases have been studied, the impact of the global cytosine-5...
Caenorhabditis elegans 5-Methylcytosine NSUN RNA modifications translation efficiency 5-Methylcytosine Adaptation Physiological Animals CRISPR-Cas Systems Caenorhabditis elegans Cytosine Gene Editing Heat-Shock Response Hot Temperature Leucine Methyltransferases Mitochondria Proline Protein Biosynthesis RNA RNA processing Post-Transcriptional Ribosomes
Global and stage specific patterns of Krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells.
Andrea Corsinotti, Adamandia Kapopoulou, Carine Gubelmann, Michael Imbeault, Francesca R Santoni de Sio, Helen M Rowe, Yoann Mouscaz, Bart Deplancke, Didier Trono
Dec 12, 2019
Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and the earliest steps of mammalian development. KRAB-containing zinc finger proteins represent the largest group of transcription...
Parents' experiences of using remote monitoring technology to manage type 1 diabetes in very young children during a clinical trial
Ruth I Hart, Barbara Kimbell, David Rankin, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Carine de Beaufort, Elke Fröhlich-Reiterer, Julia Ware, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Ajay Thankamony, Roman Hovorka, Julia Lawton, KidsAP Consortium
Mar 31, 2022
Closed-loop system Parents qualitative research remote monitoring sensor-augmented pump therapy type 1 diabetes young children Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Clinical Trials as Topic Diabetes mellitus Type 1 Humans Infant Insulin Insulin Infusion Systems Parents Remote Sensing Technology
The cellular composition of the human immune system is shaped by age and cohabitation.
Edward J Carr, James Dooley, Josselyn E Garcia-Perez, Vasiliki Lagou, James C Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A Linterman, Adrian Liston
Jun 25, 2019
Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high...
MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.
Tania Capeloa, Joanna Krzystyniak, Donatienne d'Hose, Amanda Canas Rodriguez, Valery L Payen, Luca X Zampieri, Justine A Van de Velde, Zohra Benyahia, Erica Pranzini, Thibaut Vazeille, Maude Fransolet, Caroline Bouzin, Davide Brusa, Carine Michiels, Bernard Gallez, Michael P Murphy, Paolo E Porporato, Pierre Sonveaux
Apr 24, 2022
To successfully generate distant metastases, metastatic progenitor cells must simultaneously possess mesenchymal characteristics, resist to anoïkis, migrate and invade directionally, resist to redox and shear stresses in the...
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.
Wanze Chen, Petra C Schwalie, Eugenia V Pankevich, Carine Gubelmann, Sunil K Raghav, Riccardo Dainese, Marco Cassano, Michael Imbeault, Suk Min Jang, Julie Russeil, Tenagne Delessa, Julien Duc, Didier Trono, Christian Wolfrum, Bart Deplancke
Dec 12, 2019
Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable...
3T3 Cells Adipocytes Adipogenesis Animals Computational Biology DNA-Binding Proteins Enhancer Elements Genetic Female Gene Expression Regulation Gene Knockout Techniques HEK293 Cells Humans Male Mice Mice Inbred C57BL Mice Transgenic PPAR gamma Promoter Regions Genetic Retroelements Transcription Factors Tripartite Motif-Containing Protein 28 Zinc Fingers
Establishing a Unified COVID-19 "Immunome"
Els Wauters, Karin Thevissen, Carine Wouters, Francesca Maria Bosisio, Frederik De Smet, Jan Gunst, Stephanie Humblet-Baron, Diether Lambrechts, Adrian Liston, Patrick Matthys, Johan Neyts, Paul Proost, Birgit Weynand, Joost Wauters, Sabine Tejpar, Abhishek D Garg
Sep 09, 2020
Abnormal differentiation of B cells and megakaryocytes in patients with Roifman syndrome.
Jessica Heremans, Josselyn E Garcia-Perez, Ernest Turro, Susan M Schlenner, Ingele Casteels, Roxanne Collin, Francis de Zegher, Daniel Greene, Stephanie Humblet-Baron, Sylvie Lesage, Patrick Matthys, Christopher J Penkett, Karen Put, Kathleen Stirrups, National Institute for Health Research BioResource, Chantal Thys, Chris van Geet, Erika Van Nieuwenhove, Carine Wouters, Isabelle Meyts, Kathleen Freson, Adrian Liston
Jun 04, 2018
BACKGROUND: Roifman syndrome is a rare inherited disorder characterized by spondyloepiphyseal dysplasia, growth retardation, cognitive delay, hypogammaglobulinemia, and, in some patients, thrombocytopenia. Compound heterozygous...
B cells RNA processing Roifman syndrome platelets Adolescent B-Lymphocytes Blood Platelets Cardiomyopathies Cell Differentiation Cell Lineage Cell Proliferation Cells Cultured Child Child Preschool Humans Immunologic Deficiency Syndromes Infant Megakaryocytes Mental Retardation X-Linked Mitogen-Activated Protein Kinase 1 Osteochondrodysplasias Pedigree Precursor Cells B-Lymphoid Primary Immunodeficiency Diseases Protein Splicing RNA Small Nuclear Retinal Diseases Signal Transduction Exome Sequencing
MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.
Tania Capeloa, Joanna Krzystyniak, Donatienne d'Hose, Amanda Canas Rodriguez, Valery L Payen, Luca X Zampieri, Justine A Van de Velde, Zohra Benyahia, Erica Pranzini, Thibaut Vazeille, Maude Fransolet, Caroline Bouzin, Davide Brusa, Carine Michiels, Bernard Gallez, Mike Murphy, Paolo E Porporato, Pierre Sonveaux
Mar 17, 2022
To successfully generate distant metastases, metastatic progenitor cells must simultaneously possess mesenchymal characteristics, resist to anoïkis, migrate and invade directionally, resist to redox and shear stresses in the...
Functional analysis of Salmonella Typhi adaptation to survival in water.
Robert A Kingsley, Gemma Langridge, Sarah E Smith, Carine Makendi, Maria Fookes, Tom M Wileman, Moataz Abd El Ghany, A Keith Turner, Zoe A Dyson, Sushmita Sridhar, Derek Pickard, Sally Kay, Nicholas Feasey, Vanessa Wong, Lars Barquist, Gordon Dougan
May 09, 2019
Contaminated water is a major risk factor associated with the transmission of Salmonella enterica serovar Typhi (S. Typhi), the aetiological agent of human typhoid. However, little is known about how this pathogen adapts to...
Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study)
Julia Fuchs, Janet M Allen, Charlotte K Boughton, Malgorzata E Wilinska, Ajay Thankamony, Carine de Beaufort, Fiona Campbell, James Yong, Elke Froehlich-Reiterer, Julia K Mader, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Martin Tauschmann, Korey Hood, Barbara Kimbell, Julia Lawton, Stephane Roze, Judy Sibayan, Nathan Cohen, Roman Hovorka, KidsAP Consortium
Jan 12, 2021
INTRODUCTION: Diabetes management in very young children remains challenging. Glycaemic targets are achieved at the expense of high parental diabetes management burden and frequent hypoglycaemia, impacting quality of life for...
DIABETES & ENDOCRINOLOGY general diabetes paediatric endocrinology Paediatrics Austria Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Humans Hypoglycemic Agents Infant Insulin Insulin Infusion Systems Luxembourg Multicenter Studies as Topic Quality of life Randomized Controlled Trials as Topic Treatment Outcome
Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children
Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Barber, Malgorzata E Wilinska, Charlotte Boughton, Gianluca Musolino, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
Jan 29, 2019
Multi-omics profiling of mouse gastrulation at single-cell resolution.
Ricard Argelaguet, Stephen J Clark, Hisham Mohammed, L Carine Stapel, Christel Krueger, Chantriolnt-Andreas Kapourani, Ivan Imaz-Rosshandler, Tim Lohoff, Yunlong Xiang, Courtney W Hanna, Sebastien Smallwood, Ximena Ibarra-Soria, Florian Buettner, Guido Sanguinetti, Wei Xie, Felix Krueger, Berthold Göttgens, Peter J Rugg-Gunn, Gavin Kelsey, Wendy Dean, Jennifer Nichols, Oliver Stegle, John C Marioni, Wolf Reik
Oct 29, 2019
Animals Cell Differentiation Cell Lineage Chromatin DNA Methylation Demethylation Embryoid Bodies Endoderm Enhancer Elements Genetic Epigenesis Genetic epigenome Erythropoiesis Factor Analysis Statistical Gastrula Gastrulation Gene Expression Regulation Developmental Mesoderm Mice Pluripotent Stem Cells RNA Single-Cell Analysis Time Factors Zinc Fingers
Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment
Carine de Beaufort, Ineke M. Pit-ten Cate, Ulrike Schierloh, Nathan Cohen, Charlotte K. Boughton, Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Alena G. Thiele, Daniela Abt, Kerstin Faninger, Julia K. Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E. Wilinska, Judy Sibayan, Craig Kollman, Sabine E. Hofer, Elke Fröhlich-Reiterer, Thomas M. Kapellen, Carlo L. Acerini, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
Aug 27, 2021
Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental...
Young Children Have Higher Variability of Insulin Requirements
Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Carlo L Acerini, Sabine Arnolds, Carine de Beaufort, Richard M Bergenstal, Fiona Campbell, Amy Criego, David B Dunger, Daniella Elleri, Mark L Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R Pieber, Birgit Rami-Merhar, Viral N Shah, Judy Sibayan, Malgorzata E Wilinska, Roman Hovorka, AP@Home, and KidsAP Consortia APCam11
Apr 30, 2019
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young...
Adolescent Adult Age Factors Aged Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Individuality Infant Insulin Insulin Infusion Systems Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Retrospective Studies Young Adult
Reduced burden of diabetes and improved quality of life
Gianluca Musolino, Klemen Dovc, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G Thiele, Daniela Abt, Harald Kojzar, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka, KidsAP Consortium
May 29, 2019
OBJECTIVE: To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. METHODS: Parents/caregivers of 20 children...
Artificial Pancreas closed-loop insulin delivery type 1 diabetes very young children Blood Glucose Blood Glucose Self-Monitoring Caregivers Child Child Preschool Circadian Rhythm Cost of Illness Cross-Over Studies Diabetes mellitus Type 1 Family Female Humans Infant Insulin Insulin Infusion Systems Male Parents Quality of life Surveys and Questionnaires
Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes - Baseline Assessment.
Carine de Beaufort, Ineke M Pit-Ten Cate, Ulrike Schierloh, Nathan Cohen, Charlotte K Boughton, Martin Tauschmann, Janet M Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Alena G Thiele, Daniela Abt, Kerstin Faninger, Julia K Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E Wilinska, Judy Sibayan, Craig Kollman, Sabine E Hofer, Elke Fröhlich-Reiterer, Thomas M Kapellen, Carlo L Acerini, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
Jul 27, 2021
BACKGROUND: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental...
Child Behavior hypoglycemia fear parental well-being Sleepiness type 1 diabetes very young children Adult Age of Onset Anxiety Child Child Behavior Child Preschool Diabetes mellitus Type 1 Europe Fear Female Humans Hypoglycemia Infant Insulin Insulin Infusion Systems Male Parents Surveys and Questionnaires
Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study.
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra Hm Peeters, Carla H van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Sep 26, 2018
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to...
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