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Results: 20
Impact of cholesterol on proinflammatory monocyte production by the bone marrow.
Lotte CA Stiekema, Lisa Willemsen, Yannick Kaiser, Koen HM Prange, Nicholas J Wareham, S Matthijs Boekholdt, Carlijn Kuijk, Menno PJ de Winther, Carlijn Voermans, Matthias Nahrendorf, Erik SG Stroes, Jeffrey Kroon
Aug 16, 2021
AIM: Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune response at plaque level but also augments proinflammatory monocyte production in...
Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA
Frank Behrens, Juan D Cañete, Ignazio Olivieri, Arno W van Kuijk, Neil McHugh, Bernard Combe
May 01, 2015
The aim of this study was to review the available evidence on TNF inhibitor monotherapy vs combination therapy with MTX in PsA.
Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA
Frank Behrens, Juan D Cañete, Ignazio Olivieri, Arno W van Kuijk, Neil McHugh, Bernard Combe
May 01, 2015
The aim of this study was to review the available evidence on TNF inhibitor monotherapy vs combination therapy with MTX in PsA.
Sample descriptors linked to metagenomic sequencing data from human and animal enteric samples from Vietnam.
Mark Woolhouse, Jordan Ashworth, Carlijn Bogaardt, Ngo Tri Tue, Steve Baker, Guy Thwaites, Tran My Phuc
May 17, 2021
There is still limited information on the diversity of viruses co-circulating in humans and animals. Here, we report data obtained from a large field collection of enteric samples taken from humans, pigs, rodents and other...
Sample descriptors linked to metagenomic sequencing data from human and animal enteric samples from Vietnam
Mark Woolhouse, Jordan Ashworth, Carlijn Bogaardt, Ngo Tri Tue, Steve Baker, Guy Thwaites, Tran My Phuc
Oct 14, 2020
Abstract: There is still limited information on the diversity of viruses co-circulating in humans and animals. Here, we report data obtained from a large field collection of enteric samples taken from humans, pigs, rodents and...
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
Janne W Bolt, Arno W van Kuijk, Marcel BM Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M Gerlag, Paul P Tak, Marleen G van de Sande, Maria C Lebre, Lisa GM van Baarsen
Jan 30, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether...
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
Mar 28, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
The link between maternal obesity and offspring neurobehavior
Malou D Menting, Cornelieke van de Beek, Stijn Mintjens, Kimberley E Wever, Aniko Korosi, Susan E Ozanne, Jacqueline Limpens, Tessa J Roseboom, Carlijn Hooijmans, Rebecca C Painter
Jan 30, 2019
Maternal obesity in pregnancy is associated with neurobehavioral problems in the offspring. Establishing causality has been challenging in existing human studies, due to confounding by genetic and postnatal environment. Animal...
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
May 13, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.
Johanna P van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian ME Tullemans, Fiorella A Solari, Bing Peng, Kenneth J Clemetson, Richard W Farndale, Ludwig J Dubois, Albert Sickmann, René P Zahedi, Robert Ahrends, Erik AL Biessen, Judith C Sluimer, Johan WM Heemskerk, Marijke JE Kuijpers
Feb 12, 2021
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic...
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Dec 08, 2020
Genetic diversity and cross-species transmission of kobuviruses in Vietnam.
Lu Lu, Nguyen Van Dung, Alasdair Ivens, Carlijn Bogaardt, Aine O'Toole, Juliet E Bryant, Juan Carrique-Mas, Nguyen Van Cuong, Pham Hong Anh, Maia A Rabaa, Ngo Tri Tue, Guy E Thwaites, Stephen Baker, Peter Simmonds, Mark Ej Woolhouse, VIZIONS consortium
May 17, 2021
Cross-species transmission of viruses poses a sustained threat to public health. Due to increased contact between humans and other animal species the possibility exists for cross-species transmissions and ensuing disease...
Knock-in models related to Alzheimer’s disease
Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A. Salih, Takshashila Tripathi, Frances A. Edwards, Damian M. Cummings
Aug 13, 2021
Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE)
Jeanette Tas, Erta Beqiri, Ruud C van Kaam, Marek Czosnyka, Joseph Donnelly, Roel H Haeren, Iwan CC van der Horst, Peter J Hutchinson, Sander MJ van Kuijk, Analisa L Liberti, David K Menon, Cornelia WE Hoedemaekers, Bart Depreitere, Peter Smielewski, Geert Meyfroidt, Ari Ercole, Marcel JH Aries
Jul 05, 2021
Managing traumatic brain injury (TBI) patients with a cerebral perfusion pressure (CPP) near to the cerebral autoregulation (CA)-guided "optimal" CPP (CPPopt) value is associated with improved outcome and might be useful to...
cerebral autoregulation cerebral perfusion Intensive Care Optimal cerebral perfusion pressure Precision Medicine Traumatic brain injury Adult Aged Brain Injuries Traumatic Cerebrovascular Circulation Endpoint Determination Feasibility Studies Female Homeostasis Humans Male Middle Aged Neurophysiological Monitoring Perfusion Retrospective Studies Software Treatment Outcome
Knock-in models related to Alzheimer's disease
Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cummings
Aug 16, 2021
BACKGROUND: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relationships...
Ageing Alzheimer’s disease amyloid beta Gene Expression Microglia neurodegeneration Plaques synaptic plasticity Synaptic Transmission TREM2 Alzheimer Disease Amyloid beta-Protein Precursor Animals Disease Models Animal Gene Knock-In Techniques Humans Mice Microglia Plaque Amyloid Synaptic Transmission
Knock-in models related to Alzheimer’s disease
Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A. Salih, Takshashila Tripathi, Frances A. Edwards, Damian M. Cummings
Jul 28, 2021
Dysfunctional posttraumatic cognitions, posttraumatic stress, and depression in children and adolescents exposed to trauma
Anke de Haan, Markus Landolt, Eiko Fried, Kristian Kleinke, Eva Alisic, Richard Bryant, Karen Salmon, Sue-Huei Chen, Shu-Tsen Liu, Tim Dalgleish, Anna McKinnon, Alice Alberici, Jade Claxton, Julia Diehle, Ramon Lindauer, Carlijn de Roos, Sarah Halligan, Rachel Hiller, Christian Haag Kristensen, Beatriz de Oliveira Meneguelo Lobo, Nicole Michaela Volkmann, Meghan Marsac, Lamia Barakat, Nancy Kassam-Adams, Reginald Nixon, Susan Hogan, Raika-Leena Punamaki, Esa Palosaari, Elizabeth Schilpzand, Rowena Conroy, Patrick Smith, William Yule, Richard Meiser-Stedman
Dec 10, 2019
Background: The latest version of the International Classification of Diseases (ICD-11) proposes a posttraumatic stress disorder (PTSD) diagnosis reduced to its core symptoms within the symptom clusters re-experiencing...
children DSM-5 ICD-11 ADOLESCENTS Depression Network analysis posttraumatic cognitions Posttraumatic stress disorder trauma /dk/atira/pure/subjectarea/asjc/2700/2735 name=Pediatrics, Perinatology, and Child Health /dk/atira/pure/subjectarea/asjc/3200/3204 name=Developmental and Educational Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Dysfunctional posttraumatic cognitions, posttraumatic stress, and depression in children and adolescents exposed to trauma
Anke de Haan, Markus Landolt, Eiko Fried, Kristian Kleinke, Eva Alisic, Richard Bryant, Karen Salmon, Sue-Huei Chen, Shu-Tsen Liu, Tim Dalgleish, Anna McKinnon, Alice Alberici, Jade Claxton, Julia Diehle, Ramon Lindauer, Carlijn de Roos, Sarah Halligan, Rachel Hiller, Christian Haag Kristensen, Beatriz de Oliveira Meneguelo Lobo, Nicole Michaela Volkmann, Meghan Marsac, Lamia Barakat, Nancy Kassam-Adams, Reginald Nixon, Susan Hogan, Raika-Leena Punamaki, Esa Palosaari, Elizabeth Schilpzand, Rowena Conroy, Patrick Smith, William Yule, Richard Meiser-Stedman
Dec 10, 2019
Background: The latest version of the International Classification of Diseases (ICD-11) proposes a posttraumatic stress disorder (PTSD) diagnosis reduced to its core symptoms within the symptom clusters re-experiencing...
children DSM-5 ICD-11 ADOLESCENTS Depression Network analysis posttraumatic cognitions Posttraumatic stress disorder trauma /dk/atira/pure/subjectarea/asjc/2700/2735 name=Pediatrics, Perinatology, and Child Health /dk/atira/pure/subjectarea/asjc/3200/3204 name=Developmental and Educational Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits
Alexandra Hendry, Emily J. H. Jones, Rachael Bedford, Linn Andersson Konke, Jannath Begum Ali, Sven Bӧlte, Karin C. Brocki, Ellen Demurie, Mark Johnson, Mirjam K. J. Pijl, Herbert Roeyers, Tony Charman, Sheila Achermann, Mary Agyapong, Rebecka Astenvald, Lisa Axelson, Tessel Bazelmans, Karlijn Blommers, Chloè Bontinck, Carlijn van den Boomen, Sofie Boterberg, Ricarda Braukmann, Yvette de Bruijn, Eva Bruyneel, Jan K. Buitelaar, Leila Dafner, Fahime Darki, Kim Davies, Mutluhan Ersoy, Terje Falck-Ytter, Janice Fernandes, Zoë Freeman, Teea Gliga, Gustaf Gredebäck, Marian Greensmith, Rianne Haartsen, Sanne van Ierland-Veerhoek, Maretha V. de Jonge, Sarah Kalwarowsky, Chantal Kemner, Anna Kolesnik, Manon de Korte, Johan Lundin-Kleberg, Nicolette M. Munsters, Pär Nyström, Greg Pasco, Laura Pirazzoli, Johanna Ristolainen, Andrietta Stadin, Chloë Taylor, Emilia Thorup, Natalie vaz, Loes Vinkenvleugel, Emma Ward, Petra Warreyn, Lilli N. van Wielink
Oct 15, 2020