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Results: 78784
Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA.
Davina Gale, Andrew RJ Lawson, Karen Howarth, Mikidache Madi, Bradley Durham, Sarah Smalley, John Calaway, Shannon Blais, Greg Jones, James Clark, Peter Dimitrov, Michelle Pugh, Samuel Woodhouse, Michael Epstein, Ana Fernandez-Gonzalez, Alexandra S Whale, Jim F Huggett, Carole A Foy, Gerwyn M Jones, Hadas Raveh-Amit, Karin Schmitt, Alison Devonshire, Emma Green, Tim Forshew, Vincent Plagnol, Nitzan Rosenfeld
Jul 16, 2018
INTRODUCTION: Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing number of gene targets have been identified as diagnostic...
Adult Alleles Biomarkers Tumor Cell-Free Nucleic Acids Circulating Tumor DNA DNA Mutational Analysis DNA Neoplasm Female High-Throughput Nucleotide Sequencing Humans Liquid biopsy Male Mutation Neoplasms Neoplastic Cells Circulating Polymerase Chain Reaction Reproducibility of Results Sensitivity and Specificity
Enabling patients with advanced chronic obstructive pulmonary disease to identify and express their support needs to health care professionals
Chronic obstructive pulmonary disease communication Needs Assessment patient-centred care qualitative evidence-based practice Aged Aged 80 and over Caregivers communication England Female Focus Groups Humans Male Middle Aged Needs Assessment Nurse-Patient Relations Nursing Staff hospital Patient Preference Pulmonary Disease Chronic Obstructive qualitative research
Support Needs Approach for Patients (SNAP) tool
OBJECTIVES:Patient-identified need is key to delivering holistic, supportive, person-centred care, but we lack tools enabling patients to express what they need to manage life with a long-term condition. The Support Needs...
Understanding how the Support Needs Approach for Patients (SNAP) enables identification, expression and discussion of patient support needs
A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL.
Rubben Torella, Jinghua Li, Eddie Kinrade, Gustavo Cerda-Moya, Ashley N Contreras, Robert Foy, Robert Stojnic, Robert C Glen, Rhett A Kovall, Boris Adryan, Sarah J Bray
Aug 22, 2014
Can an ethics officer role reduce delays in research ethics approval? A mixed-method evaluation of an improvement project.
Mary Dixon-Woods, Chris Foy, Charlotte Hayden, Rustam Al-Shahi Salman, Stephen Tebbutt, Sara Schroter
Sep 09, 2016
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Structured follow-up pathway to support people after transient ischaemic attack and minor stroke (SUPPORT TIA)
Grace M Turner, Rachael Jones, Phillip Collis, Smitaa Patel, Sue Jowett, Sarah Tearne, Robbie Foy, Lou Atkins, Jonathan Mant, Melanie Calvert
Jun 29, 2022
INTRODUCTION: People who experience transient ischaemic attack (TIA) and minor stroke have limited follow-up despite rapid specialist review in hospital. This means they often have unmet needs and feel abandoned following...
depression & mood disorders organisation of health services Protocols & guidelines qualitative research rehabilitation medicine STROKE MEDICINE Feasibility Studies Follow-Up Studies Humans Ischemic Attack Transient Multicenter Studies as Topic Quality of life Randomized Controlled Trials as Topic stroke
'I'm fine!': Assertions of lack of support need among patients with chronic obstructive pulmonary disease
A Carole Gardener, Caroline Moore, Morag Farquhar, Gail Ewing, Efthalia Massou, Robbie Duschinsky
Aug 23, 2022
Does Addictive Pleasure at Work and Building a Personal IS on One's Smartphone Lead to Problematic Smartphone Dependency?
Using a sample of 848 workers in France, this article aims to explain problematic smartphone dependency, a behavior considered to have negative consequences for sufferers in the context of work. It examines whether and how...
Published by: IGI Global Scientific Publishing
A flash of polarized optical light points to an aspherical ‘cow’
Justyn R. Maund, Peter A. Hoflich, Iain A. Steele, Yi Yang, Klaas Wiersema, Shiho Kobayashi, Nuria Jordana-Mitjans, Carole Mundell, Andreja Gomboc, Cristiano Guidorzi, Robert J. Smith
May 01, 2023
The astronomical transient AT2018cow is the closest example of the new class of luminous, fast blue optical transients (FBOTs). Liverpool telescope RINGO3 observations of AT 2018cow are reported here, which constitute the...
TIA and minor stroke
Grace M. Turner, Christel McMullan, Lou Atkins, Robbie Foy, Jonathan Mant, Melanie Calvert
Dec 22, 2020
Abstract: Background: Transient ischaemic attack (TIA) and minor stroke are often considered transient events; however, many patients experience residual problems and reduced quality of life. Current follow-up healthcare focuses...
Are within-person Numerical Rating Scale (NRS) ratings of breathlessness 'on average' valid in advanced disease for patients and for patients' informal carers?
Joshua Wade, Silvia Mendonca, Sara Booth, Gail Ewing, A Carole Gardener, Morag Farquhar
Jan 19, 2018
INTRODUCTION: The Numerical Rating Scale (NRS) is frequently used to assess patient-reported breathlessness in both a research and clinical context. A subgroup of patients report average breathlessness as worse than their worst...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Factors influencing follow-up care post-TIA and minor stroke
Grace M Turner, Maria Raisa Jessica V Aquino, Lou Atkins, Robbie Foy, Jonathan Mant, Melanie Calvert
Feb 21, 2022
BACKGROUND: Follow-up care after transient ischaemic attack (TIA) and minor stroke has been found to be sub-optimal, with individuals often feeling abandoned. We aimed to explore factors influencing holistic follow-up care after...
TIA and minor stroke
Grace M Turner, Christel McMullan, Lou Atkins, Robbie Foy, Jonathan Mant, Melanie Calvert
Feb 07, 2020
BACKGROUND: Transient ischaemic attack (TIA) and minor stroke are often considered transient events; however, many patients experience residual problems and reduced quality of life. Current follow-up healthcare focuses on stroke...
A flash of polarized optical light points to an aspherical ‘cow’
Justyn R. Maund, Peter A. Hoflich, Iain A. Steele, Yi Yang, Klaas Wiersema, Shiho Kobayashi, Nuria Jordana-Mitjans, Carole Mundell, Andreja Gomboc, Cristiano Guidorzi, Robert J. Smith
May 01, 2023
The astronomical transient AT2018cow is the closest example of the new class of luminous, fast blue optical transients (FBOTs). Liverpool telescope RINGO3 observations of AT 2018cow are reported here, which constitute the...
TIA and minor stroke
Grace M Turner, Christel McMullan, Lou Atkins, Robbie Foy, Jonathan Mant, Melanie Calvert
Jan 27, 2020
BACKGROUND:Transient ischaemic attack (TIA) and minor stroke are often considered transient events; however, many patients experience residual problems and reduced quality of life. Current follow-up healthcare focuses on stroke...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
What Factors Determine Treatment Outcome in Aneurysmal Subarachnoid Hemorrhage in the Modern Era? A Post Hoc STASH Analysis.
BACKGROUND: The management of aneurysmal subarachnoid hemorrhage (aSAH) has changed dramatically in the last few decades with the publication of a few major studies, including ISAT (International Subarachnoid Aneurysm Trial, the...
Endovascular coiling Neurosurgical clipping Post hoc analysis Propensity matched analysis aSAH Adolescent Adult Age Factors Aged Angiography Digital Subtraction Anticholesteremic Agents Endovascular Procedures Female Humans International Cooperation Intracranial Aneurysm Male Middle Aged Outcome Assessment Health Care Regression Analysis Risk Factors Simvastatin Subarachnoid Hemorrhage Tomography Scanners X-Ray Computed Treatment Outcome Young Adult
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
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