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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Johannes Lorenz Berg, Bianca Perfler, Stefan Hatzl, Barbara Uhl, Andreas Reinisch, Gudrun Pregartner, Andrea Berghold, Thomas Penz, Michael Schuster, Klaus Geissler, Andreas Prokesch, Carsten Müller-Tidow, Gerald Hoefler, Karl Kashofer, Albert Wölfler, Heinz Sill, Veronica Caraffini, Armin Zebisch
May 06, 2021
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gallipoli, Carsten Müller-Tidow, Cameron S Osborne, George S Vassiliou, Brian JP Huntly
Aug 12, 2021
Animals Base Sequence Chromatin Assembly and Disassembly DNA Neoplasm Disease Models Animal Enhancer Elements Genetic Gene Expression Regulation Leukemic Gene Regulatory Networks Genetic Loci Histones Humans Leukemia Myeloid Acute Mice Inbred C57BL Mutation Nuclear Proteins Nucleophosmin principal component analysis Protein Processing Post-Translational RNA Messenger Transcription Genetic fms-Like Tyrosine Kinase 3
Building Effective Manager-Subordinate Relationships
Melissa K Carsten
Jan 01, 0001
Published by: Winthrop University
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
Three Faculty Awards To Be Given at May Graduation Ceremonies
Winthrop University
Jan 01, 0001
On May 5, President Dan Mahony will present the Jane LaRoche Graduate Faculty Award to Melissa Carsten, an associate professor of management. During the May 7 undergraduate Commencement ceremonies, the president will bestow the...
Published by: Winthrop University
Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study.
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Commencement on Dec. 15 Will Honor Graduates and Kinard Award Winner
Winthrop University
Jan 01, 0001
HIGHLIGHTS President Dan Mahony will present Carsten with the 2018 James Pinckney Kinard and Lee Wicker Kinard Award for Excellence in Teaching during the 11 a.m. ceremony at the Winthrop Coliseum. More than 285 undergraduates...
Published by: Winthrop University
Post-Cartel Tacit Collusion
We experimentally investigate the determinants of post-cartel tacit collusion (PCTC), the effects of PCTC on market outcomes, and potential policy measures aimed at its prevention. PCTC occurs robustly with or without fines or...
Infinite-dimensional bilinear and stochastic balanced truncation with explicit error bounds
Abstract: Along the ideas of Curtain and Glover (in: Bart, Gohberg, Kaashoek (eds) Operator theory and systems, Birkhäuser, Boston, 1986), we extend the balanced truncation method for (infinite-dimensional) linear systems to...
Original Article Balanced truncation Bilinear balanced truncation Stochastic balanced truncation Infinite-dimensional system theory
Published by: Springer London
Whether Social Schema Violations Help or Hurt Creativity Depends on Need for Structure
Although people and events that disconfirm observers' expectancies can increase their creativity, sometimes such social schema violations increase observers' rigidity of thought and undermine creative cognition. Here we...
Aqueous ozonation of furans
Despite the widespread occurrence of furan moieties in synthetic and natural compounds, their fate in aqueous ozonation has not been investigated in detail. Reaction rate constants of seven commonly used furans with ozone...
Whether Social Schema Violations Help or Hurt Creativity Depends on Need for Structure
Although people and events that disconfirm observers' expectancies can increase their creativity, sometimes such social schema violations increase observers' rigidity of thought and undermine creative cognition. Here we...
Aqueous ozonation of furans
Despite the widespread occurrence of furan moieties in synthetic and natural compounds, their fate in aqueous ozonation has not been investigated in detail. Reaction rate constants of seven commonly used furans with ozone...
Improved EEG source localization with Bayesian uncertainty modelling of unknown skull conductivity
Electroencephalography (EEG) source imaging is an ill-posed inverse problem that requires accurate conductivity modelling of the head tissues, especially the skull. Unfortunately, the conductivity values are difficult to...
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