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Results: 112
A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1.
Rachel PJ Lai, Miriam Hock, Jens Radzimanowski, Paul Tonks, David Lutje Hulsik, Gregory Effantin, David J Seilly, Hanna Dreja, Alexander Kliche, Ralf Wagner, Susan W Barnett, Nancy Tumba, Lynn Morris, Celia C LaBranche, David C Montefiori, Michael S Seaman, Jonathan L Heeney, Winfried Weissenhorn
Mar 11, 2016
AIDS HIV-1 HIV-1 gp41 Membrane Fusion Protein Conformation Vaccine Development X-ray Scattering Amino Acid Sequence Animals Antibodies Neutralizing Antibody Affinity Female Guinea Pigs HIV Antibodies HIV Envelope Protein gp41 Humans Immune Sera Immunization Immunoglobulin G Molecular Sequence Data neutron diffraction Protein Structure Tertiary Proteolipids SCATTERING Small Angle
Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants.
Rachel PJ Lai, Michael S Seaman, Paul Tonks, Frank Wegmann, David J Seilly, Simon DW Frost, Celia C LaBranche, David C Montefiori, Antu K Dey, Indresh K Srivastava, Quentin Sattentau, Susan W Barnett, Jonathan L Heeney
Nov 08, 2017
Adjuvant formulations capable of inducing high titer and high affinity antibody responses would provide a major advance in the development of vaccines to viral infections such as HIV-1. Although oil-in-water emulsions, such as...
The Lantern Vol. 5, No. 2, March 1937
Marjorie Brosz, Betty Sacks, Edward L. French, C. Kenneth Snyder, Evelyn Huber, Keith M. Thompson, Jack Maloney, Dorothy Burton, Richard Yahraes, Valerie H. Green, Elizabeth Ballinger, Frank J. Tornetta, Marjorie Bell, Vernon D. Groff, Helen Smith, Jean P. Wingate
Jan 01, 0001
Frame of Mind: An Editorial Sahara Memories Tears of Blood A Review of Gielgud's Hamlet What is This Thing Called Swing Oriental Impressions Campus Rhymes Death of a Soldier Should We Denounce the "Scab" ...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction John Gielgud Hamlet swing music Ursinus Weekly Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Comparison of the Journey II bicruciate stabilised (JII-BCS) and GENESIS II total knee arthroplasty for functional ability and motor impairment
Iain McNamara, Valerie Pomeroy, Allan B Clark, Graham Creelman, Celia Whitehouse, J Wells, B Harry, Toby O Smith, Juliet High, Ann Marie Swart, Celia Clarke
Feb 09, 2023
OBJECTIVES: To determine if a newer design of total knee replacement (TKR) (Journey II BCS) produces superior patient-reported outcomes scores and biomechanical outcomes than the older, more established design (Genesis II)....
Second-order fast-slow dynamics of non-ergodic Hamiltonian systems
A class of fast–slow Hamiltonian systems with potential U ɛ describing the interaction of non-ergodic fast and slow degrees of freedom is studied. The parameter ɛ indicates the typical timescale ratio of the fast...
Asymptotic expansion Coarse-graining Far-from-equilibrium Many-degrees-of-freedom interaction Two-scale Hamiltonian /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2610 name=Mathematical Physics
Harnessing fluctuations to discover dissipative evolution equations
Continuum modeling of dissipative processes in materials often relies on strong phenomenological assumptions, as their derivation from underlying atomistic/particle models remains a major long-standing challenge. Here we show...
Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.
Juan García-Arriaza, Beatriz Perdiguero, Jonathan Heeney, Michael Seaman, David C Montefiori, Celia Labranche, Nicole L Yates, Xiaoying Shen, Georgia D Tomaras, Guido Ferrari, Kathryn E Foulds, Adrian McDermott, Shing-Fen Kao, Mario Roederer, Natalie Hawkins, Steve Self, Jiansheng Yao, Patrick Farrell, Sanjay Phogat, Jim Tartaglia, Susan W Barnett, Brian Burke, Anthony Cristillo, Deborah Weiss, Carter Lee, Karen Kibler, Bert Jacobs, Benedikt Asbach, Ralf Wagner, Song Ding, Giuseppe Pantaleo, Mariano Esteban
Jun 19, 2015
Computing diffusivities from particle models out of equilibrium
A new method is proposed to numerically extract the diffusivity of a (typically nonlinear) diffusion equation from underlying stochastic particle systems. The proposed strategy requires the system to be in local equilibrium and...
Coarse-graining Fluctuation–dissipation non-equilibrium thermodynamics Transport coefficients /dk/atira/pure/subjectarea/asjc/2600/2600 name=General Mathematics /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy
Comparison of the Journey II bicruciate stabilised (JII-BCS) and GENESIS II total knee arthroplasty for functional ability and motor impairment
Iain McNamara, Valerie Pomeroy, Allan B Clark, Graham Creelman, Celia Whitehouse, J Wells, B Harry, Toby O Smith, Juliet High, Ann Marie Swart, Celia Clarke
Jan 10, 2023
IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells.
The timing of Drosophila egg chamber development is controlled by a germline Delta signal that activates Notch in the follicle cells to induce them to cease proliferation and differentiate. Here, we report that follicle cells...
ADAM10 protease Delta Drosophila oogenesis RNA-binding protein Animals Cell Division Cell Polarity Disintegrins Drosophila Proteins Drosophila melanogaster Epistasis Genetic Female Intracellular Signaling Peptides and Proteins Membrane Proteins Metalloendopeptidases MicroRNAs Mutation Ovarian Follicle RNA-Binding Proteins Receptors Notch Signal Transduction Time Factors
Comparing single-best-answer and very-short-answer questions for the assessment of applied medical knowledge in 20 UK medical schools
OBJECTIVES: The study aimed to compare candidate performance between traditional best-of-five single-best-answer (SBA) questions and very-short-answer (VSA) questions, in which candidates must generate their own answers of...
assessment MEDICAL EDUCATION & TRAINING applied medical knowledge Academic performance Clinical Competence Cross-Sectional Studies Decision Making Education Medical Undergraduate Educational Measurement Humans Knowledge learning Schools Medical Students Medical Surveys and Questionnaires United Kingdom
Second-order fast-slow dynamics of non-ergodic Hamiltonian systems
A class of fast–slow Hamiltonian systems with potential U ɛ describing the interaction of non-ergodic fast and slow degrees of freedom is studied. The parameter ɛ indicates the typical timescale ratio of the fast...
Asymptotic expansion Coarse-graining Far-from-equilibrium Many-degrees-of-freedom interaction Two-scale Hamiltonian /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2610 name=Mathematical Physics
The role of trained champions in sustaining and spreading nutrition care improvements in hospital
BACKGROUND: Many patients are already malnourished when admitted to hospital. Barriers and facilitators to nutrition care in hospital have been identified and successful interventions developed; however, few studies have...
Cardiac ion channel expression in the equine model - In-silico prediction utilising RNA sequencing data from mixed tissue samples.
Antoine Premont, Khalil Saadeh, Charlotte Edling, Rebecca Lewis, Celia M Marr, Kamalan Jeevaratnam
Jul 26, 2022
Pre-service teachers’ conceptions of their own learning
We present an analysis of pre-service teachers’ (PSTs) conceptions of their own learning, focusing on relationships between where PSTs learn and conceptions of their own learning. Our data come from in-depth interviews carried...
Harnessing fluctuations to discover dissipative evolution equations
Continuum modeling of dissipative processes in materials often relies on strong phenomenological assumptions, as their derivation from underlying atomistic/particle models remains a major long-standing challenge. Here we show...
Pre-service teachers’ conceptions of their own learning
We present an analysis of pre-service teachers’ (PSTs) conceptions of their own learning, focusing on relationships between where PSTs learn and conceptions of their own learning. Our data come from in-depth interviews carried...
Computing diffusivities from particle models out of equilibrium
A new method is proposed to numerically extract the diffusivity of a (typically nonlinear) diffusion equation from underlying stochastic particle systems. The proposed strategy requires the system to be in local equilibrium and...
Coarse-graining Fluctuation–dissipation non-equilibrium thermodynamics Transport coefficients /dk/atira/pure/subjectarea/asjc/2600/2600 name=General Mathematics /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy
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