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The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
Artificial intelligence and machine learning in cancer imaging.
Dow-Mu Koh, Nickolas Papanikolaou, Ulrich Bick, Rowland Illing, Charles E Kahn, Jayshree Kalpathi-Cramer, Celso Matos, Luis Martí-Bonmatí, Anne Miles, Seong Ki Mun, Sandy Napel, Andrea Rockall, Evis Sala, Nicola Strickland, Fred Prior
Dec 08, 2022
An increasing array of tools is being developed using artificial intelligence (AI) and machine learning (ML) for cancer imaging. The development of an optimal tool requires multidisciplinary engagement to ensure that the...
Trends in therapeutic drug conjugates for bacterial diseases
INTRODUCTION: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted...
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.
Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the...
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209 + dendritic cells for immune T cell areas
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into...
Published by: Rockefeller University
Development of vocal emotion recognition in school-age children
Leanne Nagels, Etienne Gaudrain, Deborah Vickers, Marta Matos Lopes, Petra Hendriks, Deniz Başkent
May 11, 2020
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
Published by: PeerJ
A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging.
Benjamin J Stenton, Bruno L Oliveira, Maria J Matos, Laura Sinatra, Gonçalo JL Bernardes
Jul 02, 2018
We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal decaging. This was enabled by a thioether binding motif in the propargyl...
Facilitating permeability of landscapes impacted by roads for protected amphibians
Amphibian populations are highly vulnerable to road mortality and habitat fragmentation caused by road networks. Wildlife road tunnels are considered the most promising road mitigation measure for amphibians yet generally remain...
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.
Maria J Matos, Carlos Labão-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, Gonçalo JL Bernardes
Sep 05, 2018
Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on...
Development of vocal emotion recognition in school-age children
Leanne Nagels, Etienne Gaudrain, Deborah Vickers, Marta Matos Lopes, Petra Hendriks, Deniz Başkent
May 14, 2020
Traditionally, emotion recognition research has primarily used pictures and videos, while audio test materials are not always readily available or are not of good quality, which may be particularly important for studies with...
Anterior mitral valve leaflet length in cats with hypertrophic cardiomyopathy.
INTRODUCTION: Anterior mitral valve leaflet (AMVL) elongation is a recognised feature of hypertrophic cardiomyopathy (HCM). However, whether AMVL elongation precedes left ventricular hypertrophy in cats is currently unknown. The...
Sequential dual site-selective protein labelling enabled by lysine modification.
Maria J Matos, Libby Brown, Barbara Bernardim, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Sep 25, 2020
Methods that allow for chemical site-selective dual protein modification are scarce. Here, we provide proof-of-concept for the orthogonality and compatibility of a method for regioselective lysine modification with strategies...
Comparison of Normalization Techniques on Data Sets With Outliers
With the fast growth of data-rich systems, dealing with complex decision problems with skewed input data sets and respective outliers is unavoidable. Generally, data skewness refers to a non-uniform distribution in a dataset...
Published by: IGI Global Scientific Publishing
Temperature response of an all-solid photonic bandgap fiber for sensing applications
The spectral shift due to temperature in the photonic bandgap (PBG) of an all-solid PBG fiber is investigated, aiming at discrete and distributed temperature sensing. A temperature rise induces a red shift in the bandgap...
Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points.
Maria L Vainieri, Andrew M Blagborough, Adam L MacLean, Myriam LR Haltalli, Nicola Ruivo, Helen A Fletcher, Michael PH Stumpf, Robert E Sinden, Cristina Lo Celso
Mar 18, 2021
Haematopoiesis is the complex developmental process that maintains the turnover of all blood cell lineages. It critically depends on the correct functioning of rare, quiescent haematopoietic stem cells (HSCs) and more numerous...
Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity
Efficient vaccination against the parasite Leishmania major, the causative agent of human cutaneous leishmaniasis, requires development of type 1 T-helper (Th1) CD4+ T cell immunity. Because of their unique capacity to initiate...
CD4+ T lymphocyte dendritic cell Genetic Engineering Immunization protozoal protein tumor necrosis factor Leishmania major
Published by: Rockefeller University
Temperature response of an all-solid photonic bandgap fiber for sensing applications
The spectral shift due to temperature in the photonic bandgap (PBG) of an all-solid PBG fiber is investigated, aiming at discrete and distributed temperature sensing. A temperature rise induces a red shift in the bandgap...
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery - a cohort study.
Alexandre da Silva Rocha, Juliana Rombaldi Bernardi, Salete Matos, Daniela Cortés Kretzer, Alice Carvalhal Schöffel, Marcelo Zubaran Goldani, José Antônio de Azevedo Magalhães
Apr 30, 2020
BACKGROUND: Gestational diabetes mellitus (GDM) is a common condition, often associated with high maternal and fetal morbidity. The use of new tools for early GDM screening can contribute to metabolic control to reduce maternal...
Global population attributable fraction of potentially modifiable risk factors for mental disorders
Elena Dragioti, Joaquim Radua, Marco Solmi, Celso Arango, Dominic Oliver, Samuele Cortese, Peter B. Jones, Jae Il Shin, Christoph U. Correll, Paolo Fusar-Poli
Apr 07, 2023
Numerous risk factors for mental disorders have been identified. However, we do not know how many disorders we could prevent and to what extent by modifying these risk factors. This study quantifies the Population Attributable...
Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy.
Joonbum Seo, Jessie Rosie Payne, Jose Novo Matos, Wesley Wynne Fong, David J Connolly, Virginia Luis Fuentes
Sep 23, 2021
BACKGROUND: N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (HCM) have...
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
Maria J Matos, Claudio D Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L Saar, Ismael Compañón, Francisco Corzana, Tuomas PJ Knowles, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Apr 05, 2019
Quaternized vinyl- and alkynyl-pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine-tagged proteins at near-stoichiometric quantities. We have demonstrated that this method can...
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
Philip R Lindstedt, Francesco A Aprile, Maria J Matos, Michele Perni, Jean B Bertoldo, Barbara Bernardim, Quentin Peter, Gonzalo Jiménez-Osés, Tuomas PJ Knowles, Christopher M Dobson, Francisco Corzana, Michele Vendruscolo, Gonçalo JL Bernardes
Jul 23, 2019
Protein behavior is closely regulated by a plethora of post-translational modifications (PTMs). It is therefore desirable to develop approaches to design rational PTMs to modulate specific protein functions. Here, we report one...
Chemo- and Regioselective Lysine Modification on Native Proteins.
Maria J Matos, Bruno L Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro MSD Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J Deery, Justin M Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
May 11, 2018
Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site...
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