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![Cover Image for Stoichiometric and catalytic C-F bond activation by the<i> trans</i>-dihydride complex [Ru(IEt<sub>2</sub>Me<sub>2</sub>)<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>H<sub>2</sub>] (IEt<sub>2</sub>Me<sub>2</sub> = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene)](https://coverimages.igi-global.com/images/search-article.png)
Stoichiometric and catalytic C-F bond activation by the<i> trans</i>-dihydride complex [Ru(IEt<sub>2</sub>Me<sub>2</sub>)<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>H<sub>2</sub>] (IEt<sub>2</sub>Me<sub>2</sub> = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene)
Mateusz K. Cybulski, Ian M. Riddlestone, Mary F. Mahon, Timothy J. Woodman, Michael K. Whittlesey
Jan 01, 0001
The room temperature reaction of C6F6 or C6F5H with [Ru(IEt2Me2)2(PPh3)2H¬2] (1; IEt2Me2 = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene) generated a mixture of the trans-hydride fluoride complex [Ru(IEt2Me2)2(PPh3)2HF] (2) and the...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with <i>trans</i>-[Ru(NHC)<sub>4</sub>H<sub>2</sub>] Via a Converted Nucleophlic Ru-H Attack Pathway
The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
Stoichiometric and catalytic C-F bond activation by the<i> trans</i>-dihydride complex [Ru(IEt<sub>2</sub>Me<sub>2</sub>)<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>H<sub>2</sub>] (IEt<sub>2</sub>Me<sub>2</sub> = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene)
Mateusz K. Cybulski, Ian M. Riddlestone, Mary F. Mahon, Timothy J. Woodman, Michael K. Whittlesey
Jan 01, 0001
The room temperature reaction of C6F6 or C6F5H with [Ru(IEt2Me2)2(PPh3)2H¬2] (1; IEt2Me2 = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene) generated a mixture of the trans-hydride fluoride complex [Ru(IEt2Me2)2(PPh3)2HF] (2) and the...
Polyunsaturated fatty acids and prostate cancer risk
Nikhil K Khankari, Harvey J Murff, Chenjie Zeng, Wanqing Wen, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Jenny L Donovan, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Wei Zheng, PRACTICAL Consortium
Dec 01, 2017
BACKGROUND: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been...
Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with <i>trans</i>-[Ru(NHC)<sub>4</sub>H<sub>2</sub>] Via a Converted Nucleophlic Ru-H Attack Pathway
The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand...
Copper-NHC-Mediated Semi-Hydrogenation and Hydroboration of Alkynes
Jonathan Hall, Darcy Unson, Paul Brunel, Lee Collins, Mateusz Cybulski, Mary Mahon, Michael Whittlesey
Sep 24, 2018
A series of two-coordinate copper tert-butoxide complexes bearing five-, six-, and seven-membered ring N-heterocyclic carbenes, prepared by protonolysis of (NHC)CuMes with tBuOH, have been used as catalytic precursors in...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
Copper-NHC-Mediated Semi-Hydrogenation and Hydroboration of Alkynes
Jonathan Hall, Darcy Unson, Paul Brunel, Lee Collins, Mateusz Cybulski, Mary Mahon, Michael Whittlesey
Sep 24, 2018
A series of two-coordinate copper tert-butoxide complexes bearing five-, six-, and seven-membered ring N-heterocyclic carbenes, prepared by protonolysis of (NHC)CuMes with tBuOH, have been used as catalytic precursors in...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
AA9int
Hui-Yi Lin, Po-Yu Huang, Dung-Tsa Chen, Heng-Yuan Tung, Thomas A Sellers, Julio M Pow-Sang, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, David E Neal, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y Park
Sep 21, 2018
MOTIVATION: The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature. We previously proposed...
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Ali Amin Al Olama, Sara Benlloch, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Borge G Nordestgaard, Ruth C Travis, David Neal, Nora Pasayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Koveela Govindasami, Ken Muir, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Rosalind A Eeles, Zsofia Kote-Jarai
May 13, 2016
BRCA1 Protein Case-Control Studies Cell Cycle Proteins DNA DNA Repair DNA Repair Enzymes DNA-Binding Proteins Genes BRCA2 Genetic Predisposition to Disease Genome-Wide Association Study Genotype Germ-Line Mutation Humans Male Polymorphism Single Nucleotide Prospective Studies Prostatic Neoplasms risk
Alcohol consumption and prostate cancer incidence and progression
Clair Brunner, Neil M Davies, Richard M Martin, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Jenny Donovan, Freddie C Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Luisa Zuccolo
Sep 22, 2016
Mendelian randomisation Alcohol alcohol metabolising genes prostate cancer Aged Aged 80 and over Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Dehydrogenase Mitochondrial Case-Control Studies Disease Progression Humans Incidence Linkage Disequilibrium Male Middle Aged Neoplasm Grading Polymorphism Single Nucleotide Prostatic Neoplasms Regression Analysis Retinal Dehydrogenase Survival Analysis
SNP interaction pattern identifier (SIPI)
Hui-Yi Lin, Dung-Tsa Chen, Po-Yu Huang, Yung-Hsin Liu, Augusto Ochoa, Jovanny Zabaleta, Donald E Mercante, Zhide Fang, Thomas A Sellers, Julio M Pow-Sang, Chia-Ho Cheng, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y Park
Jan 12, 2017
KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness.
Hui-Yi Lin, Po-Yu Huang, Chia-Ho Cheng, Heng-Yuan Tung, Zhide Fang, Anders E Berglund, Ann Chen, Jennifer French-Kwawu, Darian Harris, Julio Pow-Sang, Kosj Yamoah, John L Cleveland, Shivanshu Awasthi, Robert J Rounbehler, Travis Gerke, Jasreman Dhillon, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, UKGPCS collaborators, Johanna Schleutker, Nora Pashayan, APCB (Australian Prostate Cancer BioResource), David E Neal, Sune F Nielsen, Børge G Nordestgaard, Henrik Gronberg, Fredrik Wiklund, Graham G Giles, Christopher A Haiman, Ruth C Travis, Janet L Stanford, Adam S Kibel, Cezary Cybulski, Kay-Tee Khaw, Christiane Maier, Stephen N Thibodeau, Manuel R Teixeira, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Hardev Pandha, PRACTICAL Consortium, Srilakshmi Srinivasan, Judith Clements, Jyotsna Batra, Jong Y Park
Apr 29, 2021
Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP-SNP...
A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data.
Manuel Neumann, Xiaocai Xu, Cezary Smaczniak, Julia Schumacher, Wenhao Yan, Nils Blüthgen, Thomas Greb, Henrik Jönsson, Jan Traas, Kerstin Kaufmann, Jose M Muino
May 20, 2022
Cellular heterogeneity in growth and differentiation results in organ patterning. Single-cell transcriptomics allows characterization of gene expression heterogeneity in developing organs at unprecedented resolution. However...
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.
Amy E Taylor, Richard M Martin, Milan S Geybels, Janet L Stanford, Irene Shui, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, William Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Jenny Donovan, Marcus R Munafò
Oct 26, 2016
Carolina Bonilla, Sarah J Lewis, Mari-Anne Rowlands, Tom R Gaunt, George Davey Smith, David Gunnell, Tom Palmer, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Grönberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Mark Lathrop, Richard M Martin, Jeff MP Holly
May 17, 2016
ALSPAC IGFBP3 Mendelian randomization PRACTICAL ProtecT UKHLS insulin-like growth factor-binding proteins insulin-like growth factors prostate cancer SINGLE NUCLEOTIDE POLYMORPHISMS Aged Case-Control Studies Genome-Wide Association Study Humans Insulin-Like Growth Factor Binding Proteins Longitudinal Studies Male Mendelian Randomization Analysis Middle Aged Neoplasm Grading Neoplasm Staging Polymorphism Single Nucleotide Prostatic Neoplasms Somatomedins United Kingdom
Estimating central blood pressure from aortic flow
Jorge Mariscal-Harana, Peter H Charlton, Samuel Vennin, Jorge Aramburu, Mateusz Cezary Florkow, Arna van Engelen, Torben Schneider, Hubrecht de Bliek, Bram Ruijsink, Israel Valverde, Philipp Beerbaum, Heynric Grotenhuis, Marietta Charakida, Phil Chowienczyk, Spencer J Sherwin, Jordi Alastruey
Oct 26, 2020
Central blood pressure (cBP) is a highly prognostic cardiovascular (CV) risk factor whose accurate, invasive assessment is costly and carries risks to patients. We developed and assessed novel algorithms for estimating cBP from...
Blood lipids and prostate cancer
Caroline J Bull, Carolina Bonilla, Jeff MP Holly, Claire M Perks, Neil Davies, Philip Haycock, Oriana Hoi Yun Yu, J Brent Richards, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Robert J Macinnis, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Agnieszka Micheal, Hardev Pandha, George Davey Smith, Sarah J Lewis, Richard M Martin, PRACTICAL Consortium
Aug 09, 2016
Cholesterol Mendelian randomization prostate cancer Statins Case-Control Studies Genetic Association Studies Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Lipids Male Mendelian Randomization Analysis Meta-Analysis as Topic Neoplasm Grading Neoplasm Staging Odds Ratio Polymorphism Single Nucleotide Population Surveillance Prostatic Neoplasms Quantitative Trait Heritable
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.
Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, Kirsten Moysich, Kunle Odunsi, Roberta Ness, Beth Y Karlan, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Ian G Campbell, Conxi Lázaro, Miguel Angel Pujara, Julie Cunningham, Robert Vierkant, Stacey J Winham, Michelle Hildebrandt, Chad Huff, Donghui Li, Xifeng Wu, Yao Yu, Jennifer B Permuth, Douglas A Levine, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Penelope M Webb, Opal Study Group, Cezary Cybulski, Jacek Gronwald, Anna Jakubowska, Jan Lubinski, Jennifer Alsop, Patricia Harrington, Isaac Chan, Usha Menon, Celeste L Pearce, Anna H Wu, Anna de Fazio, Catherine J Kennedy, Ellen Goode, Susan Ramus, Simon Gayther, Paul Pharoah
May 13, 2020
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer
Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, Kirsten Moysich, Kunle Odunsi, Roberta Ness, Beth Y Karlan, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Ian G Campbell, Conxi Lázaro, Miguel Angel Pujara, Julie Cunningham, Robert Vierkant, Stacey J Winham, Michelle Hildebrandt, Chad Huff, Donghui Li, Xifeng Wu, Yao Yu, Jennifer B Permuth, Douglas A Levine, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Penelope M Webb, Opal Study Group, Cezary Cybulski, Jacek Gronwald, Anna Jakubowska, Jan Lubinski, Jennifer Alsop, Patricia Harrington, Isaac Chan, Usha Menon, Celeste L Pearce, Anna H Wu, Anna de Fazio, Catherine J Kennedy, Ellen Goode, Susan Ramus, Simon Gayther, Paul Pharoah
Jun 17, 2020
Purpose: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate...
Pubertal development and prostate cancer risk
Carolina Bonilla, Sarah J Lewis, Richard M Martin, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Mark Lathrop, George Davey Smith, PRACTICAL Consortium
May 11, 2016
Boys Mendelian randomization prostate cancer Puberty Tanner scale Adolescent Age of Onset Aged Case-Control Studies Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Neoplasm Staging Odds Ratio Polymorphism Single Nucleotide Prostatic Neoplasms Puberty Random Allocation Regression Analysis Risk Factors Sexual Maturation Survival Analysis United Kingdom
Polygenic hazard score to guide screening for aggressive prostate cancer
Tyler M Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan Karunamuni, J Kellogg Parsons, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo LJ Tammela, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, M Andreas Røder, Peter Iversen, Tim J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy, Paul Pharoah, Nora Pashayan, Kay-Tee Khaw, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Dominika Wokolorczyk, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Katarina Cuk, Kai-Uwe Saum, Jong Y Park, Thomas A Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, David S Karow, Ian G Mills, Ole A Andreassen, Anders M Dale, PRACTICAL Consortium*
Feb 23, 2018
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to select...
Age of Onset Aged Cohort Studies Disease-Free Survival Early Detection of Cancer Genotype Humans Kallikreins Male Middle Aged Outcome Assessment Health Care Polymorphism Single Nucleotide Predictive Value of Tests Prostate-specific antigen Prostatic Neoplasms Risk Assessment Survival Analysis White People
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