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Results: 28
Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis.
Timothy Fulton, Vikas Trivedi, Andrea Attardi, Kerim Anlas, Chaitanya Dingare, Alfonso Martinez Arias, Benjamin Steventon
May 18, 2020
A fundamental question in developmental biology is how the early embryo establishes the spatial coordinate system that is later important for the organization of the embryonic body plan. Although we know a lot about the...
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L. Blundell
May 21, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Sequence homology and expression profile of genes associated with DNA repair pathways in Mycobacterium leprae.
BACKGROUND: Survival of Mycobacterium leprae, the causative bacteria for leprosy, in the human host is dependent to an extent on the ways in which its genome integrity is retained. DNA repair mechanisms protect bacterial DNA...
Strategies for drug target identification in Mycobacterium leprae.
A Parallel Particle Swarm Optimization for Community Detection in Large Attributed Graphs
Social network analysis (SNA) is an active research domain that mainly deals with large social graphs and their properties. Community detection (CD) is one of the active research topics belonging to this domain. Social graphs in...
Published by: IGI Global Scientific Publishing
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections
Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines...
Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder.
Chaitanya Erady, Krishna Amin, Temiloluwa OAE Onilogbo, Jakub Tomasik, Rebekah Jukes-Jones, Yagnesh Umrania, Sabine Bahn, Sudhakaran Prabakaran
May 12, 2022
Learning the travelling salesperson problem requires rethinking generalization
Abstract End-to-end training of neural network solvers for graph combinatorial optimization problems such as the Travelling Salesperson Problem (TSP) have seen a surge of interest recently, but...
Data Analytic Techniques for Developing Decision Support System on Agrometeorological Parameters for Farmers
The day-to-day lives of humans are changing remarkably due to the evolution in tools, techniques and technology across the planet. This evolution is not only impacting the growth of humans but also contributing to the growth and...
Published by: IGI Global Scientific Publishing
Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.
Stephanie Portelli, Yoochan Myung, Nicholas Furnham, Sundeep Chaitanya Vedithi, Douglas EV Pires, David B Ascher
Sep 28, 2020
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L Blundell
Jul 09, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Modelling outcomes after paediatric brain injury with admission laboratory values
Saeed Kayhanian, Adam MH Young, Chaitanya Mangla, Ibrahim Jalloh, Helen M Fernandes, Matthew R Garnett, Peter J Hutchinson, Shruti Agrawal
Aug 01, 2019
BACKGROUND: Severe traumatic brain injury (TBI) is a leading cause of mortality in children, but the accurate prediction of outcomes at the point of admission remains very challenging. Admission laboratory results are a...
HARP
Sundeep Chaitanya Vedithi, Sony Malhotra, Marcin J Skwark, Asma Munir, Marta Acebrón-García-de-Eulate, Vaishali P Waman, Ali Alsulami, David B Ascher, Tom L Blundell
Nov 20, 2020
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Carlos Hm Rodrigues, Stephanie Portelli, Marcin J Skwark, Madhusmita Das, David B Ascher, Tom L Blundell, Sony Malhotra
Jan 15, 2020
Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations.
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah Ece, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L Blundell
Aug 04, 2020
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and...
Mycobacterial genomics and structural bioinformatics
Vaishali P Waman, Sundeep Chaitanya Vedithi, Sherine E Thomas, Bridget P Bannerman, Asma Munir, Marcin J Skwark, Sony Malhotra, Tom L Blundell
Feb 18, 2019
Of the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium...
Mycobacterium comparative genomics Drug Resistance Mutation structure-guided drug discovery Animals Bacterial Proteins Computational Biology Drug Discovery Drug Resistance Bacterial Genome Bacterial Humans Molecular Sequence Annotation Mycobacterium Mycobacterium abscessus Mycobacterium leprae Mycobacterium tuberculosis Protein Conformation Proteomics Sequence Analysis DNA
COSMIC Cancer Gene Census 3D database
Ali F Alsulami, Pedro HM Torres, Ismail Moghul, Sheikh Mohammed Arif, Amanda K Chaplin, Sundeep Chaitanya Vedithi, Tom L Blundell
Jul 16, 2021
Cancer Gene Census 3D hallmark mutations modelling cancer genes census mutational analyses of cancer drug targets Biomarkers Tumor Computational Biology Data analysis Databases Genetic Humans Models Molecular Mutation Neoplasms Oncogenes Software Structure-Activity Relationship User-Computer Interface Workflow
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae
Sundeep Chaitanya Vedithi, Carlos Hm Rodrigues, Stephanie Portelli, Marcin J Skwark, Madhusmita Das, David B Ascher, Tom L Blundell, Sony Malhotra
Mar 13, 2020
ABSTRACT In contrast to the situation with tuberculosis, rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic methods. A quick and reliable method is essential to determine the...
Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
Sep 27, 2018
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present...
Adolescent Adult Bacterial Proteins DNA Bacterial DNA-Directed RNA Polymerases Drug Resistance Bacterial Female Humans india Leprostatic Agents Leprosy Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium leprae Protein Binding Protein Stability Recurrence Rifampin Sequence Analysis DNA Structure-Activity Relationship Treatment Outcome Young Adult
In silico analysis of mutations near S1/S2 cleavage site in SARS-CoV-2 spike protein reveals increased propensity of glycosylation in Omicron strain.
Christopher A Beaudoin, Arun P Pandurangan, So Yeon Kim, Samir W Hamaia, Christopher L-H Huang, Tom L Blundell, Sundeep Chaitanya Vedithi, Antony P Jackson
Jun 07, 2022
Publisher Correction
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
Aug 05, 2020
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Published by: Sci Rep
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