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Prostate cancer in South Africa
Prostate cancer is one of the most common male cancers globally; however little is known about prostate cancer in Africa. Incidence data for prostate cancer in South Africa (SA) from the pathology based National Cancer Registry...
Understanding polygenic models, their development and the potential application of polygenic scores in healthcare.
The use of genomic information to better understand and prevent common complex diseases has been an ongoing goal of genetic research. Over the past few years, research in this area has proliferated with several proposed methods...
HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa
BACKGROUND: HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of prior HIV...
Analysis of risk factors associated with hepatocellular carcinoma in black South Africans
OBJECTIVE: The aims of this study were to determine the prevalence of risk factors associated with hepatocellular carcinoma (HCC) in black adult South Africans and to estimate the size of the associated risks. METHODS: A...
How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests?
Sowmiya Moorthie, Alison Hall, Chantal Babb de Villiers, Joanna Janus, Tanya Brigden, Laura Blackburn, Mark Kroese
Apr 26, 2022
As common low penetrance variants associated with diseases are uncovered, attempts continue to be made to harness this knowledge for improving healthcare. Polygenic scores have been developed as the mechanism by which knowledge...
How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests?
Sowmiya Moorthie, Alison Hall, Chantal Babb de Villiers, Joanna Janus, Tanya Brigden, Laura Blackburn, Mark Kroese
Mar 15, 2022
As common low penetrance variants associated with diseases are uncovered, attempts continue to be made to harness this knowledge for improving healthcare. Polygenic scores have been developed as the mechanism by which knowledge...
Hematologic malignancies in South Africa 2000-2006
Sara J Schonfeld, Friederike Erdmann, Tracey Wiggill, Elvira Singh, Patricia Kellett, Chantal Babb, Joachim Schüz
Apr 16, 2018
Little is known about the incidence patterns of hematologic malignancies in Sub-Saharan Africa, including South Africa. We estimated incidence rates of pathology-confirmed adult cases of leukemia, myeloma and related diseases...
An evaluation of commercial fluorescent bead-based luminex cytokine assays.
Joel Fleury Djoba Siawaya, Teri Roberts, Chantal Babb, Gillian Black, Hawa Jande Golakai, Kim Stanley, Nchinya Bennedict Bapela, Eileen Hoal, Shreemanta Parida, Paul van Helden, Gerhard Walzl
Apr 16, 2018
The recent introduction of fluorescent bead-based technology, allowing the measurement of multiples analytes in a single 25-50 microl sample has revolutionized the study of cytokine responses. However, such multiplex approaches...
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Luis B Barreiro, Olivier Neyrolles, Chantal L Babb, Ludovic Tailleux, Hélène Quach, Ken McElreavey, Paul D van Helden, Eileen G Hoal, Brigitte Gicquel, Lluis Quintana-Murci
Apr 16, 2018
BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic...
Adult Black People Case-Control Studies Cell Adhesion Molecules Dendritic Cells Female Genetic Predisposition to Disease Humans Lectins C-Type Male Middle Aged Mycobacterium tuberculosis Phylogeny Polymorphism Single Nucleotide Promoter Regions Genetic Receptors Cell Surface Risk Factors South Africa Tuberculosis Pulmonary
Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer
Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P Cunningham, Douglas F Easton, Jennifer G McIntosh, Jon Emery, Marc Tischkowitz, Antonis C Antoniou, Fiona M Walter
Apr 06, 2020
BACKGROUND:There is a growing focus on the development of multi-factorial cancer risk prediction algorithms alongside tools that operationalise them for clinical use. BOADICEA is a breast and ovarian cancer risk prediction model...
Published by: PLOS ONE
The Integrity and Yield of Genomic DNA Isolated from Whole Blood Following Long-Term Storage at -30°C.
Wenlong Carl Chen, Robyn Kerr, Andrew May, Babongile Ndlovu, Anelisa Sobalisa, Sanelisiwe T Duze, Lavania Joseph, Christopher G Mathew, Chantal Babb de Villiers
Jun 25, 2018
Long-term storage of whole blood can affect the integrity of DNA if it is not done under optimal conditions. The aim of this study was to determine whether long-term storage (2-19 years) of whole blood samples at -30°C had a...
CanRisk Tool-A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants.
Tim Carver, Simon Hartley, Andrew Lee, Alex P Cunningham, Stephanie Archer, Chantal Babb de Villiers, Jonathan Roberts, Rod Ruston, Fiona M Walter, Marc Tischkowitz, Douglas F Easton, Antonis C Antoniou
Dec 16, 2020
BACKGROUND: The CanRisk Tool (https://canrisk.org) is the next-generation web interface for the latest version of the BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) state-of-the-art...
BOADICEA
Andrew Lee, Nasim Mavaddat, Amber N Wilcox, Alex P Cunningham, Tim Carver, Simon Hartley, Chantal Babb de Villiers, Angel Izquierdo, Jacques Simard, Marjanka K Schmidt, Fiona M Walter, Nilanjan Chatterjee, Montserrat Garcia-Closas, Marc Tischkowitz, Paul Pharoah, Douglas F Easton, Antonis C Antoniou
Jan 28, 2019
PURPOSE: Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA)...
BOADICEA PRS Breast Cancer rare variants Risk prediction Ataxia Telangiectasia Mutated Proteins BRCA1 Protein BRCA2 Protein Breast Neoplasms Checkpoint Kinase 2 Fanconi Anemia Complementation Group N Protein Female Genetic Predisposition to Disease Genetic Testing Humans Multifactorial Inheritance Mutation Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment Risk Factors
Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer
Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Douglas F. Easton, Jennifer G. McIntosh, Jon Emery, Marc Tischkowitz, Antonis C. Antoniou, Fiona M. Walter
Mar 06, 2020
Background: There is a growing focus on the development of multi-factorial cancer risk prediction algorithms alongside tools that operationalise them for clinical use. BOADICEA is a breast and ovarian cancer risk prediction...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Corinna PMG 655 (= P.Oxy. 2370) fr.1 l. 13 κόσμ[εισα λόγυ]ς
L Prauscello
May 02, 2017
0. Fr. 1 of P.Oxy. 2370 (= MP3
249; LDAB 573), published by Lobel in 1956, is so far the only papyrus
fragment among those extant in Boeotian dialect1
whose authorship can be securely ascribed to
Corinna thanks to the overlap...
Floer Simple Manifolds and L-Space Intervals
An oriented three-manifold with torus boundary admits either no L-space Dehn filling, a unique L-space filling, or an interval of L-space fillings. In the latter case, which we call “Floer simple,” we construct an invariant...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Eugene L. Opie, 1910
The Rockefeller University
Jan 01, 0001
Eugene L. Opie, M.D. Inflammation
Lecture delivered February 10th, 1910
Bacterial Infection inflammation reaction macrophage Lymphatic Vessels polynuclear leucocytes enzyme
Published by: J.B. Lippincott Company
L q -spectra of self-affine measures
Abstract: We study L q -spectra of planar self-affine measures generated by diagonal matrices. We introduce a new technique for constructing and understanding examples based on combinatorial estimates for the exponential growth...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
pedigreejs
Tim Carver, Alex P Cunningham, Chantal Babb de Villiers, Andrew Lee, Simon Hartley, Marc Tischkowitz, Fiona M Walter, Douglas F Easton, Antonis C Antoniou
Jun 08, 2018
MOTIVATION: The collection, management and visualization of clinical pedigree (family history) data is a core activity in clinical genetics centres. However, clinical pedigree datasets can be difficult to manage, as they are...
Frank L. Horsfall, Jr., 1952
The Rockefeller University
Jan 01, 0001
Frank L. Horsfall, Jr. Experiments on chemical alteration of virus infections.
Lecture delivered November 20, 1952
Posted with permission
Published by: Academic Press Inc., Publishers
Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer
Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P Cunningham, Douglas F Easton, Jennifer G McIntosh, Jon Emery, Marc Tischkowitz, Antonis C Antoniou, Fiona M Walter
Mar 06, 2020
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
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