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Results: 2003
Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.
Cancer fragment-based ligand design nuclear transporters protein-protein interactions structure-guided ligand design Binding Sites Cell Cycle Proteins Humans Ligands Microtubule-Associated Proteins Models Molecular Molecular Structure Nuclear Proteins Protein Binding Small Molecule Libraries alpha Karyopherins
A Ten Billion Solar Mass Outflow of Molecular Gas Launched by Radio Bubbles in the Abell 1835 Brightest Cluster Galaxy
B. R. McNamara, H. R. Russell, P. E. J. Nulsen, A. C. Edge, N. W. Murray, R. A. Main, A. N. Vantyghem, F. Combes, A. C. Fabian, P. Salome, C. C. Kirkpatrick, S. A. Baum, J. N. Bregman, M. Donahue, E. Egami, S. Hamer, C. P. O'Dea, J. B. R. Oonk, G. Tremblay, G. M. Voit
Mar 25, 2014
We report ALMA Early Science observations of the Abell 1835 brightest cluster galaxy (BCG) in the CO (3-2) and CO (1-0) emission lines. We detect 5E10 solar masses of molecular gas within 10 kpc of the BCG. Its velocity width of...
Fragment-based approaches to TB drugs.
Fostering a personal-is-political ethics
This article suggests that interviews about past ethical dilemmas or transgressions can foster ethical skills for navigating interlocking power relations. It shows how narratives claiming relative innocence are widespread and...
Foucauldian ethics claims of relative innocence interlocking oppression moral economy Invitational and Narrative Practice
Published by: Memorial University of Newfoundland
Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
Ana Trapero, Angela Pacitto, Daniel Shiu-Hin Chan, Chris Abell, Tom L Blundell, David B Ascher, Anthony G Coyne
Nov 15, 2019
Inosine-5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme involved in nucleotide biosynthesis. Because of its critical role in purine biosynthesis, IMPDH is a drug design target for immunosuppressive, anticancer...
Mass spectrometry for fragment screening.
Fragment-based approaches in chemical biology and drug discovery have been widely adopted worldwide in both academia and industry. Fragment hits tend to interact weakly with their targets, necessitating the use of sensitive...
Fragment-based drug discovery ligand-observed mass spectrometry native mass spectrometry Calorimetry Combinatorial Chemistry Techniques Crystallography X-Ray Drug Design Drug Discovery Fluorometry High-Throughput Screening Assays Humans Ligands Magnetic Resonance Spectroscopy Mass Spectrometry Protein Binding Proteins Small Molecule Libraries Structure-Activity Relationship
The Grizzly, November 8, 2012
Jessica Orbon, Sara Sherr, Dave Muoio, Keith Miles, Alexa LaMontagne, Michael D'Amico, Christine Dobisch, Austin Fox, Amanda Frekot, Courtney Scott, Larissa Coyne, Michael Klazas, Chris Rountree, Marcus Foster
Jan 01, 0001
Hurricane Hits UC, Campus Evacuated Sandy: Climate Change? Alumni Give Back to Ursinus Hillel Fosters an Open Community Christmas Mall New Faculty Members in Residence 2012 Photography Club Returns to Campus Henna Event...
Ursinus College Collegeville Pennsylvania newspaper Hurricane Sandy fund raising Hillel Trinity United Church of Christ Jennifer Stevenson Garrett Hope Photography Club To Write Love on Her Arms Football Swimming Chris Rountree cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Viscoelastic Hydrogel Microfibers Exploiting Cucurbit[8]uril Host-Guest Chemistry and Microfluidics.
Fiber-shaped soft constructs are indispensable building blocks for various 3D functional objects such as hierarchical structures within the human body. The design and fabrication of such hierarchically structured soft materials...
Reorienting objects in Alain Resnais and Chris Marker’s Les Statues Meurent Aussi
JJP O'Dwyer
Dec 11, 2017
Chris Marker’s six-minute film Junkopia (1981) was shot alongside his ambitious feature-length project Sans Soleil/Sunless (1982). While the latter ‘nomadic’ film-text comprises a string of encounters spanning national and...
Structure-activity relationship of the peptide binding-motif mediating the BRCA2
RAD51 X-ray crystallography alanine scanning biophysics/ITC Peptides Protein-Protein Interaction Amino Acid Motifs Amino Acid Sequence BRCA2 Protein Conserved Sequence Humans Models Molecular Mutation Peptides Protein Binding Protein Structure Secondary Rad51 Recombinase Structure-Activity Relationship
Droplet-based microfluidic analysis and screening of single plant cells.
Ziyi Yu, Christian R Boehm, Julian M Hibberd, Chris Abell, Jim Haseloff, Steven J Burgess, Ivan Reyna-Llorens
Aug 16, 2018
Agrobacterium tumefaciens Bacterial Proteins Cell Separation Drug Compounding Equipment Design Gene Expression Regulation Plant Genes Reporter Genomics High-Throughput Screening Assays Hot Temperature Lab-On-A-Chip Devices Luminescent Proteins Marchantia Microfluidic Analytical Techniques Microscopy Fluorescence Plants Genetically Modified Promoter Regions Genetic Protoplasts Single-Cell Analysis Stochastic Processes Transformation Genetic
Spirooxindoles as novel 3D-fragment scaffolds
Fostering a personal-is-political ethics
This article suggests that interviews about past ethical dilemmas or transgressions can foster ethical skills for navigating interlocking power relations. It shows how narratives claiming relative innocence are widespread and...
Published by: Memorial University of Newfoundland
Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self-Recovery.
Biomimetic supramolecular dual networks: By mimicking the structure/function model of titin, integration of dynamic cucurbit[8]uril mediated host-guest interactions with a trace amount of covalent cross-linking leads to...
A Ten Billion Solar Mass Outflow of Molecular Gas Launched by Radio Bubbles in the Abell 1835 Brightest Cluster Galaxy
B. R. McNamara, H. R. Russell, P. E. J. Nulsen, A. C. Edge, N. W. Murray, R. A. Main, A. N. Vantyghem, F. Combes, A. C. Fabian, P. Salome, C. C. Kirkpatrick, S. A. Baum, J. N. Bregman, M. Donahue, E. Egami, S. Hamer, C. P. O'Dea, J. B. R. Oonk, G. Tremblay, G. M. Voit
Mar 25, 2014
We report ALMA Early Science observations of the Abell 1835 brightest cluster galaxy (BCG) in the CO (3-2) and CO (1-0) emission lines. We detect 5E10 solar masses of molecular gas within 10 kpc of the BCG. Its velocity width of...
High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform.
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