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Results: 45
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Analysing multiple cancer samples from an individual patient can provide insight into the way the disease evolves. Monitoring the expansion and contraction of distinct clones helps to reveal the mutations that initiate the...
The impact of health behaviours on incident cardiovascular disease in Europeans and South Asians--a prospective analysis in the UK SABRE study.
Anne Eriksen, Therese Tillin, Laura O'Connor, Soren Brage, Alun Hughes, Jamil Mayet, Paul McKeigue, Peter Whincup, Nish Chaturvedi, Nita G Forouhi
May 18, 2015
Bone biodeterioration-The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community.
Anne Marie Høier Eriksen, Tue Kjærgaard Nielsen, Henning Matthiesen, Christian Carøe, Lars Hestbjerg Hansen, David John Gregory, Gordon Turner-Walker, Matthew James Collins, M Thomas P Gilbert
Oct 29, 2021
Bacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity...
Hyperpolarized 13C MRI
James T Grist, Jack J Miller, Fulvio Zaccagna, Mary A McLean, Frank Riemer, Tomasz Matys, Damian J Tyler, Christoffer Laustsen, Alasdair J Coles, Ferdia A Gallagher
Mar 17, 2020
Cerebral metabolism is tightly regulated and fundamental for healthy neurological function. There is increasing evidence that alterations in this metabolism may be a precursor and early biomarker of later stage disease...
Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances.
James T Grist, Esben SS Hansen, Juan D Sánchez-Heredia, Mary A McLean, Rasmus Tougaard, Frank Riemer, Rolf F Schulte, Joshua D Kaggie, Jan Henrik Ardenkjaer-Larsen, Christoffer Laustsen, Ferdia A Gallagher
Apr 02, 2020
PURPOSE: Calibration of hyperpolarized 13 C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13 C-enriched external phantoms. This study investigated the feasibility of using...
Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.
Jack J Miller, Angus Z Lau, Per Mose Nielsen, Giles McMullen-Klein, Andrew J Lewis, Nichlas Riise Jespersen, Vicky Ball, Ferdia A Gallagher, Carolyn A Carr, Christoffer Laustsen, Hans Erik Bøtker, Damian J Tyler, Marie A Schroeder
Feb 11, 2019
OBJECTIVES: The aim of this study was to determine if hyperpolarized [1,4-13C2]malate imaging could measure cardiomyocyte necrosis after myocardial infarction (MI). BACKGROUND: MI is defined by an acute burst of cellular...
cardiac MRI Energy Metabolism hyperpolarized MR Magnetic Resonance Spectroscopy Necrosis Animals Carbon Isotopes Carbon-13 Magnetic Resonance Spectroscopy Contrast Media Energy Metabolism Fumarates Isolated Heart Preparation Magnetic Resonance Imaging Cine Malates Male Molecular Imaging Myocardial Infarction Myocytes Cardiac Necrosis Predictive Value of Tests Rats Wistar
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Aug 24, 2020
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Feb 08, 2021
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
Technical recommendations for clinical translation of renal MRI
Iosif Mendichovszky, Pim Pullens, Ilona Dekkers, Fabio Nery, Octavia Bane, Andreas Pohlmann, Anneloes de Boer, Alexandra Ljimani, Aghogho Odudu, Charlotte Buchanan, Kanishka Sharma, Christoffer Laustsen, Anita Harteveld, Xavier Golay, Ivan Pedrosa, David Alsop, Sean Fain, Anna Caroli, Pottumarthi Prasad, Susan Francis, Eric Sigmund, Maria Fernández-Seara, Steven Sourbron
Oct 17, 2020
PURPOSE: The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating...
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Feb 02, 2021
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells.
Srinjan Basu, Lisa-Maria Needham, David Lando, Edward JR Taylor, Kai J Wohlfahrt, Devina Shah, Wayne Boucher, Yi Lei Tan, Lawrence E Bates, Olga Tkachenko, Julie Cramard, B Christoffer Lagerholm, Christian Eggeling, Brian Hendrich, Dave Klenerman, Steven F Lee, Ernest D Laue
Aug 14, 2018
A major challenge in single-molecule imaging is tracking the dynamics of proteins or complexes for long periods of time in the dense environments found in living cells. Here, we introduce the concept of using FRET to enhance the...
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Ricardo A Fernandes, Kristina A Ganzinger, Justin C Tzou, Peter Jönsson, Steven F Lee, Matthieu Palayret, Ana Mafalda Santos, Alexander R Carr, Aleks Ponjavic, Veronica T Chang, Charlotte Macleod, B Christoffer Lagerholm, Alan E Lindsay, Omer Dushek, Andreas Tilevik, Simon J Davis, David Klenerman
May 24, 2019
T cell receptor dwell time microvilli receptor triggering single-molecule imaging Animals Antigen-Presenting Cells Host-Pathogen Interactions Humans Immunity Innate Kinetics Ligands Lymphocyte Activation Major Histocompatibility Complex Microvilli Models Theoretical Peptides Phosphorylation Receptors Antigen T-Cell Signal Transduction single molecule imaging T-Lymphocytes
Technical recommendations for clinical translation of renal MRI
Iosif Mendichovszky, Pim Pullens, Ilona Dekkers, Fabio Nery, Octavia Bane, Andreas Pohlmann, Anneloes de Boer, Alexandra Ljimani, Aghogho Odudu, Charlotte Buchanan, Kanishka Sharma, Christoffer Laustsen, Anita Harteveld, Xavier Golay, Ivan Pedrosa, David Alsop, Sean Fain, Anna Caroli, Pottumarthi Prasad, Susan Francis, Eric Sigmund, Maria Fernández‐Seara, Steven Sourbron
Jun 06, 2020
Abstract: Purpose: The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for...
Published by: Springer International Publishing
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine.
Ida M Modvig, Daniel B Andersen, Kaare V Grunddal, Rune E Kuhre, Christoffer Martinussen, Charlotte B Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G Kay, Frank Reimann, Fiona M Gribble, Bolette Hartmann, Kirstine N Bojsen-Møller, Sten Madsbad, Nicolai J Wewer Albrechtsen, Jens J Holst
Jan 24, 2020
OBJECTIVES: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but it is...
Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.
Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A Dekkers, Jean-Paul Vallee, Katja Derlin, Mike Notohamiprodjo, Ruth P Lim, Stefano Palmucci, Suraj D Serai, Joao Periquito, Zhen Jane Wang, Martijn Froeling, Harriet C Thoeny, Pottumarthi Prasad, Moritz Schneider, Thoralf Niendorf, Pim Pullens, Steven Sourbron, Eric E Sigmund
Oct 31, 2020
OBJECTIVES: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential...
13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.
Jack J Miller, James T Grist, Sébastien Serres, James R Larkin, Angus Z Lau, Kevin Ray, Katherine R Fisher, Esben Hansen, Rasmus Stilling Tougaard, Per Mose Nielsen, Jakob Lindhardt, Christoffer Laustsen, Ferdia A Gallagher, Damian J Tyler, Nicola Sibson
Nov 21, 2018
Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies with several early-phase clinical trials in...
Clinical and molecular consequences of disease-associated de novo mutations in SATB2.
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, UK10K consortium, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, DDD Study, David R FitzPatrick
Jun 25, 2018
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different...
The Ground State Electronic Energy of Benzene.
Janus J Eriksen, Tyler A Anderson, J Emiliano Deustua, Khaldoon Ghanem, Diptarka Hait, Mark R Hoffmann, Seunghoon Lee, Daniel S Levine, Ilias Magoulas, Jun Shen, Norm M Tubman, K Birgitta Whaley, Enhua Xu, Yuan Yao, Ning Zhang, Ali Alavi, Garnet Kin-Lic Chan, Martin Head-Gordon, Wenjian Liu, Piotr Piecuch, Sandeep Sharma, Seiichiro L Ten-No, CJ Umrigar, Jürgen Gauss
Oct 12, 2020
We report on the findings of a blind challenge devoted to determining the frozen-core, full configuration interaction (FCI) ground-state energy of the benzene molecule in a standard correlation-consistent basis set of double-ζ...
A genome-wide association study of radiotherapy induced toxicity in head and neck cancer patients identifies a susceptibility locus associated with mucositis.
Line MH Schack, Elnaz Naderi, Laura Fachal, Leila Dorling, Craig Luccarini, Alison M Dunning, Head and Neck Group of the Radiogenomics Consortium, Danish Head and Neck Cancer Group (DAHANCA), Enya HW Ong, Melvin LK Chua, Johannes A Langendijk, Behrooz Z Alizadeh, Jens Overgaard, Jesper Grau Eriksen, Christian Nicolaj Andreassen, Jan Alsner
Apr 04, 2022
Consensus-based technical recommendations for clinical translation of renal BOLD MRI
Octavia Bane, Iosif A. Mendichovszky, Bastien Milani, Ilona A. Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E. Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O. Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A. Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J. Wang, Zbigniew Serafin, Jeff L. Zhang, Susan T. Francis, Steven Sourbron, Andreas Pohlmann, Sean B. Fain, Pottumarthi V. Prasad
Jun 06, 2020
Abstract: Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report...
Published by: Springer International Publishing
Consensus-based technical recommendations for clinical translation of renal BOLD MRI.
Octavia Bane, Iosif A Mendichovszky, Bastien Milani, Ilona A Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J Wang, Zbigniew Serafin, Jeff L Zhang, Susan T Francis, Steven Sourbron, Andreas Pohlmann, Sean B Fain, Pottumarthi V Prasad
Nov 24, 2020
Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the...
Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI
Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A. Dekkers, Jean-Paul Vallee, Katja Derlin, Mike Notohamiprodjo, Ruth P. Lim, Stefano Palmucci, Suraj D. Serai, Joao Periquito, Zhen Jane Wang, Martijn Froeling, Harriet C. Thoeny, Pottumarthi Prasad, Moritz Schneider, Thoralf Niendorf, Pim Pullens, Steven Sourbron, Eric E. Sigmund
Jun 06, 2020
Abstract: Objectives: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI...
Published by: Springer International Publishing
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