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Multidrug resistant enteric fever in South Asia
Christopher M Parry, Isabela Ribeiro, Kamini Walia, Priscilla Rupali, Stephen Baker, Buddha Basnyat
Apr 10, 2019
Investments in newer diagnostics and antimicrobial treatments are critical to improve management of enteric fever in South Asia, say Christopher Parry and colleagues
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Michael E Reschen, Kyle J Gaulton, Da Lin, Elizabeth J Soilleux, Andrew J Morris, Susan S Smyth, Christopher A O'Callaghan
Dec 17, 2018
Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal...
The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus.
BACKGROUND: Diabetes mellitus (DM) in dogs is a common endocrinopathy with a complex genetic architecture. Disease susceptibility in several breeds is associated with polymorphisms in immune response genes, but in the Labrador...
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.
Alexander G Murley, Matthew A Rouse, P Simon Jones, Rong Ye, Frank H Hezemans, Claire O'Callaghan, Polytimi Frangou, Zoe Kourtzi, Catarina Rua, T Adrian Carpenter, Christopher T Rodgers, James B Rowe
Jul 28, 2020
GABA frontotemporal dementia Glutamate Impulsivity progressive supranuclear palsy Aged Aged 80 and over Female Frontotemporal Lobar Degeneration Glutamates Humans INHIBITION Psychological Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neuropsychological Tests Neurotransmitter Agents Reaction Time Supranuclear Palsy Progressive Visual Cortex gamma-Aminobutyric Acid
Exploring the Dynamics of Base-Excited Structures Impacting a Rigid Stop
This paper explores the nonlinear dynamics of a multidegree of freedom (MDoF) structure impacting a rigid stop. The contact mechanics is simplified by continuous sigmoid function idealisation of a lossless spring. By introducing...
Exploring the Dynamics of Base-Excited Structures Impacting a Rigid Stop
This paper explores the nonlinear dynamics of a multidegree of freedom (MDoF) structure impacting a rigid stop. The contact mechanics is simplified by continuous sigmoid function idealisation of a lossless spring. By introducing...
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS)
Finbar J K O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew A. Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, John P. Osborne
Jan 01, 2017
Background: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess...
An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.
Rong Ye, Catarina Rua, Claire O'Callaghan, P Simon Jones, Frank H Hezemans, Sanne S Kaalund, Kamen A Tsvetanov, Christopher T Rodgers, Guy Williams, Luca Passamonti, James B Rowe
Oct 20, 2020
Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using...
Dazzling Organist to Play Byrnes Auditorium July 6
Winthrop University
Jan 01, 0001
The concert is at 5 p.m. July 6 in Byrnes Auditorium. It is a free cultural event. Christopher Houlihan recorded his first two CDs when he was in college.
Published by: Winthrop University
The Grizzly, February 7, 2019
Courtney A DuChene, Jen Joseph, Sam Rosenthal, Shelsea Deravil, Johnny Myers, Sienna Coleman, Kevin Leon, William Wehrs, Mark LeDuc, Gabriela Howell
Jan 01, 0001
Dean Nolan Recalls her 33 Year Career at Ursinus Berman Exhibits Spotlight Opioid Crisis, Patriarchy Senior Alumni Award: Its History and Value Rhiannon Giddens to be 2019 Commencement Speaker Inclusive Community Grant...
Ursinus College Collegeville Pennsylvania newspaper Debbie Nolan Berman Art Museum alumni award Rhiannon Giddens Diversity Christopher Karmilowicz SEI Investments Company Basketball Eric Williams Lydia Konstanzer cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS)
Finbar J K O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew A. Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, John P. Osborne
Jan 01, 2017
Background: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess...
The Ursinus Weekly, April 29, 1918
Musical treat by the Metropolitan Artists Varsity easily wallops Military College nine Chem-Bi banquet a delightful occasion Address of Dr. Christopher Noss Psychology of advertising Scholarship students' recital Ursinus...
Ursinus College Collegeville Pennsylvania newspaper baseball YMCA YWCA cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Cerebellar atrophy in neurodegeneration-a meta-analysis.
Helena M Gellersen, Christine C Guo, Claire O'Callaghan, Rachel H Tan, Saber Sami, Michael Hornberger
Dec 01, 2017
INTRODUCTION: The cerebellum has strong cortical and subcortical connectivity, but is rarely taken into account for clinical diagnosis in many neurodegenerative conditions, particularly in the absence of clinical ataxia. The...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
SIFE Team Declared as 2012 Charlotte Regional Champions
Winthrop University
Jan 01, 0001
This makes the eighth straight year that Winthrop's team has taken first place at regionals. Team members are Deja Frederick, a senior integrated marketing communication major; Kayla Dugger, a junior digital information design...
Published by: Winthrop University
Cognitive training for freezing of gait in Parkinson's disease
Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer YY Szeto, Kaylena A Ehgoetz Martens, James M Shine, Sharon L Naismith, Simon JG Lewis
Sep 05, 2018
The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in...
1103 Clinical Sciences Clinical Clinical Medicine and Science aging Mind and Body Neurosciences Neurodegenerative Clinical Research Brain Disorders Parkinson's Disease Behavioral and Social Science Acquired Cognitive Impairment Mental Health Clinical Trials and Supportive Activities Neurological 6.6 Psychological and behavioural
Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms
Finbar J. K. O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Mario Cortina Borja, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark T Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P. Osborne
Oct 01, 2018
Background: Infantile spasms constitute a severe form of epileptic encephalopathy. In the International Collaborative Infantile Spasms Study (ICISS), we showed that combining vigabatrin with hormonal therapy was more...
Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE
Abstract The steady-state localisation of proteins provides vital insight into their function. These localisations are context specific with proteins translocating between different subcellular...
Oliver M Crook, Colin TR Davies, Lisa M Breckels, Josie A Christopher, Laurent Gatto, Paul DW Kirk, Kathryn S Lilley
Oct 10, 2022
Screening Job Candidates With Social Media
With the proliferation of social media, job candidate screening and evaluation professionals have new avenues to gather information regarding job candidates. Job candidates recognize that recruiters will examine their social...
Published by: IGI Global Scientific Publishing
Long-time Winthrop Groundskeeper Passes Away Over the Weekend
Winthrop University
Jan 01, 0001
Long-time Groundskeeper Justin Christopher passed away on Sunday, Nov. 6. He had been a loyal and faithful employee for 16 years. A Celebration of Life service will be held on Thursday, Nov. 10 at 11 a.m. at Mount Holly United...
Published by: Winthrop University
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