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Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes.
Cervical carcinogenesis is characterized by a clonal selection process in which the high-risk human papillomavirus (HRHPV) genome usually changes from the extra-chromosomal (episomal) state seen in productive infections to DNA...
human papillomavirus integration selection Cell Line Cell Proliferation Cell Shape Cell Transformation Viral Cervix Uteri Chromatin Assembly and Disassembly DNA Replication DNA Viral Female Gene Dosage Gene Expression Regulation Viral Genotype Human papillomavirus 16 Humans Keratinocytes Oncogene Proteins Viral Papillomavirus E7 Proteins Papillomavirus Infections Phenotype RNA Messenger RNA Viral Repressor Proteins Time Factors Up-Regulation Uterine Cervical Neoplasms Virus Integration Virus Replication
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.
Maria M Caffarel, Anasuya Chattopadhyay, Angela M Araujo, Julien Bauer, Cinzia G Scarpini, Nicholas Coleman
Aug 19, 2020
Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome. Cervical SCC cells that over-express OSMR show enhanced responsiveness...
cell migration Fibronectin integrin-α5β1 invasion oncostatin M receptor squamous cell carcinoma tissue transglutaminase Blotting Western Carcinoma Squamous Cell Female Fibronectins Fluorescent Antibody Technique GTP-Binding Proteins Humans Immunohistochemistry Immunoprecipitation Integrin alpha5beta1 Microscopy Confocal Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Protein Glutamine gamma Glutamyltransferase 2 Real-Time Polymerase Chain Reaction Receptors Oncostatin M Signal Transduction Tissue Array Analysis Transglutaminases Up-Regulation Uterine Cervical Neoplasms
A high-throughput computational framework for identifying significant copy number aberrations from array comparative genomic hybridisation data.
Ian Roberts, Stephanie A Carter, Cinzia Scarpini, Konstantina Karagavriilidou, Jenny CJ Barna, Mark Calleja, Nicholas Coleman
Aug 19, 2020
Published by: Advances in bioinformatics
Chronic Hepatitis B Virus Infection
Phaedra M Tachtatzis, Aileen Marshall, Aloysious Arvinthan, Suman Verma, Sue Penrhyn-Lowe, Marianna Mela, Cinzia Scarpini, Susan E Davies, Nicholas Coleman, Graeme JM Alexander
Aug 19, 2020
BACKGROUND: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.
Ethan L Morgan, Christopher W Wasson, Lucy Hanson, David Kealy, Ieisha Pentland, Victoria McGuire, Cinzia Scarpini, Nicholas Coleman, J Simon C Arthur, Joanna L Parish, Sally Roberts, Andrew Macdonald
Jul 16, 2018
Human papillomaviruses (HPV) activate a number of host factors to control their differentiation-dependent life cycles. The transcription factor signal transducer and activator of transcription (STAT)-3 is important for cell...
Case-Control Studies Cell Differentiation Cells Cultured DNA-Binding Proteins Female Genome Viral Host-Pathogen Interactions Human papillomavirus 18 Humans Keratinocytes Oncogene Proteins Viral Papillomavirus Infections Phosphorylation STAT3 Transcription Factor Squamous Intraepithelial Lesions of the Cervix Uterine Cervical Neoplasms Virus Replication
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA (piRNA) expression in gonadal malignant germ cell tumours.
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis
Ian J. Groves, Emma L. A. Drane, Marco Michalski, Jack M. Monahan, Cinzia G. Scarpini, Stephen P. Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J. Enright, Nicholas Coleman
Sep 14, 2021
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered...
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
Ian J Groves, Emma L A Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Sep 25, 2021
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered...
Published by: PLoS pathogens
A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis.
Helminth Microbiota Profiling Using Bacterial 16S rRNA Gene Amplicon Sequencing
Symbiont microbial communities play important roles in animal biology and are thus considered integral components of metazoan organisms, including parasitic worms (helminths). Nevertheless, the study of helminth microbiomes has...
Tirana as an Open Lab
The event we are facing at a global scale, the COVID-19 pandemic, can be considered a real death blow to the real markets, in general, as well as to a local heritage-based tourism market, in particular. The closing of both near...
Published by: IGI Global Scientific Publishing
HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the integrated virus genome.
Cell Line Tumor Chromatin Chromatin Assembly and Disassembly Cyclin-Dependent Kinase 9 Epigenesis Genetic Female Gene Expression Regulation Neoplastic Gene Expression Regulation Viral Genome Viral Human papillomavirus 16 Humans Oncogene Proteins Viral Papillomavirus E7 Proteins Repressor Proteins Uterine Cervical Neoplasms Virus Integration
Lipoprotein lipase is frequently overexpressed or translocated in cervical squamous cell carcinoma and promotes invasiveness through the non-catalytic C terminus.
BACKGROUND: We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS: The rearranged genes were...
Suppression of inflammation by helminths
helminth-induced suppression of inflammation hookworms host–parasite interactions microbial richness Microbiota whipworms Ancylostomatoidea Animals Celiac disease Disease Models Animal Gastrointestinal Microbiome Helminths host-parasite interactions Humans Immunosuppression Therapy Inflammation Inflammatory Bowel Diseases Trichuris
Classic Models for New Perspectives
Whilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that...
Comparative Transcriptomics Reveals Clues for Differences in Pathogenicity between Hysterothylacium aduncum, Anisakissimplex sensu stricto and Anisakis pegreffii.
Serena Cavallero, Fabrizio Lombardo, Marco Salvemini, Antonella Pizzarelli, Cinzia Cantacessi, Stefano D'Amelio
Mar 18, 2020
Ascaridoid nematodes are widespread in marine fishes. Despite their major socioeconomic importance, mechanisms associated to the fish-borne zoonotic disease anisakiasis are still obscure. RNA-Seq and de-novo assembly were herein...
MICHELINdb
Riccardo Scotti, Stuart Southern, Christine Boinett, Timothy P Jenkins, Alba Cortés, Cinzia Cantacessi
Jan 06, 2020
BACKGROUND: The complex network of interactions occurring between gastrointestinal (GI) and extra-intestinal (EI) parasitic helminths of humans and animals and the resident gut microbial flora is attracting increasing attention...
Helminth-microbiota cross-talk - A journey through the vertebrate digestive system.
The gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, i.e., the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition...
Bacterial 16S rRNA sequencing Gastrointestinal Tract Helminth-microbiota interactions Lactobacilli Microbial diversity microbial richness Prevotella Ancylostomatoidea Animals Ascaris Gastrointestinal Tract Helminths host-parasite interactions Humans Immunity mucosal Intestinal Mucosa Intestine Large Intestine Small Lactobacillus Microbiota Nematoda Platyhelminths Schistosoma Stomach strongyloides stercoralis Trematoda Trichuris
Cost of Coexisting with a Relict Large Carnivore Population
Andrea Galluzzi, Valerio Donfrancesco, Gianluca Mastrantonio, Cinzia Sulli, Paolo Ciucci
May 21, 2021
Human-carnivore conflicts are a major conservation issue. As bears are expanding their range in Europe’s human-modified landscapes, it is increasingly important to understand, prevent, and address human-bear conflicts and...
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