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Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium...
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Rule Extraction in Trained Feedforward Deep Neural Networks
Explainability is a key aspect of machine learning, necessary for ensuring transparency and trust in decision-making processes. As machine learning models become more complex, the integration of neural and symbolic approaches...
The Trust in Voting Systems (TVS) Measure
It is essential to democracy that voters trust voting systems enough to participate in elections and use these systems. Unfortunately, voter trust has been found to be low in many situations, which could detrimentally impact...
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD
Abstract: The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised...
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Reimagining the Audience-Dancer Relationship Through Mobile Augmented Reality
The research and development of an augmented reality (AR) application for Vancouver-based dance company Small Stage challenged a team of students at a graduate digital media program to understand how AR might reinvent the...
The Grizzly, March 3, 2005
Students Connect at the Job and Internship Fair Who's Teaching Your Class Today? Jet Heiko of Turn Your Back on Bush Visits UC Davis Lecturer Stresses Oral Tradition "The Stories of Our Lives": Presentation by Reverend...
Published by: Ursinus College
A Case Study on the Integration of Cannabis Law Enforcement in New Jersey
Legalized medical cannabis is implemented in 44 states in the USA while recreational marijuana legislation has challenged the law enforcement community. The public safety concerns of citizens involve a perceived increase in...
Beneath Time and Reflection
Claudia Serban
Dec 21, 2016
Ever since The Essence of Manifestation (1963), Michel Henry’s phenomenologydeveloped in a close dialogue with Husserl. This confrontation led Henry, in 1995,to formulate the project of a “non-intentional phenomenology,” which...
Beneath Time and Reflection
Claudia Serban
Dec 21, 2016
Ever since The Essence of Manifestation (1963), Michel Henry’s phenomenologydeveloped in a close dialogue with Husserl. This confrontation led Henry, in 1995,to formulate the project of a “non-intentional phenomenology,” which...
Reviewing the Social GRACES
The Social Graces framework is increasingly used within training institutions, as a means of encouraging learners to critically explore issues of social difference. Attending to issues of power and diversity is believed to help...
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Reviewing the Social GRACES
The Social Graces framework is increasingly used within training institutions, as a means of encouraging learners to critically explore issues of social difference. Attending to issues of power and diversity is believed to help...
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Acetylcholine-modulated plasticity in reward-driven navigation
Neuromodulation plays a fundamental role in the acquisition of new behaviours. In previous experimental work, we showed that acetylcholine biases hippocampal synaptic plasticity towards depression, and the subsequent application...
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Phagophores evolve from recycling endosomes.
The membrane origins of autophagosomes have been a key unresolved question in the field. The earliest morphologically recognizable structure in the macroautophagy/autophagy itinerary is the double-membraned cup-shaped...
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