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Results: 277
Assessing general cognitive and adaptive abilities in adults with Down syndrome
Sarah Hamburg, Bryony Lowe, Carla Marie Startin, Concepcion Padilla, Antonia Coppus, Wayne Silverman, Juan Fortea, Shahid Zaman, Elizabeth Head, Benjamin L Handen, Ira Lott, Weihong Song, André Strydom
Aug 29, 2020
BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on...
Cortical atrophy and amyloid and tau deposition in Down syndrome
Concepcion Padilla, Victor Montal, Madeleine J Walpert, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Sigan L Hartley, Ann D Cohen, Dana L Tudorascu, Bradley T Christian, Benjamin L Handen, William E Klunk, Anthony J Holland, Shahid H Zaman
Apr 01, 2022
Abstract: Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at...
Intra-individual variation of clozapine and norclozapine plasma levels in clinical practice.
INTRODUCTION: Clozapine plasma levels are useful to monitor drug compliance, and also to assess and to prevent some side effects. Recently, routine monitoring to all clozapine-treated patients has been proposed to prevent...
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J Walpert, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Bradley T Christian, Benjamin L Handen, William E Klunk, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
May 23, 2019
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J Walpert, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Bradley T Christian, Benjamin L Handen, William E Klunk, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
Feb 07, 2020
Introduction:Comorbid Alzheimer disease pathologies are frequently found in people with Down syndrome (DS). We report a deep phenotyping study undertaken over 7 years in a participant with DS who was nondemented at baseline but...
The Role of Language in Structuring Social Networks Following Market Integration in a Yucatec Maya Population.
Language is the human universal mode of communication, and is dynamic and constantly in flux accommodating user needs as individuals interface with a changing world. However, we know surprisingly little about how language...
Geographical and social isolation drive the evolution of Austronesian languages.
The origins of linguistic diversity remain controversial. Studies disagree on whether group features such as population size or social structure accelerate or decelerate linguistic differentiation. While some analyses of...
Active Blended Learning
This chapter focuses on the joint implementation of blended learning and active learning. The authors analysed 152 institutional websites containing definitions of these concepts. Blended learning is commonly, though arguably...
Published by: IGI Global Scientific Publishing
Trazodone and patient outcomes in dementia-Limitations of naturalistic cohort data.
Emad Sidhom, Mc Stephen Padilla, Jonathan Lewis, Simon White, John T O'Brien, Giovanna R Mallucci, Benjamin R Underwood
Aug 03, 2022
The unfolded protein response has been increasingly implicated as an important pathological pathway and target for therapeutic intervention in neurodegeneration. The licensed antidepressant trazodone is one drug which has been...
Changing language input following market integration in a Yucatec Mayan community
Like many indigenous populations worldwide, Yucatec Maya communities are rapidly undergoing change as they become more connected with urban centers and access to formal education, wage labour, and market goods became more...
Changing language input following market integration in a Yucatec Mayan community.
Like many indigenous populations worldwide, Yucatec Maya communities are rapidly undergoing change as they become more connected with urban centers and access to formal education, wage labour, and market goods became more...
Population interconnectivity over the past 120,000 years explains distribution and diversity of Central African hunter-gatherers.
Cecilia Padilla-Iglesias, Lane M Atmore, Jesús Olivero, Karen Lupo, Andrea Manica, Epifanía Arango Isaza, Lucio Vinicius, Andrea Bamberg Migliano
Jun 18, 2022
The evolutionary history of African hunter-gatherers holds key insights into modern human diversity. Here, we combine ethnographic and genetic data on Central African hunter-gatherers (CAHG) to show that their current...
Identifying Patterns and Sources of Fine and Ultrafine Particulate Matter in London Using Mobile Measurements of Lung-Deposited Surface Area.
Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults
Paula Duarte de Oliveira, Fernando César Wehrmeister, Bernardo Lessa Horta, Rogelio Pérez-Padilla, Giovanny Vinícius Araújo de França, Denise P Gigante, Fernando C Barros, Ken K Ong, Emanuella De Lucia Rolfe, Ana Maria Baptista Menezes
Feb 07, 2018
BACKGROUND: Several studies have verified body fat distribution in association with pulmonary function (PF), mainly waist circumference, but few have used measures able to distinguish abdominal fat compartments. The present...
abdominal adiposity Body composition Pulmonary function Visceral adiposity Abdomen Adult Body Fat Distribution Brazil Cross-Sectional Studies Female Forced Expiratory Volume Humans Intra-Abdominal Fat Linear Models Lung Male Multivariate Analysis Spirometry Subcutaneous Fat Ultrasonography Vital Capacity
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
Chemical and Carbon Isotopic Characterization of a Karst-Dominated Urbanized Watershed
Urbanization and agriculture are two key factors that place demands on water resources and serve as sources of anthropogenic pollution into inland waterways. The San Antonio River, which is sourced from a karst aquifer, plays an...
Published by: Digital Commons @ Texas A&M University-San Antonio
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
Ana Monteagudo-Sánchez, Jose Ramon Hernandez Mora, Carlos Simon, Adam Burton, Jair Tenorio, Pablo Lapunzina, Stephen Clark, Manel Esteller, Gavin Kelsey, Juan Pedro López-Siguero, Guiomar Perez de Nanclares, Maria-Elena Torres-Padilla, David Monk
Jan 11, 2021
Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals...
Beckwith-Wiedemann syndrome Cohort Studies DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Embryo Mammalian Genomic Imprinting Germ Cells Humans Microarray Analysis Mutation Oocytes Pedigree pseudohypoparathyroidism RNA-seq Repressor Proteins Siblings Transcriptome Tripartite Motif-Containing Protein 28
Rare non-Hodgkin lymphoma of childhood and adolescence
Andishe Attarbaschi, Oussama Abla, Laura Arias Padilla, Auke Beishuizen, GA Amos Burke, Laurence Brugières, Julie Bruneau, Birgit Burkhardt, Emanuele SG d'Amore, Wolfram Klapper, Udo Kontny, Marta Pillon, Mary Taj, Suzanne D Turner, Anne Uyttebroeck, Wilhelm Woessmann, Karin Mellgren
May 04, 2020
Pediatric-type follicular (PTFL), marginal zone (MZL), and peripheral T-cell lymphoma (PTCL) account each for <2% of childhood non-Hodgkin lymphoma. We present clinical and histopathological features of PTFL, MZL, and few...
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.
Patrick Beckert, Elisabeth Sanchez-Padilla, Matthias Merker, Viola Dreyer, Thomas A Kohl, Christian Utpatel, Claudio U Köser, Ivan Barilar, Nazir Ismail, Shaheed Vally Omar, Marisa Klopper, Robin M Warren, Harald Hoffmann, Gugu Maphalala, Elisa Ardizzoni, Bouke C de Jong, Bernhard Kerschberger, Birgit Schramm, Sönke Andres, Katharina Kranzer, Florian P Maurer, Maryline Bonnet, Stefan Niemann
Nov 25, 2020
BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the...
Diagnostice escape MDR outbreak strains multidrug resistance Resistance evolution Treatment escape Treatment Failure Tuberculosis Antitubercular Agents Bacterial Proteins Clone Cells Diarylquinolines Disease Outbreaks Eswatini Humans Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Tuberculosis Multidrug-Resistant
The 2023 terahertz science and technology roadmap
A Leitenstorfer, AS Moskalenko, T Kampfrath, J Kono, E Castro-Camus, K Peng, N Qureshi, D Turchinovich, K Tanaka, AG Markelz, M Havenith, C Hough, HJ Joyce, WJ Padilla, B Zhou, KY Kim, XC Zhang, PU Jepsen, S Dhillon, M Vitiello, E Linfield, AG Davies, MC Hoffmann, R Lewis, M Tonouchi, P Klarskov, TS Seifert, YA Gerasimenko, D Mihailovic, R Huber, JL Boland, O Mitrofanov, P Dean, BN Ellison, PG Huggard, SP Rea, C Walker, DT Leisawitz, JR Gao, C Li, Q Chen, G Valušis, VP Wallace, E Pickwell-Macpherson, X Shang, J Hesler, N Ridler, CC Renaud, I Kallfass, T Nagatsuma, JA Zeitler, D Arnone, MB Johnston, J Cunningham
Apr 06, 2023
The 2023 Terahertz Science and Technology Roadmap
Alfred Leitenstorfer, Andrey S Moskalenko, Tobias Kampfrath, Junichiro Kono, Enrique Castro-Camus, Kun Peng, Naser Qureshi, Dmitry Turchinovich, Koichiro Tanaka, Andrea Markelz, Martina Havenith, Cameron Hough, Hannah J Joyce, Willie Padilla, Binbin Zhou, Ki-Yong Kim, Xi-Cheng Zhang, Peter Uhd Jepsen, Sukhdeep Dhillon, Miriam Serena Vitiello, Edmund H Linfield, Alexander Giles Davies, Matthias Hoffmann, Roger Lewis, Masayoshi Tonouchi, Pernille Klarskov, Tom Seifert, Yaroslav Gerasimenko, Dragan D Mihailovic, Rupert Huber, Jessica Boland, Oleg Mitrofanov, Paul Dean, Brian Ellison, Peter Huggard, Simon Rea, Christopher Walker, David Leisawitz, Jian Rong Gao, Chong Li, Qin Chen, Gintaras Valusis, Vincent Patrick Wallace, Emma MacPherson, Xiaobang Shang, Jeffrey Hesler, Nick Ridler, Cyril Renaud, Ingmar Kallfass, Tadao Nagatsuma, Axel Zeitler, Don Arnone, Michael Johnston, John Cunningham
Apr 05, 2023
Emergence of methicillin resistance predates the clinical use of antibiotics.
Jesper Larsen, Claire L Raisen, Xiaoliang Ba, Nicholas J Sadgrove, Guillermo F Padilla-González, Monique SJ Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C Arendrup, Rasmus K Hare, Céline Barnadas, Marc Stegger, Raphael N Sieber, Robert L Skov, Andreas Petersen, Øystein Angen, Sophie L Rasmussen, Carmen Espinosa-Gongora, Frank M Aarestrup, Laura J Lindholm, Suvi M Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J Teale, Andrew S Waller, Bruno Pichon, Martin D Curran, Matthew J Ellington, John J Welch, Sharon J Peacock, David J Seilly, Fiona JE Morgan, Julian Parkhill, Nazreen F Hadjirin, Jodi A Lindsay, Matthew TG Holden, Giles F Edwards, Geoffrey Foster, Gavin K Paterson, Xavier Didelot, Mark A Holmes, Ewan M Harrison, Anders R Larsen
Feb 24, 2022
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought...
Emergence of methicillin resistance predates the clinical use of antibiotics.
Jesper Larsen, Claire L Raisen, Xiaoliang Ba, Nicholas J Sadgrove, Guillermo F Padilla-González, Monique SJ Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C Arendrup, Rasmus K Hare, Céline Barnadas, Marc Stegger, Raphael N Sieber, Robert L Skov, Andreas Petersen, Øystein Angen, Sophie L Rasmussen, Carmen Espinosa-Gongora, Frank M Aarestrup, Laura J Lindholm, Suvi M Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J Teale, Andrew S Waller, Bruno Pichon, Martin D Curran, Matthew J Ellington, John Welch, Sharon Peacock, David J Seilly, Fiona Morgan, Julian Parkhill, Nazreen F Hadjirin, Jodi A Lindsay, Matthew TG Holden, Giles F Edwards, Geoffrey Foster, Gavin K Paterson, Xavier Didelot, Mark Holmes, Ewan Harrison, Anders R Larsen
Feb 03, 2022
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought...
A connectome and analysis of the adult Drosophila central brain.
Louis K Scheffer, C Shan Xu, Michal Januszewski, Zhiyuan Lu, Shin-Ya Takemura, Kenneth J Hayworth, Gary B Huang, Kazunori Shinomiya, Jeremy Maitlin-Shepard, Stuart Berg, Jody Clements, Philip M Hubbard, William T Katz, Lowell Umayam, Ting Zhao, David Ackerman, Tim Blakely, John Bogovic, Tom Dolafi, Dagmar Kainmueller, Takashi Kawase, Khaled A Khairy, Laramie Leavitt, Peter H Li, Larry Lindsey, Nicole Neubarth, Donald J Olbris, Hideo Otsuna, Eric T Trautman, Masayoshi Ito, Alexander S Bates, Jens Goldammer, Tanya Wolff, Robert Svirskas, Philipp Schlegel, Erika Neace, Christopher J Knecht, Chelsea X Alvarado, Dennis A Bailey, Samantha Ballinger, Jolanta A Borycz, Brandon S Canino, Natasha Cheatham, Michael Cook, Marisa Dreher, Octave Duclos, Bryon Eubanks, Kelli Fairbanks, Samantha Finley, Nora Forknall, Audrey Francis, Gary Patrick Hopkins, Emily M Joyce, SungJin Kim, Nicole A Kirk, Julie Kovalyak, Shirley A Lauchie, Alanna Lohff, Charli Maldonado, Emily A Manley, Sari McLin, Caroline Mooney, Miatta Ndama, Omotara Ogundeyi, Nneoma Okeoma, Christopher Ordish, Nicholas Padilla, Christopher M Patrick, Tyler Paterson, Elliott E Phillips, Emily M Phillips, Neha Rampally, Caitlin Ribeiro, Madelaine K Robertson, Jon Thomson Rymer, Sean M Ryan, Megan Sammons, Anne K Scott, Ashley L Scott, Aya Shinomiya, Claire Smith, Kelsey Smith, Natalie L Smith, Margaret A Sobeski, Alia Suleiman, Jackie Swift, Satoko Takemura, Iris Talebi, Dorota Tarnogorska, Emily Tenshaw, Temour Tokhi, John J Walsh, Tansy Yang, Jane Anne Horne, Feng Li, Ruchi Parekh, Patricia K Rivlin, Vivek Jayaraman, Marta Costa, Gregory SXE Jefferis, Kei Ito, Stephan Saalfeld, Reed George, Ian A Meinertzhagen, Gerald M Rubin, Harald F Hess, Viren Jain, Stephen M Plaza
Nov 20, 2020
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include...
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