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Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
Connor A Emdin, Amit V Khera, Derek Klarin, Pradeep Natarajan, Seyedeh M Zekavat, Akihiro Nomura, Mary Haas, Krishna Aragam, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Padhraig Gormley, Aarno Palotie, Nathan O Stitziel, Namrata Gupta, John Danesh, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jan 19, 2018
BACKGROUND: Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for...
cardiovascular disease Genetics Nitric oxide nitric oxide synthase blood pressure Coronary Disease Genetic Association Studies Genetic Predisposition to Disease Humans Mutation Nitric oxide Nitric Oxide Synthase Type III Peripheral Arterial Disease Phenotype Polymorphism Single Nucleotide Protective factors Risk Factors Signal Transduction Soluble Guanylyl Cyclase stroke
Decomposing the Humanities
S Connor
Feb 07, 2017
Drawing deeply from the example of Michel Serres, Bruno Latour’s work represents a critique of the commitment to critique which has become the dominant mode of much work in the humanities. Latour’s An Inquiry into Modes of...
A Discrete Morse Approach for Computing Homotopy Types: An Exploration of the Morse, Generalized Morse, Matching, and Independence Complexes
Connor Donovan
Jan 01, 0001
In this thesis, we study possible homotopy types of four families of simplicial complexes-the Morse complex, the generalized Morse complex, the matching complex, and the independence complex-using discrete Morse theory. Given a...
Morse complex matchings strong collapses homotopy type chord diagrams Geometry and Topology mathematics Physical Sciences and Mathematics
Published by: Ursinus College
Towards the Homotopy Type of the Morse Complex
Connor Donovan
Jan 01, 0001
Mathematicians have long been interested in studying the properties of simplicial complexes. In 1998, Robin Forman developed gradient vector fields as a tool to study these complexes. Having gradient vector fields to study these...
Discrete Morse Theory Morse complex simplicial complex Strong Collapsibility Geometry and Topology mathematics Physical Sciences and Mathematics
Published by: Ursinus College
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.
Akihiro Nomura, Connor A Emdin, Hong Hee Won, Gina M Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, Heribert Schunkert, Adolfo Correa, Matthew J Bown, Nilesh J Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Roberto Elosua, Masa-Aki Kawashiri, Hayato Tada, Namrata Gupta, Svati H Shah, Daniel J Rader, Stacey Gabriel, Amit V Khera, Sekar Kathiresan
Dec 17, 2020
Coronary Artery Disease Lipids Odds Ratio Pedigree prevalence ATP Binding Cassette Transporter Subfamily G Member 5 ATP Binding Cassette Transporter Subfamily G Member 8 Adult Case-Control Studies Cholesterol LDL Coronary Artery Disease Female Heterozygote Humans Hypercholesterolemia Intestinal Diseases Lipid Metabolism Inborn Errors Lipoproteins Loss of Function Mutation Male Middle Aged Odds Ratio Phytosterols Risk Factors Sitosterols
A Brief Introduction to Chemical Reaction Optimization.
Connor J Taylor, Alexander Pomberger, Kobi C Felton, Rachel Grainger, Magda Barecka, Thomas W Chamberlain, Richard A Bourne, Christopher N Johnson, Alexei A Lapkin
Mar 23, 2023
From the start of a synthetic chemist's training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist to develop practical skills and some...
Entanglement consumption of instantaneous nonlocal quantum measurements
Relativistic causality has dramatic consequences on the measurability of nonlocal variables and poses the fundamental question of whether it is physically meaningful to speak about the value of nonlocal variables at a particular...
Entanglement consumption of instantaneous nonlocal quantum measurements
Relativistic causality has dramatic consequences on the measurability of nonlocal variables and poses the fundamental question of whether it is physically meaningful to speak about the value of nonlocal variables at a particular...
Characterizing the Interaction of MAGUK Scaffold Protein PSD-95 With Synaptic Adhesion Protein Slitrk2
Connor Loomis
Jan 01, 0001
In the developing nervous system, synapse formation is crucial to establish proper brain wiring and therefore function. At synapses, several pre- and postsynaptic adhesion proteins are expressed to coordinate synapse formation....
synapse formation postsynaptic adhesion proteins Slitrk2 MAGUK scaffold proteins PSD-95 yeast two-hybrid assay Biology Cell Biology Life Sciences Molecular and Cellular Neuroscience
Published by: Ursinus College
The Three Billy Goats Gruff
Connor Renfroe
Jan 01, 0001
A prose story
Anthology Winthrop Literary Journal Arts Journal Arts Magazine Literary Magazine Magazine art poetry prose Creative Writing fiction
Published by: Winthrop University
Communicating Climate to Ourselves and Others
Connor Bernier
Jan 01, 0001
My Summer Fellows experience has focused on the essential importance of communication in the climate crisis, and on personal exploration to reconnect with the natural world. Grounding practices such as hiking in the woods and...
Climate Communication frameworks autoethnography Social Media Valley Forge Chanticleer communication Environmental Studies
Published by: Ursinus College
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Response to Letter: "Pediatric Obesity-Assessment, Treatment, and Prevention
Dennis M Styne, Silva A Arslanian, Ellen L Connor, Ismaa Sadaf Farooqi, M Hassan Murad, Janet H Silverstein, Jack A Yanovski
Aug 02, 2019
Penalized smoothing splines resolve the curvature identifiability problem in age-period-cohort models with unequal intervals
Age-period-cohort (APC) models are frequently used in a variety of health and demographic-related outcomes. Fitting and interpreting APC models to data in equal intervals (equal age and period widths) is nontrivial due to the...
age-period-cohort models identifiability penalized smoothing splines unequal intervals /dk/atira/pure/subjectarea/asjc/2700/2713 name=Epidemiology /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Pediatric Obesity-Assessment, Treatment, and Prevention
Dennis M Styne, Silva A Arslanian, Ellen L Connor, Ismaa Sadaf Farooqi, M Hassan Murad, Janet H Silverstein, Jack A Yanovski
Aug 02, 2019
Cosponsoring Associations: The European Society of Endocrinology and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the assessment...
Penalized smoothing splines resolve the curvature identifiability problem in age-period-cohort models with unequal intervals
Age-period-cohort (APC) models are frequently used in a variety of health and demographic-related outcomes. Fitting and interpreting APC models to data in equal intervals (equal age and period widths) is nontrivial due to the...
age-period-cohort models identifiability penalized smoothing splines unequal intervals /dk/atira/pure/subjectarea/asjc/2700/2713 name=Epidemiology /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Expert Elicitation of Multinomial Probabilities for Decision-Analytic Modeling
BACKGROUND: Expert elicitation is required to inform decision making when relevant "better quality" data either do not exist or cannot be collected. An example of this is to inform decisions as to whether to screen for melanoma....
Peeling
Connor Renfroe
Jan 01, 0001
A poem
Winthrop Anthology Creative Writing art poetry prose writing Magazine Literary Magazine Creative Writing poetry
Published by: Winthrop University
Bronze Soldier
Connor Renfroe
Jan 01, 0001
A poem
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Creative Writing poetry
Published by: Winthrop University
Yeast: The Gateway to Redefining and Improving Biology Labs
Connor Loomis
Jan 01, 0001
Building off of collegiate research performed during the summer of 2018, this lesson plan outlines a lab for secondary students using yeast. Yeast is an affordable and convenient organism to introduce to secondary education, and...
Lesson plans yeast growth secondary education lab protocols biology learning standards Data Collection Data analysis primary scientific literature Biology Cell Biology Curriculum and Instruction Educational Assessment, Evaluation, and Research Educational Methods Science and Mathematics Education secondary education
Published by: Ursinus College
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread.
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Oct 15, 2021
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
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