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The artificial pancreas
Conor Farrington
Jul 18, 2019
Research into closed-loop systems is advancing, but many issues remain. Conor Farrington reports.
After a long lead-in period, artificial pancreas technology is well on its way to revolutionising the treatment of diabetes. The...
Epigenetic activation of meiotic recombination near Arabidopsis thaliana centromeres via loss of H3K9me2 and non-CG DNA methylation.
Charles J Underwood, Kyuha Choi, Christophe Lambing, Xiaohui Zhao, Heïdi Serra, Filipe Borges, Joe Simorowski, Evan Ernst, Yannick Jacob, Ian R Henderson, Robert A Martienssen
Jun 04, 2018
Eukaryotic centromeres contain the kinetochore, which connects chromosomes to the spindle allowing segregation. During meiosis, centromeres are suppressed for inter-homolog crossover, as recombination in these regions can cause...
Some transpose-free CG-like solvers for nonsymmetric ill-posed problems
This paper introduces and analyzes an original class of Krylov subspace methods that provide an efficient alternative to many well-known conjugate-gradient-like (CG-like) Krylov solvers for square nonsymmetric linear systems...
Some transpose-free CG-like solvers for nonsymmetric ill-posed problems
This paper introduces and analyzes an original class of Krylov subspace methods that provide an efficient alternative to many well-known conjugate-gradient-like (CG-like) Krylov solvers for square nonsymmetric linear systems...
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P Singh, Marta C Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A Del Pozo, Robert G Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Jan 06, 2020
Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that...
Multi-instrumental analysis of large sprite events and their producing storm in southern France
S. Soula, F. Iacovella, O. van der Velde, J. Montanyà, M. Füllekrug, T. Farges, J. Bór, J.-F. Georgis, S. NaitAmor, J.-M. Martin
Jan 01, 2014
During the night of 01-02 September, 2009, seventeen distinct sprite events including 3 halos were observed above a storm in north-western Mediterranean Sea, with a video camera at Pic du Midi (42.93N; 0.14E; 2877 m). The...
Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.
Short-term hyperglycemia suppresses superior cervical ganglia neurotransmission. If this ganglionic dysfunction also occurs in the islet sympathetic pathway, sympathetically mediated glucagon responses could be impaired. Our...
WLDS celiac ganglia fos Glucagon nicotinic acetylcholine receptors Norepinephrine sympathetic nervous system Animals Diabetes mellitus Type 1 Down-Regulation Electric Stimulation Ganglia Sympathetic Ganglionic Stimulants Glucagon Hyperglycemia Islets of Langerhans Male Mutant Proteins Nerve Tissue Proteins Neurons Nicotinic Agonists Norepinephrine Proto-Oncogene Proteins c-fos Rats Sprague-Dawley Rats Transgenic Rats Wistar Receptors Nicotinic Synaptic Transmission Wallerian degeneration
A Feminist Critique on the Limits of Rawls
Conor Arsenault
Jan 05, 2017
The general aim of this paper is to elaborate on the political philosophy of John Rawls, specifically his concepts such as the original position, the veil of ignorance, and the difference principle. In clarifying these concepts...
Published by: Memorial University of Newfoundland
An AI Using Construction Grammar to Understand Text
Denis Kiselev
Apr 01, 2021
This paper describes an AI that uses construction grammar (CG)—a means of knowledge representation for deep understanding of text. The proposed improvements aim at more versatility of the text form and meaning knowledge...
Published by: IGI Global Scientific Publishing
Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways.
Gagan D Gupta, Gautam Dey, MG Swetha, Balaji Ramalingam, Khader Shameer, Joseph Jose Thottacherry, Joseph Mathew Kalappurakkal, Mark T Howes, Ruma Chandran, Anupam Das, Sindhu Menon, Robert G Parton, R Sowdhamini, Mukund Thattai, Satyajit Mayor
Jan 06, 2020
Single-cell-resolved measurements reveal heterogeneous distributions of clathrin-dependent (CD) and -independent (CLIC/GEEC: CG) endocytic activity in Drosophila cell populations. dsRNA-mediated knockdown of core versus...
Multi-instrumental analysis of large sprite events and their producing storm in southern France
S. Soula, F. Iacovella, O. van der Velde, J. Montanyà, M. Füllekrug, T. Farges, J. Bór, J.-F. Georgis, S. NaitAmor, J.-M. Martin
Jan 01, 2014
During the night of 01-02 September, 2009, seventeen distinct sprite events including 3 halos were observed above a storm in north-western Mediterranean Sea, with a video camera at Pic du Midi (42.93N; 0.14E; 2877 m). The...
A Cloud-Edge Collaborative Gaming Framework Using AI-Powered Foveated Rendering and Super Resolution
Cloud gaming (CG) has gradually gained popularity. By leveling shared computing resources on the cloud, CG technology allows those without expensive hardware to enjoy AAA games using a low-end device. However, the bandwidth...
Published by: IGI Global Scientific Publishing
Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent.
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Apr 12, 2019
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in...
A Feminist Critique on the Limits of Rawls
Conor Arsenault
Jan 05, 2017
The general aim of this paper is to elaborate on the political philosophy of John Rawls, specifically his concepts such as the original position, the veil of ignorance, and the difference principle. In clarifying these concepts...
Published by: Memorial University of Newfoundland
A method to challenge symmetries in data with self-supervised learning
Abstract Symmetries are key properties of physical models and of experimental designs, but any proposed symmetry may or may not be realized in nature. In this paper, we introduce a practical and...
Constrained invariant mass distributions in cascade decays. The shape of the "m(qll)-threshold" and similar distributions
CG Lester
Jan 12, 2010
Considering the cascade decay $D\to c C \to c b B \to c b a A$ in which
$D,C,B,A$ are massive particles and $c,b,a$ are massless particles, we
determine for the first time the shape of the distribution of the invariant
mass of...
Chronic Stress Effects on Prefrontal Cortical Structure and Function
Conor Liston
Jan 01, 0001
Stressful life events have been implicated clinically in the pathogenesis of major depression, but the neural substrates that may account for this observation remain poorly understood. Attentional impairments symptomatic of...
Published by: Rockefeller University
Literalising Metaphor in the Poetry of Robert Southwell
<sup>☆</sup>
Conor McKee
Jun 07, 2022
Abstract: This article focuses on a distinctive feature of Robert Southwell's poetic technique, namely, his approach to metaphor. I argue that a number of Southwell's metaphors have a surprisingly literal quality where their...
Leadership off the pitch
Research question: The first-team manager’s position in semi-professional or professional football clubs can be viewed as the de-facto leadership role. Although there has been considerable research conducted in relation to...
Many-Body Coarse-Grained Interactions Using Gaussian Approximation Potentials.
We introduce a computational framework that is able to describe general many-body coarse-grained (CG) interactions of molecules and use it to model the free energy surface of molecular liquids as a cluster expansion in terms of...
Non-Coding RNA Features Critical to the Replication of HIV-1
Matthew A Takata
Jan 01, 0001
The HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication including, but not limited to transcription, splicing, nuclear export, translation, packaging and reverse transcription....
Published by: Rockefeller University
Measuring the Higgs boson mass in dileptonic W-boson decays at hadron colliders
It is expected that hadron collider measurements of the Higgs boson mass
using the decay h -> W^+W^-, followed by the leptonic decay of each W-boson,
will be performed by fitting the shape of a distribution which is sensitive...
Weighing wimps with kinks at colliders
We consider the application of endpoint techniques to the problem of mass
determination for new particles produced at a hadron collider, where these
particles decay to an invisible particle of unknown mass and one or...
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