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XVIIth Little Brain Big Brain
Little Brain Big Brain is a biannual meeting organized and attended by young investigators. Since its inception in 1989, this meeting has brought together promising junior researchers in neurogastroenterology. The XVIIth meeting...
Patterns of the fecal microbiota in the Juan Fernández fur seal (Arctocephalus philippii).
Constanza Toro-Valdivieso, Frederick Toro, Samuel Stubbs, Eduardo Castro-Nallar, Barbara Blacklaws
Jul 28, 2021
As apex predators, pinnipeds are considered to be useful bioindicators of marine and coastal environments. Endemic to a small archipelago in the South Pacific, the Juan Fernandez fur seal (JFFS) is one of the less-studied...
Autism screening and conditional cash transfers in Chile
Andres Roman-Urrestarazu, Carolina Yáñez, Claudia López-Garí, Constanza Elgueta, Carrie Allison, Carol Brayne, Mónica Troncoso, Simon Baron-Cohen
May 11, 2021
Diagnosis of Autism Spectrum Conditions (ASC) can be an extended procedure since ASC tend to both vary greatly across individual symptoms and diagnostic pathways with serious challenges to opportune access and diagnosis in low...
Autism screening and conditional cash transfers in Chile
Andres Roman-Urrestarazu, Carolina Yáñez, Claudia López-Garí, Constanza Elgueta, Carrie Allison, Carol Brayne, Mónica Troncoso, Simon Baron-Cohen
Dec 23, 2020
Heavy metal contamination in pristine environments
Constanza Toro-Valdivieso, Ravin Jugdaohsingh, Jonathan J. Powell, Joseph I. Hoffman, Jaume Forcada, Charles Moore, Barbara Blacklaws
Mar 28, 2023
Ecology conservation and global change biology RESEARCH ARTICLES Cadmium Mercury silicon Heavy metals marine mammal pinniped
Published by: The Royal Society
First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors.
Richard D Baird, Constanza Linossi, Mark Middleton, Simon Lord, Adrian Harris, Jordi Rodón, Christof Zitt, Ulrike Fiedler, Keith M Dawson, Nicolas Leupin, Michael T Stumpp, Andreas Harstrick, Analía Azaro, Stefanie Fischer, Aurelius Omlin
Dec 11, 2020
PURPOSE: A first-in-human study was performed with MP0250, a DARPin drug candidate. MP0250 specifically inhibits both vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) with the aim of disrupting the...
Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data.
Sriganesh Jammula, Annalise C Katz-Summercorn, Xiaodun Li, Constanza Linossi, Elizabeth Smyth, Sarah Killcoyne, Daniele Biasci, Vinod V Subash, Sujath Abbas, Adrienn Blasko, Ginny Devonshire, Amber Grantham, Filip Wronowski, Maria O'Donovan, Nicola Grehan, Matthew D Eldridge, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Rebecca C Fitzgerald
Jun 05, 2020
BACKGROUND & AIMS: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about...
antitumor immune response gene repression prognostic factor response to treatment Adenocarcinoma Aged Antineoplastic Agents Barrett Esophagus Cyclin E DNA Methylation Disease Progression Epigenesis Genetic Esophageal Mucosa Esophageal Neoplasms Female Gene Amplification Gene Expression Regulation Neoplastic Humans Male Middle Aged Oncogene Proteins Promoter Regions Genetic RNA-seq Retrospective Studies Temozolomide whole genome sequencing
POSEIDON Trial Phase 1b Results
Richard D Baird, Annelot GJ van Rossum, Mafalda Oliveira, Karin Beelen, Meiling Gao, Mariette Schrier, Ingrid AM Mandjes, Javier Garcia-Corbacho, Anne-Laure Vallier, Greig Dougall, Erik Van Werkhoven, Constanza Linossi, Sanjeev Kumar, Harm van Tinteren, Maurizio Callari, Emma Beddowes, José-Manuel Perez-Garcia, Hilde Rosing, Else Platte, Petra Nederlof, Margaret Schot, Aurelia de Vries Schultink, René Bernards, Cristina Saura, William Gallagher, Javier Cortès, Carlos Caldas, Sabine C Linn
Oct 02, 2019
PURPOSE: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently...
Adult Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Breast Neoplasms Circulating Tumor DNA Female Humans Imidazoles Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Oxazepines Receptors Estrogen Receptors Progesterone Retreatment Tamoxifen Treatment Outcome
The first horse herders and the impact of early Bronze Age steppe expansions into Asia.
Peter de Barros Damgaard, Rui Martiniano, Jack Kamm, J Víctor Moreno-Mayar, Guus Kroonen, Michaël Peyrot, Gojko Barjamovic, Simon Rasmussen, Claus Zacho, Nurbol Baimukhanov, Victor Zaibert, Victor Merz, Arjun Biddanda, Ilja Merz, Valeriy Loman, Valeriy Evdokimov, Emma Usmanova, Brian Hemphill, Andaine Seguin-Orlando, Fulya Eylem Yediay, Inam Ullah, Karl-Göran Sjögren, Katrine Højholt Iversen, Jeremy Choin, Constanza de la Fuente, Melissa Ilardo, Hannes Schroeder, Vyacheslav Moiseyev, Andrey Gromov, Andrei Polyakov, Sachihiro Omura, Süleyman Yücel Senyurt, Habib Ahmad, Catriona McKenzie, Ashot Margaryan, Abdul Hameed, Abdul Samad, Nazish Gul, Muhammad Hassan Khokhar, OI Goriunova, Vladimir I Bazaliiskii, John Novembre, Andrzej W Weber, Ludovic Orlando, Morten E Allentoft, Rasmus Nielsen, Kristian Kristiansen, Martin Sikora, Alan K Outram, Richard Durbin, Eske Willerslev
Oct 30, 2020
The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyzed 74 ancient...
The population history of northeastern Siberia since the Pleistocene.
Martin Sikora, Vladimir V Pitulko, Vitor C Sousa, Morten E Allentoft, Lasse Vinner, Simon Rasmussen, Ashot Margaryan, Peter de Barros Damgaard, Constanza de la Fuente, Gabriel Renaud, Melinda A Yang, Qiaomei Fu, Isabelle Dupanloup, Konstantinos Giampoudakis, David Nogués-Bravo, Carsten Rahbek, Guus Kroonen, Michaël Peyrot, Hugh McColl, Sergey V Vasilyev, Elizaveta Veselovskaya, Margarita Gerasimova, Elena Y Pavlova, Vyacheslav G Chasnyk, Pavel A Nikolskiy, Andrei V Gromov, Valeriy I Khartanovich, Vyacheslav Moiseyev, Pavel S Grebenyuk, Alexander Yu Fedorchenko, Alexander I Lebedintsev, Sergey B Slobodin, Boris A Malyarchuk, Rui Martiniano, Morten Meldgaard, Laura Arppe, Jukka U Palo, Tarja Sundell, Kristiina Mannermaa, Mikko Putkonen, Verner Alexandersen, Charlotte Primeau, Nurbol Baimukhanov, Ripan S Malhi, Karl-Göran Sjögren, Kristian Kristiansen, Anna Wessman, Antti Sajantila, Marta Mirazon Lahr, Richard Durbin, Rasmus Nielsen, David J Meltzer, Laurent Excoffier, Eske Willerslev
Nov 05, 2020
Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through...
The prehistoric peopling of Southeast Asia.
Hugh McColl, Fernando Racimo, Lasse Vinner, Fabrice Demeter, Takashi Gakuhari, J Víctor Moreno-Mayar, George van Driem, Uffe Gram Wilken, Andaine Seguin-Orlando, Constanza de la Fuente Castro, Sally Wasef, Rasmi Shoocongdej, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Mohd Mokhtar Saidin, Morten E Allentoft, Takehiro Sato, Anna-Sapfo Malaspinas, Farhang A Aghakhanian, Thorfinn Korneliussen, Ana Prohaska, Ashot Margaryan, Peter de Barros Damgaard, Supannee Kaewsutthi, Patcharee Lertrit, Thi Mai Huong Nguyen, Hsiao-Chun Hung, Thi Minh Tran, Huu Nghia Truong, Giang Hai Nguyen, Shaiful Shahidan, Ketut Wiradnyana, Hiromi Matsumae, Nobuo Shigehara, Minoru Yoneda, Hajime Ishida, Tadayuki Masuyama, Yasuhiro Yamada, Atsushi Tajima, Hiroki Shibata, Atsushi Toyoda, Tsunehiko Hanihara, Shigeki Nakagome, Thibaut Deviese, Anne-Marie Bacon, Philippe Duringer, Jean-Luc Ponche, Laura Shackelford, Elise Patole-Edoumba, Anh Tuan Nguyen, Bérénice Bellina-Pryce, Jean-Christophe Galipaud, Rebecca Kinaston, Hallie Buckley, Christophe Pottier, Simon Rasmussen, Tom Higham, Robert A Foley, Marta Mirazón Lahr, Ludovic Orlando, Martin Sikora, Maude E Phipps, Hiroki Oota, Charles Higham, David M Lambert, Eske Willerslev
Oct 31, 2018