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Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro
Revascularisation is a key step for tissue regeneration and complete organ engineering. We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix preparation from human platelets able to support the...
Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro
Revascularisation is a key step for tissue regeneration and complete organ engineering. We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix preparation from human platelets able to support the...
The Efficacy of the Tabby Improved Prevention and Intervention Program in Reducing Cyberbullying and Cybervictimization among Students.
Background. This article presents results from the evaluation of the Tabby Improved Prevention and Intervention Program (TIPIP) for cyberbullying and cybervictimization. TIPIP is theoretically designed to address cyberbullying...
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Aug 08, 2020
Abstract: Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the...
Gastronomic Purism: Immigrant Erasure in the Italian-American Potluck
Jordan Costanza
Jan 01, 0001
Through the lens of the Italian immigration epoch colloquially known as "The Great Arrival," this paper explicates the relationship between the Italian immigrant experience in the U.S. and its corollary of Italian-American...
Published by: Winthrop University
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Gabriele Civiletto, Sukru Anil Dogan, Raffaele Cerutti, Gigliola Fagiolari, Maurizio Moggio, Costanza Lamperti, Cristiane Benincá, Carlo Viscomi, Massimo Zeviani
Dec 17, 2018
The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism. Here, we show that prolonged rapamycin treatment improved...
Autophagy lysosomal biogenesis mTORC1 mitochondrial disease rapamycin Animals Autophagy Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Electron Transport Complex IV Lysosomes Mice Inbred C57BL Mice Knockout Mitochondria Mitochondrial Myopathies Motor Activity Muscles Organelle Biogenesis Phenotype Rilmenidine Sirolimus TOR Serine-Threonine Kinases
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K Srivastava, Nathan Harmston, Kirill Shkura, Owen JL Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul JR Barton, Leanne E Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A Cook, Enrico Petretto
Aug 20, 2019
Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart...
Adolescent Adult Aged Animals Cardiomyopathies Extracellular Matrix Proteins Female Fibrosis Gene Expression Regulation Gene Regulatory Networks Genetic Predisposition to Disease Heart Diseases Humans Male Mice Mice Transgenic Middle Aged Protein Isoforms Smad2 Protein Transforming Growth Factor beta Ubiquitin-Protein Ligases Young Adult
A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy
RNASEH1 Mutations Impair mtDNA Replication and Cause Adult-Onset Mitochondrial Encephalomyopathy.
Aurelio Reyes, Laura Melchionda, Alessia Nasca, Franco Carrara, Eleonora Lamantea, Alice Zanolini, Costanza Lamperti, Mingyan Fang, Jianguo Zhang, Dario Ronchi, Sara Bonato, Gigliola Fagiolari, Maurizio Moggio, Daniele Ghezzi, Massimo Zeviani
Jun 06, 2019
Adult Amino Acid Sequence Base Sequence Blotting Southern Blotting Western DNA Replication DNA Mitochondrial Female High-Throughput Nucleotide Sequencing Humans Male Middle Aged Mitochondrial Encephalomyopathies Molecular Sequence Data Mutation Ophthalmoplegia Chronic Progressive External Pedigree RNA Ribonuclease H
New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies.
Andrea Legati, Aurelio Reyes, Alessia Nasca, Federica Invernizzi, Eleonora Lamantea, Valeria Tiranti, Barbara Garavaglia, Costanza Lamperti, Anna Ardissone, Isabella Moroni, Alan Robinson, Daniele Ghezzi, Massimo Zeviani
Jul 03, 2019
Next Generation Sequencing (NGS) technologies are revolutionizing the diagnostic screening for rare disease entities, including primary mitochondrial disorders, particularly those caused by nuclear gene defects. NGS approaches...
E4F1 mitochondrial disorders Next generation sequencing Whole exome sequencing Adolescent Amino Acid Sequence Child Child Preschool Cohort Studies DNA Mitochondrial Electron Transport Electron Transport Chain Complex Proteins Exome Female Gene Expression Heterozygote High-Throughput Nucleotide Sequencing Homozygote Humans Infant Male Mitochondria Mitochondrial Diseases Molecular Sequence Data Mutation Repressor Proteins Sequence Alignment Ubiquitin-Protein Ligases Young Adult
p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R Merlo
Feb 28, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO)...
Lipomatosis Incidence and Characteristics in an Italian Cohort of Mitochondrial Patients.
Olimpia Musumeci, Emanuele Barca, Costanza Lamperti, Serenella Servidei, Giacomo Pietro Comi, Maurizio Moggio, Tiziana Mongini, Gabriele Siciliano, Massimiliano Filosto, Elena Pegoraro, Guido Primiano, Dario Ronchi, Liliana Vercelli, Daniele Orsucci, Luca Bello, Massimo Zeviani, Michelangelo Mancuso, Antonio Toscano
May 09, 2019
Lipomas have often been associated with mtDNA mutations and were mainly observed in patients with mutation in mitochondrial tRNAlysine which is also the most frequent mutation associated with MERRF. Up to date, no systematic...
Pareto optimal metabolic engineering for the growth-coupled overproduction of sustainable chemicals.
Matteo N Amaradio, Varun Ojha, Giorgio Jansen, Massimo Gulisano, Jole Costanza, Giuseppe Nicosia
Apr 21, 2022
Our research aims to help industrial biotechnology develop a sustainable economy using green technology based on microorganisms and synthetic biology through two case studies that improve metabolic capacity in yeast models...
Community established best practice recommendations for tephra studies-from collection through analysis.
Kristi L Wallace, Marcus I Bursik, Stephen Kuehn, Andrei V Kurbatov, Peter Abbott, Costanza Bonadonna, Katharine Cashman, Siwan M Davies, Britta Jensen, Christine Lane, Gill Plunkett, Victoria C Smith, Emma Tomlinson, Thor Thordarsson, J Douglas Walker
Sep 02, 2022
Tephra is a unique volcanic product with an unparalleled role in understanding past eruptions, long-term behavior of volcanoes, and the effects of volcanism on climate and the environment. Tephra deposits also provide spatially...
Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck.
Ian J Wilson, Phillipa J Carling, Charlotte L Alston, Vasileios I Floros, Angela Pyle, Gavin Hudson, Suzanne CEH Sallevelt, Costanza Lamperti, Valerio Carelli, Laurence A Bindoff, David C Samuels, Passorn Wonnapinij, Massimo Zeviani, Robert W Taylor, Hubert JM Smeets, Rita Horvath, Patrick F Chinnery
Jan 18, 2016
Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities
Edoardo Picetti, Fausto Catena, Fikri Abu-Zidan, Luca Ansaloni, Rocco A Armonda, Miklosh Bala, Zsolt J Balogh, Alessandro Bertuccio, Walt L Biffl, Pierre Bouzat, Andras Buki, Davide Cerasti, Randall M Chesnut, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Carlo Coniglio, Enrico Fainardi, Deepak Gupta, Jennifer M Gurney, Gregory WJ Hawrylux, Raimund Helbok, Peter JA Hutchinson, Corrado Iaccarino, Angelos Kolias, Ronald W Maier, Matthew J Martin, Geert Meyfroidt, David O Okonkwo, Frank Rasulo, Sandro Rizoli, Andres Rubiano, Juan Sahuquillo, Valerie G Sams, Franco Servadei, Deepak Sharma, Lori Shutter, Philip F Stahel, Fabio S Taccone, Andrew Udy, Tommaso Zoerle, Vanni Agnoletti, Francesca Bravi, Belinda De Simone, Yoram Kluger, Costanza Martino, Ernest E Moore, Massimo Sartelli, Dieter Weber, Chiara Robba
Feb 10, 2023
BACKGROUND: Severe traumatic brain-injured (TBI) patients should be primarily admitted to a hub trauma center (hospital with neurosurgical capabilities) to allow immediate delivery of appropriate care in a specialized...
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers
Costanza Paoletti, Gaia Schiavon, Emily M Dolce, Elizabeth P Darga, T Hedley Carr, Joseph Geradts, Matthias Hoch, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Shethah Morgan, Parul Patel, Vicky Rowlands, Nitharsan Sathiyayogan, Kimberly Aung, Erika Hamilton, Manish Patel, Anne Armstrong, Komal Jhaveri, Seock-Ah Im, Nadia Iqbal, Fouziah Butt, Caroline Dive, Elizabeth A Harrington, J Carl Barrett, Richard Baird, Daniel F Hayes
Nov 16, 2018
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER...
Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities
Edoardo Picetti, Fausto Catena, Fikri Abu-Zidan, Luca Ansaloni, Rocco A Armonda, Miklosh Bala, Zsolt J Balogh, Alessandro Bertuccio, Walt L Biffl, Pierre Bouzat, Andras Buki, Davide Cerasti, Randall M Chesnut, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Carlo Coniglio, Enrico Fainardi, Deepak Gupta, Jennifer M Gurney, Gregory WJ Hawryluk, Raimund Helbok, Peter JA Hutchinson, Corrado Iaccarino, Angelos Kolias, Ronald W Maier, Matthew J Martin, Geert Meyfroidt, David O Okonkwo, Frank Rasulo, Sandro Rizoli, Andres Rubiano, Juan Sahuquillo, Valerie G Sams, Franco Servadei, Deepak Sharma, Lori Shutter, Philip F Stahel, Fabio S Taccone, Andrew Udy, Tommaso Zoerle, Vanni Agnoletti, Francesca Bravi, Belinda De Simone, Yoram Kluger, Costanza Martino, Ernest E Moore, Massimo Sartelli, Dieter Weber, Chiara Robba
Apr 07, 2023
Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities
Edoardo Picetti, Fausto Catena, Fikri Abu-Zidan, Luca Ansaloni, Rocco A Armonda, Miklosh Bala, Zsolt J Balogh, Alessandro Bertuccio, Walt L Biffl, Pierre Bouzat, Andras Buki, Davide Cerasti, Randall M Chesnut, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Carlo Coniglio, Enrico Fainardi, Deepak Gupta, Jennifer M Gurney, Gregory WJ Hawrylux, Raimund Helbok, Peter JA Hutchinson, Corrado Iaccarino, Angelos Kolias, Ronald W Maier, Matthew J Martin, Geert Meyfroidt, David O Okonkwo, Frank Rasulo, Sandro Rizoli, Andres Rubiano, Juan Sahuquillo, Valerie G Sams, Franco Servadei, Deepak Sharma, Lori Shutter, Philip F Stahel, Fabio S Taccone, Andrew Udy, Tommaso Zoerle, Vanni Agnoletti, Francesca Bravi, Belinda De Simone, Yoram Kluger, Costanza Martino, Ernest E Moore, Massimo Sartelli, Dieter Weber, Chiara Robba
Jan 09, 2023
BACKGROUND: Severe traumatic brain-injured (TBI) patients should be primarily admitted to a hub trauma center (hospital with neurosurgical capabilities) to allow immediate delivery of appropriate care in a specialized...
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Jul 29, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Animals Basic-Leucine Zipper Transcription Factors Cell Line Tumor Cell Proliferation Cell Survival Gene Expression Regulation Neoplastic Humans Immunoconjugates Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Ki-1 Antigen Lymphoma Large-Cell Anaplastic Mice Receptors Interleukin-2 Regulatory Sequences Nucleic Acid Repressor Proteins Signal Transduction Xenograft Model Antitumor Assays
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Oct 24, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Published by: Nature Communications
DEEP MORPHOLOGICAL and SPECTRAL STUDY of the SNR RCW 86 with FERMI-LAT
M Ajello, L Baldini, G Barbiellini, D Bastieri, R Bellazzini, E Bissaldi, ED Bloom, R Bonino, E Bottacini, TJ Brandt, J Bregeon, P Bruel, R Buehler, GA Caliandro, RA Cameron, M Caragiulo, E Cavazzuti, E Charles, A Chekhtman, S Ciprini, J Cohen-Tanugi, B Condon, F Costanza, S Cutini, F D'Ammando, FD Palma, R Desiante, ND Lalla, MD Mauro, LD Venere, PS Drell, G Dubner, D Dumora, L Duvidovich, C Favuzzi, WB Focke, P Fusco, F Gargano, D Gasparrini, E Giacani, N Giglietto, T Glanzman, DA Green, IA Grenier, S Guiriec, E Hays, JW Hewitt, AB Hill, D Horan, T Jogler, G Jóhannesson, I Jung-Richardt, S Kensei, M Kuss, S Larsson, L Latronico, M Lemoine-Goumard, J Li, L Li, F Longo, F Loparco, MN Lovellette, P Lubrano, J Magill, S Maldera, A Manfreda, M Mayer, MN Mazziotta, JE McEnery, PF Michelson, W Mitthumsiri, T Mizuno, ME Monzani, A Morselli, IV Moskalenko, M Negro, E Nuss, M Orienti, E Orlando, JF Ormes, D Paneque, JS Perkins, M Pesce-Rollins, F Piron, G Pivato, TA Porter, S Rainò, R Rando, M Razzano, A Reimer, O Reimer, T Reposeur, J Schmid, A Schulz, C Sgrò, D Simone, EJ Siskind, F Spada, G Spandre, P Spinelli
Jan 28, 2016
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