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Direitos Sociais na Constituição Uma Análise da Constitucionalização dos Direitos Sociais em Portugal, 1975-76
Embora todas as constituições incluam direitos, e muitas delas incluam direitos sociais, a verdade é que algumas são mais generosas do que outras a este respeito. Mas nenhuma se aproxima da Constituição da República Portuguesa...
A Hybrid Binary Bird Swarm Optimization (BSO) and Dragonfly Algorithm (DA) for VM Allocation and Load Balancing in Cloud
The cloud platform is becoming one of the fastest-rising environments in human activities, connecting the whole world in the upcoming decades. The three crucial aspects of cloud computing that enhance the quality of service are...
Published by: IGI Global Scientific Publishing
Organoid Sample Preparation and Extraction for LC-MS Peptidomics.
Emily L Miedzybrodzka, Rachel E Foreman, Sam G Galvin, Pierre Larraufie, Amy L George, Deborah A Goldspink, Frank Reimann, Fiona M Gribble, Richard G Kay
Mar 18, 2021
This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry (LC-MS). Currently, most peptides are quantified by ELISA...
Giovanni Canestrini’s models of Leonardo da Vinci’s friction experiments
IM Hutchings
Feb 16, 2017
Among the exhibits at the 2016 Leonardo da Vinci exhibition at the Science Museum, London, was one that purported to illustrate Leonardo’s experiments on friction. The models involved were the work of Giovanni Canestrini...
Program for the Stage Production of Two One-Act Plays: She Was Only a Farmer's Daughter & Aria Da Capo
Curtain Club
Jan 01, 0001
This two-page program details the Curtain Club of Ursinus College's production of two one-act plays, "She Was Only a Farmer's Daughter" and "Aria Da Capo", held March 19, 1966. It includes information about the casting and...
She Was Only a Farmer's Daughter Aria Da Capo Millard Crosby Edna St. Vincent Millay Curtain Club Ursinus College theater program Theatre and Performance Studies Theatre History
Published by: Ursinus College
Monitoring ash dieback (Hymenoscyphus fraxineus) in British forests using hyperspectral remote sensing
Abstract: Large‐scale dieback of ash trees (Fraxinus spp.) caused by the fungus Hymenoscyphus fraxineus is posing an immense threat to forest health in Europe, requiring effective monitoring at large scales. In this study, a...
Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease.
Vanessa Penna, Niamh Moriarty, Yi Wang, Kevin CL Law, Carlos W Gantner, Richard J Williams, David R Nisbet, Clare L Parish
Apr 25, 2022
Clinical studies have provided evidence for dopamine (DA) cell replacement therapy in Parkinson's Disease. However, grafts derived from foetal tissue or pluripotent stem cells (PSCs) remain heterogeneous, with a high proportion...
Parkinson’s disease SDF1 biomaterials Dopamine Hydrogel Laminin self-assembling peptide Stem Cells stromal cell-derived factor 1 Transplantation Animals Biomimetics Cell Differentiation Chemokine CXCL12 Dopamine Dopaminergic Neurons Extracellular Matrix Fetus Hydrogels Laminin Parkinson Disease Rodentia
Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.
Reinhard Roessler, Sebastien A Smallwood, Jesse V Veenvliet, Petros Pechlivanoglou, Su-Ping Peng, Koushik Chakrabarty, Marian JA Groot-Koerkamp, R Jeroen Pasterkamp, Evelyn Wesseling, Gavin Kelsey, Erik Boddeke, Marten P Smidt, Sjef Copray
Jun 24, 2019
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson's disease. Although iPSC-derived...
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.
Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson's disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the...
Nitrous oxide emissions from sugarcane fields in the Brazilian Cerrado
J Fonseca da Silva, A Moreira de Carvalho, TA Rein, T Rodrigues Coser, W Quadros Ribeiro, D Lino Vieira, DA Coomes
Nov 24, 2017
Brazil meets about 16% of its energy needs with bioethanol and other sugarcane products and leads the world in biofuel energy production. However, there are concerns over the environmental credentials of the sugarcane given the...
Text Chat-Mediated Dynamic Assessment Towards Self-Regulation in Language Learning
Even though the importance of corrective feedback (CF) is widely recognized, there is no agreement on the most effective type of CF for promoting self-regulation. Thus, this study adopts a sociocultural perspective on learning...
Published by: IGI Global Scientific Publishing
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
Effects of quinpirole in the ventral tegmental area on impulsive behaviour during performance on the five-choice serial reaction time task.
Impulsive behaviour on the five-choice serial reaction time task (5CSRTT), a task measuring attention and impulsivity in rodents, is known to depend on dopamine (DA) neurotransmission in the mesolimbic DA pathway. Previous...
Dual mode imaging in mid infrared with thermal signal reconstruction for innovative diagnostics of the "Monocromo" by Leonardo da Vinci.
Dual mode imaging in the mid infrared band, a joint use of thermography and quasi-thermal reflectography, was recently proposed as a full field diagnostic tool in cultural heritage. Here we discuss for the first time, to the...
Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells.
Deborah A Goldspink, Van B Lu, Lawrence J Billing, Pierre Larraufie, Gwen Tolhurst, Fiona M Gribble, Frank Reimann
Jan 31, 2018
OBJECTIVES: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling...
Structure, stoichiometry, and charge transfer in cocrystals of perylene with TCNQ-F<sub>x</sub>
Tommaso Salzillo, Matteo Masino, Gabriele Kociok-Kohn, Daniele Di Nuzzo, Elisabetta Venuti, Raffaele Guido Della Valle, Davide Vanossi, Claudio Fontanesi, Alberto Girlando, Aldo Brillante, Enrico Da Como
May 04, 2016
Semiconductor charge transfer (CT) cocrystals are an emerging class of molecular materials which combines the characteristics of the constituent molecules in order to tune physical properties. Cocrystals can exhibit...
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.
Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson's disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the...
Immunogenicity transplant immune rejection Parkinson’s disease dopaminergic human foetal ventral midbrain
Published by: Neuronal signaling
Models and Tools for Studying Enteroendocrine Cells.
Gut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes....
Structure, stoichiometry, and charge transfer in cocrystals of perylene with TCNQ-F<sub>x</sub>
Tommaso Salzillo, Matteo Masino, Gabriele Kociok-Kohn, Daniele Di Nuzzo, Elisabetta Venuti, Raffaele Guido Della Valle, Davide Vanossi, Claudio Fontanesi, Alberto Girlando, Aldo Brillante, Enrico Da Como
May 04, 2016
Semiconductor charge transfer (CT) cocrystals are an emerging class of molecular materials which combines the characteristics of the constituent molecules in order to tune physical properties. Cocrystals can exhibit...
Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids.
The advent of 3D in vitro organoids that mimic the in vivo tissue architecture and morphogenesis has greatly advanced the ability to study key biological questions in cell and developmental biology. In addition, organoids...
Leonardo da Vinci's studies of friction
IM Hutchings
Apr 28, 2016
Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids.
Emily L Miedzybrodzka, Rachel E Foreman, Van B Lu, Amy L George, Christopher A Smith, Pierre Larraufie, Richard G Kay, Deborah A Goldspink, Frank Reimann, Fiona M Gribble
Oct 15, 2021
Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease.
Paul W Hook, Sarah A McClymont, Gabrielle H Cannon, William D Law, A Jennifer Morton, Loyal A Goff, Andrew S McCallion
Apr 19, 2018
Genetic variation modulating risk of sporadic Parkinson disease (PD) has been primarily explored through genome-wide association studies (GWASs). However, like many other common genetic diseases, the impacted genes remain...
Complexin 1 Parkinson Disease Dopaminergic Neurons Gene Regulatory Networks genome-wide association studies MOUSE single-cell RNA sequencing Substantia Nigra Animals Cell Separation Dopaminergic Neurons Gene Regulatory Networks Genetic Association Studies Genetic Loci Genetic Markers Genome-Wide Association Study Mice Knockout Parkinson Disease Sequence Analysis RNA Single-Cell Analysis Substantia Nigra
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Jo E. Lewis, Emily L. Miedzybrodzka, Rachel E. Foreman, Orla R. M. Woodward, Richard G. Kay, Deborah A. Goldspink, Fiona M. Gribble, Frank Reimann
Apr 27, 2021
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