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DJ-1
Federica De Lazzari, Hiran A Prag, Anja V Gruszczyk, Alexander J Whitworth, Marco Bisaglia
Apr 16, 2021
DJ-1 is a multifaceted protein with pleiotropic functions that has been implicated in multiple diseases, ranging from neurodegeneration to cancer and ischemia-reperfusion injury. Ischemia is a complex pathological state arising...
Sound human, steer clear of jargon, and be prepared.
Kevin McConway and David Spiegelhalter offer tips to statisticians communicating through the media, especially in the time of Covid-19.
The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Mariaelena Repici, Mahdieh Hassanjani, Daniel C Maddison, Pedro Garção, Sara Cimini, Bhavini Patel, Éva M Szegö, Kornelis R Straatman, Kathryn S Lilley, Tiziana Borsello, Tiago F Outeiro, Lia Panman, Flaviano Giorgini
Mar 25, 2019
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson's disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an "upstream" oxidative stress sensor...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Sep 25, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Aug 06, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
Campus Mourns Death of Long-time Employee Sir Lawrence Darby
Winthrop University
Jan 01, 0001
Sir Lawrence Darby, a custodian who worked at the Winthrop Coliseum, passed away on Sunday, Oct. 23, from injuries sustained in a car accident. Darby was very active with the Samaritan's Feet project involving Winthrop's...
Published by: Winthrop University
Communicating health risks in science publications
Abstract
Research that is poorly communicated or presented is as potentially damaging as research that is poorly conducted or fraudulent. Recent examples illustrate how the problem often lies with researchers, not...
Published by: BioMed Central
Risk and uncertainty communication
D Spiegelhalter
Oct 04, 2016
Copyright © 2017 by Annual Reviews. This review briefly examines the vast range of techniques used to communicate risk assessments arising from statistical analysis. After discussing essential psychological and sociological...
Commentary on Piumatti et al. 2018.
David Spiegelhalter
Apr 27, 2018
This is a well-designed study with interesting results. Unfortunately, these results provide no justification for the headline conclusions drawn by the authors, which are in direct contradiction to their own analysis.
Trust in numbers
Summary
Those who value quantitative and scientific evidence are faced with claims both of a reproducibility crisis in scientific publication and of a post-truth society abounding...
D Spiegelhalter
Aug 18, 2017
The Grizzly, February 10, 1984
Perry Romer, Barbara A. Mathers, Richard P. Richter, Brad James, Kurt Richter, Andrea Butler, Timothy Lyden, Michael Walsh, Mark Krauss, John Callahan, Brian E. Kelley
Jan 01, 0001
Guards Receive Training Internships for Credit Alcoholism: Prime Health Problem Businessman to Share Experiences Fish Find a Home China in the 20th Century Television Forum Presented DJ Spotlight on...Ed Johns Two...
Ursinus College Collegeville Pennsylvania newspaper campus security Internships Gerard Fitzpatrick Alcoholism Kenneth H. Williams Warren V. Musser Ed Johns Eugene Miller Charles Gibson Beatles wrestling Basketball gymnastics cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The adverse effects of bisphosphonates in breast cancer
Background: Bisphosphonate drugs can be used to improve the outcomes of women with breast cancer. Whilst many meta-analyses have quantified their potential benefits for patients, attempts at comprehensive quantification of...
Communicating personalized risks from COVID-19
Alexandra L. J. Freeman, John Kerr, Gabriel Recchia, Claudia R. Schneider, Alice C. E. Lawrence, Leila Finikarides, Giulia Luoni, Sarah Dryhurst, David Spiegelhalter
Apr 21, 2021
As increasing amounts of data accumulate on the effects of the novel coronavirus SARS-CoV-2 and the risk factors that lead to poor outcomes, it is possible to produce personalized estimates of the risks faced by groups of people...
How well did experts and laypeople forecast the size of the COVID-19 pandemic?
Throughout the COVID-19 pandemic, social and traditional media have disseminated predictions from experts and nonexperts about its expected magnitude. How accurate were the predictions of 'experts'-individuals holding...
The adverse effects of bisphosphonates in breast cancer
BACKGROUND: Bisphosphonate drugs can be used to improve the outcomes of women with breast cancer. Whilst many meta-analyses have quantified their potential benefits for patients, attempts at comprehensive quantification of...
The effects of communicating uncertainty on public trust in facts and numbers.
Anne Marthe van der Bles, Sander van der Linden, Alexandra L J Freeman, David J Spiegelhalter
Apr 24, 2020
Uncertainty is inherent to our knowledge about the state of the world yet often not communicated alongside scientific facts and numbers. In the "posttruth" era where facts are increasingly contested, a common assumption is that...
Communicating risk in primary care
In 2014, the National Institute for Health Care Excellence (NICE) changed its guidelines for offering statins to patients, reducing the threshold from 20% cardiovascular risk to 10%.1 This ignited a fervent debate about the...
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