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DJ-1
Federica De Lazzari, Hiran A Prag, Anja V Gruszczyk, Alexander J Whitworth, Marco Bisaglia
Apr 16, 2021
DJ-1 is a multifaceted protein with pleiotropic functions that has been implicated in multiple diseases, ranging from neurodegeneration to cancer and ischemia-reperfusion injury. Ischemia is a complex pathological state arising...
Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.
E3 ubiquitin ligase ER-associated degradation HRD1 human cytomegalovirus TMEM129 TRC8 Viral immune evasion Cytomegalovirus Endoplasmic Reticulum Endoplasmic Reticulum-Associated Degradation Gene Expression Regulation Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Integrin alpha Chains Interleukin-2 Receptor beta Subunit Proteolysis RNA-Binding Proteins Receptors Cell Surface Signal Transduction Thrombomodulin Ubiquitin-Protein Ligases Ubiquitination Viral Envelope Proteins Viral Proteins
Interview with Paul Van Buren Hatten - VHP 001
Paul Van Buren Hatten
Jan 01, 0001
In his January 19, 2004 interview with Lee Q. Miller, Paul Van Buren Hatten explains how he entered the service during WWII and became a ball gunner for the Air Force. Hatten recalls basic training, his first mission, and the...
Published by: Winthrop University
The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Mariaelena Repici, Mahdieh Hassanjani, Daniel C Maddison, Pedro Garção, Sara Cimini, Bhavini Patel, Éva M Szegö, Kornelis R Straatman, Kathryn S Lilley, Tiziana Borsello, Tiago F Outeiro, Lia Panman, Flaviano Giorgini
Mar 25, 2019
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson's disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an "upstream" oxidative stress sensor...
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Jan 02, 2019
UNLABELLED: Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation....
E3 ubiquitin ligase ER associated degradation HMGCR RNF145 Cell Biology Cholesterol gp78 human Animals CRISPR-Cas Systems Cholesterol Humans Hydroxymethylglutaryl CoA Reductases Membrane Proteins Mice Proteolysis Receptors Autocrine Motility Factor Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Sep 25, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Aug 06, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.
Dick JH van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke LM Jongsma, Daphne M van Elsland, J Paul Luzio, Jacques JC Neefjes, Paul J Lehner
Sep 22, 2020
Biological Transport CRISPR-Cas Systems Cholesterol Cholesterol LDL Endosomes Fluorescent Dyes Genome Human Guanine Nucleotide Exchange Factors HEK293 Cells HeLa Cells Homeostasis Humans Hydroxymethylglutaryl-CoA Synthase Intracellular Signaling Peptides and Proteins Lysosomes Models Biological Multiprotein Complexes Niemann-Pick C1 Protein Protein Binding Protein Multimerization rab GTP-Binding Proteins rab7 GTP-Binding Proteins
Donald D. Van Slyke, 1916
The Rockefeller University
Jan 01, 0001
Dr. Donald D. Van Slyke. The Present Significance of the Amino-Acids in Physiology and Pathology
Lecture delivered January 15th, 1916
Published by: J.B. Lippincott Company
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner
Nov 03, 2020
Abstract: Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol...
Weitere Beobachtungen Über den Einfluss der Befruchtung und der Zahl der Zellkeme auf die Saurebildung im Ei
Jacques Loeb
Jan 01, 0001
Jacques Loeb. Weitere Beobachtungen Über den Einfluss der Befruchtung und der Zahl der Zellkeme auf die Saurebildung im Ei
Reprinted from Biochem. Z., vol.2 (1906): 34-42
Published by: Rockefeller University
Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.
Jye-Lin Hsu, Dick JH van den Boomen, Peter Tomasec, Michael P Weekes, Robin Antrobus, Richard J Stanton, Eva Ruckova, Daniel Sugrue, Gavin S Wilkie, Andrew J Davison, Gavin WG Wilkinson, Paul J Lehner
Jun 02, 2015
Cell Line Tumor Cell Membrane Chromatography High Pressure Liquid Cytomegalovirus Flow Cytometry Humans Immune Evasion Immunoblotting Immunoprecipitation Killer Cells Natural Lymphocyte Activation Mass Spectrometry Membrane Glycoproteins Membrane Proteins Proteomics RNA Small Interfering Transduction Genetic Viral Envelope Proteins Viral Proteins
Defect passivation of transition metal dichalcogenides via a charge transfer van der Waals interface.
Jun Hong Park, Atresh Sanne, Yuzheng Guo, Matin Amani, Kehao Zhang, Hema CP Movva, Joshua A Robinson, Ali Javey, John Robertson, Sanjay K Banerjee, Andrew C Kummel
Apr 13, 2018
Integration of transition metal dichalcogenides (TMDs) into next-generation semiconductor platforms has been limited due to a lack of effective passivation techniques for defects in TMDs. The formation of an organic-inorganic...
The draft genome of Ditylenchus dipsaci.
Benjamin Mimee, Etienne Lord, Pierre-Yves Véronneau, Rick Masonbrink, Qing Yu, Sebastian Eves-van den Akker
Jul 16, 2020
Ditylenchus dipsaci is a devastating pest to many crops worldwide. We present the first genome sequence for this species, produced with PacBio sequencing and assembled with CANU. Ditylenchus dipsaci is a devastating pest to many...
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Sandra Stefanovic-Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick JH van den Boomen, Paul J Lehner, James A Nathan
May 02, 2018
Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human...
Heterostructures formed through abraded van der Waals materials
Darren Nutting, Jorlandio F. Felix, Evan Tillotson, Dong-Wook Shin, Adolfo De Sanctis, Hong Chang, Nick Cole, Saverio Russo, Adam Woodgate, Ioannis Leontis, Henry A. Fernández, Monica F. Craciun, Sarah J. Haigh, Freddie Withers
Jun 16, 2020
Abstract: To fully exploit van der Waals materials and their vertically stacked heterostructures, new mass-scalable production routes which are low cost but preserve the high electronic and optical quality of the single crystals...
Heterostructures formed through abraded van der Waals materials
Darren Nutting, Jorlandio F. Felix, Evan Tillotson, Dong-Wook Shin, Adolfo De Sanctis, Hong Chang, Nick Cole, Saverio Russo, Adam Woodgate, Ioannis Leontis, Henry A. Fernández, Monica F. Craciun, Sarah J. Haigh, Freddie Withers
Jun 17, 2021
Abstract: To fully exploit van der Waals materials and their vertically stacked heterostructures, new mass-scalable production routes which are low cost but preserve the high electronic and optical quality of the single crystals...
Heterostructures formed through abraded van der Waals materials.
Darren Nutting, Jorlandio F Felix, Evan Tillotson, Dong-Wook Shin, Adolfo De Sanctis, Hong Chang, Nick Cole, Saverio Russo, Adam Woodgate, Ioannis Leontis, Henry A Fernández, Monica F Craciun, Sarah J Haigh, Freddie Withers
Aug 07, 2020
To fully exploit van der Waals materials and their vertically stacked heterostructures, new mass-scalable production routes which are low cost but preserve the high electronic and optical quality of the single crystals are...
Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing
Axel T Brunger, Debanu Das, Ashley M Deacon, Joanna Grant, Thomas C Terwilliger, Randy J Read, Paul D Adams, Michael Levitt, Gunnar F Schröder
May 11, 2020
Phasing by molecular replacement remains difficult for targets that are far from the search model or in situations where the crystal diffracts only weakly or to low resolution. Here, the process of determining and refining the...
Cindy Van Buren Appointed to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Van Buren's appointment is effective immediately, and the Prosperity resident will join the Board of Trustees at its next meeting on Aug. 25. She has worked at the S.C. State Department of Education since April 2013 and is...
Published by: Winthrop University
Negative Differential Resistance in van der Waals Heterostructures Due to Moiré-Induced Spectral Reconstruction
Formation of moiré superlattices is common in van der Waals heterostructures as a result of the mismatch between lattice constants and misalignment of crystallographic directions of the constituent two-dimensional crystals....
Critical Response of a Quantum van der Pol Oscillator.
Classical dynamical systems close to a critical point are known to act as efficient sensors due to a strongly nonlinear response. We explore such systems in the quantum regime by modeling a quantum version of a driven van der...
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