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Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
JT Powell, MJ Sweeting, P Ulug, JD Blankensteijn, FA Lederle, J-P Becquemin, RM Greenhalgh, DREAM, OVER and ACE Trialists EVAR-1
Nov 13, 2017
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
Jun 08, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
May 23, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Published by: Scientific reports
Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh, EVAR Trial Investigators
Dec 06, 2017
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or...
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.
M Loredana Marcovecchio, Scott T Chiesa, Simon Bond, Denis Daneman, Sarah Dawson, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, R Neil Dalton, John Deanfield, David B Dunger, AdDIT Study Group
Jul 10, 2017
BACKGROUND: Among adolescents with type 1 diabetes, rapid increases in albumin excretion during puberty precede the development of microalbuminuria and macroalbuminuria, long-term risk factors for renal and cardiovascular...
The Adaptive designs CONSORT Extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jul 01, 2020
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
The adaptive designs CONSORT extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jun 17, 2021
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
DREAM Educational Management and Leadership
Phil Quirke
Feb 19, 2024
This chapter describes the DREAM educational management and leadership approach, which the author has been implementing, researching, and developing for two decades. The DREAM acronym is based on ten principles inspired by...
Educational Technologies Education Educational Technologies Computer Science and Information Technology Library and Information Science
Published by: IGI Global Scientific Publishing
DREAM represses distinct targets by cooperating with different THAP domain proteins.
Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Yan Dong, Jane Murphy, Andrea Frapporti, Julie Ahringer
Sep 27, 2021
The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and other genes, but its mechanism of action is unclear. Here, we demonstrate that two...
dream H2A.Z H3K9me2 THAP lin-15B lin-35 lin-36 quiescence retinoblastoma TRANSCRIPTIONAL REPRESSION Animals Animals Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Proteins DNA Methylation E2F Transcription Factors Gene Expression Regulation Histones Promoter Regions Genetic Protein Binding Protein Interaction Domains and Motifs Retinoblastoma Protein Transcription Factors
Inability to get up after falling, subsequent time on floor, and summoning help
OBJECTIVES: To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to explore their use of call alarm systems in these circumstances....
The adaptive designs CONSORT extension (ACE) statement
Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A. Julious, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Jon P. Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott, Yuki Ando, Daniel Hind, Douglas G. Altman, Munyaradzi Dimairo, Jon Nicholl, William J. Meurer, Christopher Cates, Matthew Sydes, Yannis Jemiai, Deborah Ashby, Christina Yap, Frank Waldron-Lynch, James Roger, Joan Marsh, Olivier Collignon, David J. Lawrence, Catey Bunce, Tom Parke, Gus Gazzard, Sally Hopewell
Jun 17, 2020
Abstract: Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The...
Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1)
Comprehensive review on some food-derived bioactive peptides with anti-hypertension therapeutic potential for angiotensin-converting enzyme (ACE) inhibition
Angiotensin-converting enzyme (ACE) inhibitory peptides have lately attracted interest since functional foods that help maintain homeostatic regulations have been developed. Rarely discussed are the intrinsic ACE-peptide...
Comprehensive review on some food-derived bioactive peptides with anti-hypertension therapeutic potential for angiotensin-converting enzyme (ACE) inhibition
Angiotensin-converting enzyme (ACE) inhibitory peptides have lately attracted interest since functional foods that help maintain homeostatic regulations have been developed. Rarely discussed are the intrinsic ACE-peptide...
Falls in advanced old age
Jane Fleming, Fiona E Matthews, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 16, 2011
BACKGROUND: The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is...
The Fornaldarsaga in a Dream
JYH Hui
Feb 09, 2017
Stjörnu-Odda draumr (‘Star-Oddi’s dream’) is a relatively little-known
Íslendingaþáttr (‘tale of Icelanders’) which dates from the latefourteenth century at the latest but which no longer survives in anymanuscripts predating...
Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme
Kate M. Larmuth, Geoffrey Masuyer, Ross G. Douglas, Sylva L. Schwager, K. Ravi Acharya, Edward D. Sturrock
Mar 01, 2016
Angiotensin-1-converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities. Here we report kinetic parameters of five different forms of human...
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
Participant and public involvement in refining a peer-volunteering active aging intervention
Janet Withall, Janice L Thompson, Kenneth R Fox, Mark Davis, Selena Gray, Jolanthe De Koning, Liz Lloyd, Graham Parkhurst, Afroditi Stathi
Dec 06, 2016
Background: Evidence for the health benefits of a physically active lifestyle among older adults is strong, yet only a small proportion of older people meet physical activity recommendations. A synthesis of evidence identified...
Program for the Stage Production A Midsummer Night's Dream
ProTheatre Club
Jan 01, 0001
This four-page program details the ProTheatre of Ursinus College's production of "A Midsummer Night's Dream", held March 26 through 28 and April 2 through 4, 1981, in the Ritter Center. It includes information regarding the cast...
A Midsummer Night's Dream William Shakespeare ProTheatre Ursinus College theater program Ritter Center Theatre and Performance Studies Theatre History
Published by: Ursinus College
Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme
Kate M. Larmuth, Geoffrey Masuyer, Ross G. Douglas, Sylva L. Schwager, K. Ravi Acharya, Edward D. Sturrock
Mar 01, 2016
Angiotensin-1-converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities. Here we report kinetic parameters of five different forms of human...
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