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Results: 22
Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias.
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan-Henning Klusmann, Joost HA Martens, Alexandre Faille, Alan J Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Jul 22, 2022
BACKGROUND: Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein-driven paediatric cancer, with MLL (KMT2A)-fusions present in most cases. Direct...
Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan‐Henning Klusmann, Joost HA Martens, Alexandre Faille, Alan J Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Jun 29, 2022
Abstract: Background: Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases....
Stacking-dependent superstructures at stepped armchair interfaces of bilayer/trilayer graphene
We present the first study of quantum interference patterns at a bilayer-trilayer armchair interface, for different stacking sequences. Visualization using scanning tunneling microscopy and theoretical calculations provide...
Stacking-dependent superstructures at stepped armchair interfaces of bilayer/trilayer graphene
We present the first study of quantum interference patterns at a bilayer-trilayer armchair interface, for different stacking sequences. Visualization using scanning tunneling microscopy and theoretical calculations provide...
What Does It Take to Search Organized? The Cognitive Correlates of Search Organization During Cancellation After Stroke
OBJECTIVES: Stroke could lead to deficits in organization of visual search. Cancellation tests are frequently used in standard neuropsychological assessment and appear suitable to measure search organization. The current aim was...
What Does It Take to Search Organized? The Cognitive Correlates of Search Organization During Cancellation After Stroke
OBJECTIVES: Stroke could lead to deficits in organization of visual search. Cancellation tests are frequently used in standard neuropsychological assessment and appear suitable to measure search organization. The current aim was...
Legacy ExtraGalactic UV Survey with The $\textit{Hubble Space Telescope}$
A Adamo, JE Ryon, M Messa, H Kim, K Grasha, DO Cook, D Calzetti, JC Lee, BC Whitmore, BG Elmegreen, L Ubeda, LJ Smith, SN Bright, A Runnholm, JE Andrews, M Fumagalli, DA Gouliermis, L Kahre, P Nair, D Thilker, R Walterbos, A Wofford, A Aloisi, G Ashworth, TM Brown, R Chandar, C Christian, M Cignoni, GC Clayton, DA Dale, SED Mink, C Dobbs, DM Elmegreen, AS Evans, JSG III, EK Grebel, A Herrero, DA Hunter, KE Johnson, RC Kennicutt, MR Krumholz, D Lennon, K Levay, C Martin, A Nota, G Ostlin, A Pellerin, J Prieto, MW Regan, E Sabbi, E Sacchi, D Schaerer, DSF Shabani, M Tosi, SDV Dyk, E Zackrisson
Jun 28, 2017
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention
Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J. A. Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G. Kolias, Andres M. Rubiano, Alexis J. Joannides, Hamisi K. Shabani
May 20, 2021
Abstract: Background: Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs). Neurotrauma and...
Draft genome sequence of a multidrug-resistant caprine isolate of Staphylococcus cohnii subsp. urealyticus from Tanzania encoding ermB, tet(K), dfrG, fusF and fosD.
Jeremiah Seni, Stephen E Mshana, Felician Msigwa, Shabani Iddi, Humphrey Mazigo, Julian Parkhill, Mark A Holmes, Gavin K Paterson
Aug 02, 2019
OBJECTIVES: Coagulase-negative staphylococci such as Staphylococcus cohnii are opportunistic pathogens of humans and animals. A multidrug-resistant isolate of S. cohnii subsp. urealyticus (073AN) was isolated from the nasal...
Using Rubrics for Language Assessment
Laura Mendoza
Aug 14, 2023
The use of rubrics for classroom assessment has been evolving rapidly during the last decades. Unfortunately, because rubrics across language classrooms are only sometimes standardized, some may provide a non-friendly language...
classroom management Education Learning Assessment and Measurement Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention
Santhani M Selveindran, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J A Hutchinson, Carol Brayne, Christine Hill, Angelos Kolias, Alexis J Joannides, Franco Servadei, Andres M Rubiano, Hamisi K Shabani
Dec 15, 2019
INTRODUCTION:Neurotrauma is an important global health problem. This 'silent epidemic' is a major cause of death and disability in adolescents and young adults, with significant societal and economic impacts. Globally, the...
Mass spectrometry for fragment screening.
Fragment-based approaches in chemical biology and drug discovery have been widely adopted worldwide in both academia and industry. Fragment hits tend to interact weakly with their targets, necessitating the use of sensitive...
Fragment-based drug discovery ligand-observed mass spectrometry native mass spectrometry Calorimetry Combinatorial Chemistry Techniques Crystallography X-Ray Drug Design Drug Discovery Fluorometry High-Throughput Screening Assays Humans Ligands Magnetic Resonance Spectroscopy Mass Spectrometry Protein Binding Proteins Small Molecule Libraries Structure-Activity Relationship
The Hierarchical Distribution of the Young Stellar Clusters in Six Local Star-forming Galaxies
K Grasha, D Calzetti, A Adamo, H Kim, BG Elmegreen, DA Gouliermis, DA Dale, M Fumagalli, EK Grebel, KE Johnson, L Kahre, RC Kennicutt, M Messa, A Pellerin, JE Ryon, LJ Smith, F Shabani, D Thilker, L Ubeda
Aug 11, 2017
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention
Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter JA Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G Kolias, Andres M Rubiano, Alexis J Joannides, Hamisi K Shabani
Apr 09, 2020
BACKGROUND: Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs). Neurotrauma and RTCs are...
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention
Santhani M Selveindran, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter JA Hutchinson, Carol Brayne, Christine Hill, Angelos Kolias, Alexis J Joannides, Franco Servadei, Andres M Rubiano, Hamisi K Shabani
Sep 10, 2020
INTRODUCTION: Neurotrauma is an important global health problem. This 'silent epidemic' is a major cause of death and disability in adolescents and young adults, with significant societal and economic impacts. Globally, the...
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention
Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J. A. Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G. Kolias, Andres M. Rubiano, Alexis J. Joannides, Hamisi K. Shabani
Jun 06, 2020
Abstract: Background: Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs). Neurotrauma and...
Hierarchical star formation across the grand-design spiral NGC 1566
DA Gouliermis, BG Elmegreen, DM Elmegreen, D Calzetti, M Cignoni, JS Gallagher, RC Kennicutt, RS Klessen, E Sabbi, D Thilker, L Ubeda, A Aloisi, A Adamo, DO Cook, D Dale, K Grasha, EK Grebel, KE Johnson, E Sacchi, F Shabani, LJ Smith, A Wofford
May 05, 2017
Public involvement in the governance of population-level biomedical research
Sonja Erikainen, Phoebe Friesen, Leah Rand, Karin Jongsma, Michael Dunn, Annie Sorbie, Matthew McCoy, Jessica Bell, Michael Burgess, Haidan Chen, Vicky Chico, Sarah Cunningham-Burley, Julie Darbyshire, Rebecca Dawson, Andrew Evans, Nick Fahy, Teresa Finlay, Lucy Frith, Aaron Goldenberg, Lisa Hinton, Nils Hoppe, Nigel Hughes, Barbara Koenig, Sapfo Lignou, Michelle McGowan, Michael Parker, Barbara Prainsack, Mahsa Shabani, Ciara Staunton, Rachel Thompson, Kinga Varnai, Effy Vayena, Oli Williams, Max Williamson, Sarah Chan, Mark Sheehan
Dec 18, 2020
Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these...
Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury
Peter J Hutchinson, Angelos G Kolias, Tamara Tajsic, Amos Adeleye, Abenezer Tirsit Aklilu, Tedy Apriawan, Abdul Hafid Bajamal, Ernest J Barthélemy, B Indira Devi, Dhananjaya Bhat, Diederik Bulters, Randall Chesnut, Giuseppe Citerio, D Jamie Cooper, Marek Czosnyka, Idara Edem, Nasser MF El-Ghandour, Anthony Figaji, Kostas N Fountas, Clare Gallagher, Gregory WJ Hawryluk, Corrado Iaccarino, Mathew Joseph, Tariq Khan, Tsegazeab Laeke, Oleg Levchenko, Baiyun Liu, Weiming Liu, Andrew Maas, Geoffrey T Manley, Paul Manson, Anna T Mazzeo, David K Menon, Daniel B Michael, Susanne Muehlschlegel, David O Okonkwo, Kee B Park, Jeffrey V Rosenfeld, Gail Rosseau, Andres M Rubiano, Hamisi K Shabani, Nino Stocchetti, Shelly D Timmons, Ivan Timofeev, Chris Uff, Jamie S Ullman, Alex Valadka, Vicknes Waran, Adam Wells, Mark H Wilson, Franco Servadei
May 07, 2019
Management and outcomes following emergency surgery for traumatic brain injury – a multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study)
David Clark, Alexis Joannides, Omar Ibrahim Abdallah, Amos Olufemi Adeleye, Abdul Hafid Bajamal, Tom Bashford, Arnold Bhebhe, Hagos Biluts, Natalia Budohoska, Karol Budohoski, Iype Cherian, Niklas Marklund, Rocio Fernandez Mendez, Tony Figaji, Deepak Kumar Gupta, Corrado Iaccarino, Ali Ilunga, Mathew Joseph, Tariq Khan, Tsegazeab Laeke, Vicknes Waran, Kee Park, Gail Rosseau, Andres Rubiano, Youssuf Saleh, Hamisi K Shabani, Brandon Smith, Kachinga Sichizya, Manoj Tewari, Abenezer Tirsit, Myat Thu, Manjul Tripathi, Rikin Trivedi, Sofia Villar, Indira Devi Bhagavatula, Franco Servadei, David Menon, Angelos Kolias, Peter Hutchinson
Mar 07, 2020
Management and outcomes following emergency surgery for traumatic brain injury - A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study).
David Clark, Alexis Joannides, Omar Ibrahim Abdallah, Amos Olufemi Adeleye, Abdul Hafid Bajamal, Tom Bashford, Arnold Bhebhe, Hagos Biluts, Natalia Budohoska, Karol Budohoski, Iype Cherian, Niklas Marklund, Rocio Fernandez Mendez, Tony Figaji, Deepak Kumar Gupta, Corrado Iaccarino, Ali Ilunga, Mathew Joseph, Tariq Khan, Tsegazeab Laeke, Vicknes Waran, Kee Park, Gail Rosseau, Andres Rubiano, Youssuf Saleh, Hamisi K Shabani, Brandon Smith, Kachinga Sichizya, Manoj Tewari, Abenezer Tirsit, Myat Thu, Manjul Tripathi, Rikin Trivedi, Sofia Villar, Indira Devi Bhagavatula, Franco Servadei, David Menon, Angelos Kolias, Peter Hutchinson
Apr 30, 2020
Introduction:Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. Despite this, considerable...
Published by: International journal of surgery protocols
Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury
Peter J. Hutchinson, Angelos G. Kolias, Tamara Tajsic, Amos Adeleye, Abenezer Tirsit Aklilu, Tedy Apriawan, Abdul Hafid Bajamal, Ernest J. Barthélemy, B. Indira Devi, Dhananjaya Bhat, Diederik Bulters, Randall Chesnut, Giuseppe Citerio, D. Jamie Cooper, Marek Czosnyka, Idara Edem, Nasser M.F. El-Ghandour, Anthony Figaji, Kostas N. Fountas, Clare Gallagher, Gregory W.J. Hawryluk, Corrado Iaccarino, Mathew Joseph, Tariq Khan, Tsegazeab Laeke, Oleg Levchenko, Baiyun Liu, Weiming Liu, Andrew Maas, Geoffrey T. Manley, Paul Manson, Anna T. Mazzeo, David K. Menon, Daniel B. Michael, Susanne Muehlschlegel, David O. Okonkwo, Kee B. Park, Jeffrey V. Rosenfeld, Gail Rosseau, Andres M. Rubiano, Hamisi K. Shabani, Nino Stocchetti, Shelly D. Timmons, Ivan Timofeev, Chris Uff, Jamie S. Ullman, Alex Valadka, Vicknes Waran, Adam Wells, Mark H. Wilson, Franco Servadei
Jun 06, 2020
Abstract: Background: Two randomised trials assessing the effectiveness of decompressive craniectomy (DC) following traumatic brain injury (TBI) were published in recent years: DECRA in 2011 and RESCUEicp in 2016. As the results...