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Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results inthe...
The materiality of precarity
Analysis of precarity has offered a critique of labour market experiences and politically induced conditions of work, housing, migration, or essential services. This paper develops an infrastructural politics of precarity by...
Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia
The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact...
APP ER stress Autophagy insulin degrading enzyme Microglia β-amyloid /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1314 name=Physiology /dk/atira/pure/subjectarea/asjc/2800/2805 name=Cognitive Neuroscience /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results inthe...
Response to Correspondence from Kolstoe and colleagues concerning our paper entitled, Research approvals iceberg
In their letter to the Editor in this issue, Kolstoe and Carpenter challenge a core aspect of our recently published case study of research approvals [BMC Medical Ethics 20:7] by arguing that we conflate research ethics with...
Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia
The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact...
APP ER stress Autophagy insulin degrading enzyme Microglia β-amyloid /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1314 name=Physiology /dk/atira/pure/subjectarea/asjc/2800/2805 name=Cognitive Neuroscience /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Microglia and the aging brain
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions...
Using deep convolutional neural networks to forecast spatial patterns of Amazonian deforestation
Abstract: Tropical forests are subject to diverse deforestation pressures while their conservation is essential to achieve global climate goals. Predicting the location of deforestation is challenging due to the complexity of...
Research approvals iceberg
BACKGROUND: The red tape and delays around research ethics and governance approvals frequently frustrate researchers yet, as the lesser of two evils, are largely accepted as unavoidable. Here we quantify aspects of the research...
Bioethics [MeSH] Biomedical ethics Ethical review [MeSH] ethics Ethics Committees Evaluation studies [MeSH] IRB Institutional review boards Research [MeSH] clinical governance Cooperative Behavior England Ethical Review Ethics Committees research ethics research Government Agencies Humans Interviews as Topic Research Personnel Surveys and Questionnaires
Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts
Palliative Care public health ethics Altruism Betacoronavirus Bioethical Issues Bioethics covid-19 Coronavirus Infections Critical Care Decision Making Delivery of Health Care Disaster Planning Emergencies ethics clinical Global Health Health Care Rationing Health equity Health Resources Humans Palliative Care Pandemics Pneumonia Viral Practice Guidelines as Topic SARS-CoV-2 Socioeconomic Factors Stress Psychological Terminal Care
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.
Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions...
Health-related quality of life, palliative care needs and 12-month survival among patients with end stage renal disease in Uganda
BACKGROUND: The prevalence of chronic kidney disease is on the rise globally and in sub-Saharan Africa. Due to its "silent" nature, many patients often present with advanced disease. At this point options for care are often...
Chronic [MeSH] Developing countries [MeSH] Kidney Failure LMIC low and middle income countries mixed methods Palliative care [MeSH] renal Dialysis [MeSH] Quality of life [MeSH] Resource limited setting Conservative Treatment Humans Kidney Failure Chronic Longitudinal Studies Needs Assessment Palliative Care Pilot Projects qualitative research Quality of life Renal Dialysis Surveys and Questionnaires Survival Rate Uganda
Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.
Charlotte J Houldcroft, Velislava Petrova, Jimmy Z Liu, Dan Frampton, Carl A Anderson, Astrid Gall, Paul Kellam
Nov 30, 2018
Lymphoblastoid cell lines (LCLs) are commonly used in molecular genetics, supplying DNA for the HapMap and 1000 Genomes Projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics...
Illness-related suffering and need for palliative care in Rohingya refugees and caregivers in Bangladesh
Megan Doherty, Liam Power, Mila Petrova, Scott Gunn, Richard Powell, Rachel Coghlan, Liz Grant, Brett Sutton, Farzana Khan
Apr 03, 2020
BACKGROUND:Despite recognition that palliative care is an essential component of any humanitarian response, serious illness-related suffering continues to be pervasive in these settings. There is very limited evidence about the...
Published by: PLoS Medicine
Comparison of the health-related quality of life of end stage kidney disease patients on hemodialysis and non-hemodialysis management in Uganda.
Peace Bagasha, Elizabeth Namukwaya, Mhoira Leng, Robert Kalyesubula, Edrisa Mutebi, Ronald Naitala, Elly Katabira, Mila Petrova
Apr 02, 2021
BACKGROUND: Health-related quality of life is recognized as a key outcome in chronic disease management, including kidney disease. With no national healthcare coverage for hemodialysis, Ugandan patients struggle to pay for their...
Palliative care in humanitarian crises
More than 128·6 million people across 33 countries require life-saving humanitarian assistance, 92·8 million of whom are particularly vulnerable. Palliative care, however, has been omitted from efforts to tackle humanitarian...
Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
Hiroaki Koseki, Matteo Donegá, Brian YH Lam, Veselina Petrova, Susan van Erp, Giles SH Yeo, Jessica CF Kwok, Charles ffrench-Constant, Richard Eva, James W Fawcett
May 09, 2018
Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone...
Asynchrony between virus diversity and antibody selection limits influenza virus evolution.
Dylan H Morris, Velislava N Petrova, Fernando W Rossine, Edyth Parker, Bryan T Grenfell, Richard A Neher, Simon A Levin, Colin A Russell
Dec 22, 2020
Influenza virus antibody-mediated selection cross scale evolutionary dynamics evolutionary biology infectious disease microbiology Virus Antibodies Neutralizing Antibodies Viral Biological Evolution genetic variation Humans Influenza A virus H3N2 Subtype Influenza A virus Influenza Human Models Statistical selection Genetic Virion
Structure-activity relationships of rationally designed AMACR 1A inhibitors
Maksims Jevglevskis, Guat Ling Lee, Amit Nathubhai, Yoana Petrova, Tony James, Michael Threadgill, Timothy Woodman, Matthew Lloyd
Sep 01, 2018
α-Methylacyl-CoA racemase (AMACR; P504S) is a promising novel drug target for prostate and other cancers. Assaying enzyme activity is difficult due to the reversibility of the ‘racemisation’ reaction and the difficulties in...
Drug lipophilicity Enzyme Inhibitors Rational drug design structure-activity relationships α-Methylacyl-CoA racemase (AMACR P504S) /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
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