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Targeting macrophage- and intestinal epithelial cell-specific microRNAs against norovirus restricts replication in vivo.
Until recently, our understanding of the cellular tropism of human norovirus (HuNoV), a major cause of viral gastroenteritis, has been limited. Immune cells and intestinal epithelial cells (IECs) have been proposed as targets of...
Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein.
Giulia Gallo, Carina Conceicao, Christina Tsirigoti, Brian Willett, Stephen C Graham, Dalan Bailey
Mar 09, 2021
The enveloped morbilliviruses utilise conserved proteinaceous receptors to enter host cells: SLAMF1 or Nectin-4. Receptor binding is initiated by the viral attachment protein Haemagglutinin (H), with the viral Fusion protein (F)...
directed evolution epPCR morbillivirus peste des petits ruminants virus viral entry Viral evolution Animals Cell Adhesion Molecules Hemagglutinins Viral Host Microbial Interactions Membrane Fusion Peste-des-petits-ruminants virus Polymerase Chain Reaction Sheep Signaling Lymphocytic Activation Molecule Family Member 1 Viral Fusion Proteins
Usage and User Experience in an Academic Law Library
Abstract This article, written by Josephine Bailey and Kate Faulkner, discusses the collection of library usage data at the Squire Law Library, an academic law library embedded in the Faculty of...
Pathology caused by persistent murine norovirus infection.
Amita Shortland, James Chettle, Joy Archer, Kathryn Wood, Dalan Bailey, Ian Goodfellow, Barbara A Blacklaws, Jonathan L Heeney
Mar 13, 2020
Subclinical infection of murine norovirus (MNV) was detected in a mixed breeding group of WT and Stat1(-/-) mice with no outward evidence of morbidity or mortality. Investigations revealed the presence of an attenuated MNV...
The murine norovirus core subgenomic RNA promoter consists of a stable stem-loop that can direct accurate initiation of RNA synthesis.
The Grizzly, January 27, 1989
Kevin Murphy, Michelle L. Grande, Todd Koser, Richard P. Richter, Coleen Casciano, Bob Gonnella, Matt Weintraub, Bridget Algeo, Lora L. Hart, Sharon Festa, Judd Woytek, Lenore Bailey, Gabriel Laboca, Steven Grim, Katherine Grim
Jan 01, 0001
Constructium Ursini Ad Hoc Hoists Honor New GPA: 2.25 or Dive! Letter: Green Shirt Makes Reed Red Fair Not Just for Freshmen Security Shacks in Reimert Beverly Oehlert Named to Pottstown Board of Directors Final Red and...
Ursinus College Collegeville Pennsylvania newspaper Wismer dining hall Jonny King Quintet Robin Greenstein campus security George Bush board of directors Llewellyn F. Dryfoos David J. Knauer field hockey Adele Boyd Swimming Basketball Beverly Oehlert Pottstown Memorial Medical Center Reimert Hall Red and Gold day activities fair grading system Olin Hall construction honor code cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Seasoned Antisemitism: Cannibalism in The Destruction of Jerusalem
Bailey Ludwig
Jan 01, 0001
My project examines an episode of maternal cannibalism within the medieval poem The Destruction of Jerusalem. Several variations of the story of the 70 AD Roman siege of Jerusalem that include this particular episode exist; the...
Destruction of Jerusalem cannibalism Eusebius antisemitism La Vengeance de Nostre-Seigneur the siege of Jerusalem transubstantiation Arts and Humanities English Language and Literature Jewish Studies Medieval Studies
Published by: Ursinus College
Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients.
Diego Cantoni, Martin Mayora-Neto, Nazia Thakur, Ahmed ME Elrefaey, Joseph Newman, Sneha Vishwanath, Angalee Nadesalingam, Andrew Chan, Peter Smith, Javier Castillo-Olivares, Helen Baxendale, Bryan Charleston, Jonathan Heeney, Dalan Bailey, Nigel Temperton
May 09, 2022
RaTG13 is a close relative of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, sharing 96% sequence similarity at the genome-wide level. The spike receptor binding domain (RBD) of RaTG13 contains a number of amino...
A Sample of Understudied Works in Aberdeen MS 123
Bailey Ludwig
Jan 01, 0001
This project examines and transcribes various understudied texts from the University of Aberdeen's MS 123 in order to create a more complete picture of this manuscript. Chapter one looks at the "Sultan Letters" and "List of...
aberdeen ms 123 middle english miscellany crusades Medicine Gender Arts and Humanities English Language and Literature Medieval Studies
Published by: Ursinus College
An entropic safety catch controls hepatitis C virus entry and antibody resistance.
Lenka Stejskal, Mphatso D Kalemera, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, christopher Illingworth, Adrian J Shepherd, Joe Grove
Jul 28, 2022
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2...
Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients.
Modeling human embryo development with embryonic and extra-embryonic stem cells
Early human post-implantation development involves extensive growth combined with a series of complex morphogenetic events. The lack of precise spatial and temporal control over these processes leads to pregnancy loss. Given the...
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Alyssa Silva-Cayetano, William S Foster, Silvia Innocentin, Sandra Belij-Rammerstorfer, Alexandra J Spencer, Oliver T Burton, Sigrid Fra-Bidó, Jia Le Lee, Nazia Thakur, Carina Conceicao, Daniel Wright, Jordan Barrett, Nicola Evans-Bailey, Carly Noble, Dalan Bailey, Adrian Liston, Sarah C Gilbert, Teresa Lambe, Michelle A Linterman
Feb 19, 2021
BACKGROUND: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by...
An entropic safety catch controls hepatitis C virus entry and antibody resistance.
Lenka Stejskal, Mphatso D Kalemera, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, Christopher JR Illingworth, Adrian J Shepherd, Joe Grove
Aug 07, 2022
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2...
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester.
While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but...
Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential.
Nurshariza Abdullah, James T Kelly, Stephen C Graham, Jamie Birch, Daniel Gonçalves-Carneiro, Tim Mitchell, Robin N Thompson, Katrina A Lythgoe, Nicola Logan, Margaret J Hosie, Vassiliy N Bavro, Brian J Willett, Michael P Heaton, Dalan Bailey
Nov 20, 2018
Morbilliviruses infect a broad range of mammalian hosts, including ruminants, carnivores, and humans. The recent eradication of rinderpest virus (RPV) and the active campaigns for eradication of the human-specific measles virus...
PPRV host range Measles morbillivirus paramyxovirus Zoonoses Amino Acid Sequence Animals Antibodies Viral Chlorocebus aethiops Glycoproteins Humans Models Theoretical Mutagenesis Site-Directed Mutation Peste-des-Petits-Ruminants Peste-des-petits-ruminants virus Protein Conformation Sequence Homology Sheep Signaling Lymphocytic Activation Molecule Family Member 1 Vero Cells Virus Replication
Science Educators Will Be on Campus This Weekend Discussing Teaching Strategies
Winthrop University
Jan 01, 0001
Called "Connecting Core Concepts and Best Teaching Practices in Biochemistry and Molecular Biology," the workshop will help attendees develop new assessment tools for core concepts in biochemistry and molecular biology. ...
Published by: Winthrop University
Reconstructing aspects of human embryogenesis with pluripotent stem cells
Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Sep 21, 2021
Abstract: Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins.
Carina Conceicao, Nazia Thakur, Stacey Human, James T Kelly, Leanne Logan, Dagmara Bialy, Sushant Bhat, Phoebe Stevenson-Leggett, Adrian K Zagrajek, Philippa Hollinghurst, Michal Varga, Christina Tsirigoti, Matthew Tully, Chris Chiu, Katy Moffat, Adrian Paul Silesian, John A Hammond, Helena J Maier, Erica Bickerton, Holly Shelton, Isabelle Dietrich, Stephen C Graham, Dalan Bailey
Feb 05, 2021
SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to...
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey A T Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Oct 23, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Pluripotent Stem Cells Blastocyst Humans Adaptor Proteins Signal Transducing Cell Culture Techniques Sequence Analysis RNA Gene Expression Cell Lineage Embryonic Development Models Biological GATA3 Transcription Factor Embryo Mammalian Phospholipase C beta SOXB1 Transcription Factors SOXF Transcription Factors Single-Cell Analysis Biomarkers
Published by: Nature Communications
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey AT Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Aug 26, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Adaptor Proteins Signal Transducing Biomarkers Blastocyst Cell Culture Techniques Cell Lineage Embryo Mammalian Embryonic Development GATA3 Transcription Factor Gene Expression Humans Models Biological Phospholipase C beta Pluripotent Stem Cells SOXB1 Transcription Factors SOXF Transcription Factors Sequence Analysis RNA Single-Cell Analysis
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
Bo Meng, Steven A Kemp, Guido Papa, Rawlings Datir, Isabella ATM Ferreira, Sara Marelli, William T Harvey, Spyros Lytras, Ahmed Mohamed, Giulia Gallo, Nazia Thakur, Dami A Collier, Petra Mlcochova, COVID-19 Genomics UK (COG-UK) Consortium, Lidia M Duncan, Alessandro M Carabelli, Julia C Kenyon, Andrew M Lever, Anna de Marco, Christian Saliba, Katja Culap, Elisabetta Cameroni, Nicholas J Matheson, Luca Piccoli, Davide Corti, Leo C James, David L Robertson, Dalan Bailey, Ravindra K Gupta
Jul 29, 2021
Alpha Variant B.1.1.7 covid-19 SARS-CoV-2 Antibody Escape deletion infectivity neutralizing antibodies resistance spike mutation Animals Antibodies Neutralizing Antibodies Viral covid-19 Cell Line Chlorocebus aethiops HEK293 Cells Humans Immune Evasion Mutation Pandemics Phylogeny Protein Binding Recurrence SARS-CoV-2 Spike Glycoprotein Coronavirus Vero Cells
Sullivan Endowment Provides Unrestricted Dollars to Winthrop
Winthrop University
Jan 01, 0001
Sullivan, of Lancaster, S.C., who died in 2010, spent much of her working career as a home economics teacher and librarian at Buford High School in Lancaster. Three of Sullivan's four sisters also attended Winthrop. They are...
Published by: Winthrop University
Investigating the roles of kappa opioid receptors in neurochemical changes caused by stress and drugs of abuse
Introduction: Kappa opioid receptors (KOPrs) are involved in both stress responses and addiction-related behaviour (1). We are using an immunohistochemical approach to investigate brain regions that are activated by stress and...
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