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Results: 318
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18 F-GE-180 and comparison with 18 F-FDG and DCE-MRI
Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer, Pilar Jimenez-Royo
Dec 22, 2020
Abstract: Purpose: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Feb 13, 2020
PURPOSE: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Human Lymph Node Stromal Cells Have the Machinery to Regulate Peripheral Tolerance during Health and Rheumatoid Arthritis.
Janine S Hähnlein, Reza Nadafi, Tineke A de Jong, Johanna F Semmelink, Ester BM Remmerswaal, Mary Safy, Krijn P van Lienden, Mario Maas, Danielle M Gerlag, Paul P Tak, Reina E Mebius, Heidi Wähämaa, Anca I Catrina, Lisa G M van Baarsen
Aug 10, 2020
BACKGROUND: In rheumatoid arthritis (RA) the cause for loss of tolerance and anti-citrullinated protein antibody (ACPA) production remains unidentified. Mouse studies showed that lymph node stromal cells (LNSCs) maintain...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Jan 27, 2020
PURPOSE:While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry.
Jennie HM Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M Tannahill, Andrew R Beaton, Danielle M Gerlag, Caroline OS Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M Dayan, Timothy IM Tree
Jan 03, 2020
Background: Ultrasound guided sampling of human lymph node (LN) combined with advanced flow cytometry allows phenotypic analysis of multiple immune cell subsets. These may provide insights into immune processes and responses to...
Pivoting to Deeper Experiences in Education
The COVID-19 pandemic led educators to quickly pivot to continue teaching. Negative effects include exacerbated academic achievement gaps between SES groups, less access to health services, aggravated digital divides, widened...
Published by: IGI Global Scientific Publishing
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Andrew YF Li Yim, Enrico Ferrero, Klio Maratou, Huw D Lewis, George Royal, David F Tough, Chris Larminie, Marcel MAM Mannens, Peter Henneman, Wouter J de Jonge, Marleen GH van de Sande, Danielle M Gerlag, Rab K Prinjha, Paul P Tak
May 06, 2021
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative...
DNA Methylation Arthralgia multi-omics analyses rheumatoid arthritis synovial biopsies target identification transcriptomics Adult Aged Aged 80 and over Arthralgia Arthritis Rheumatoid Arthroscopy Biopsy DNA Methylation Epigenesis Genetic Female Humans Male Middle Aged RNA-seq Severity of Illness Index Synovial Membrane whole genome sequencing Young Adult
Learning Center Professionals Gathered at Winthrop to Learn Tutoring Tips
Winthrop University
Jan 01, 0001
The theme for this second annual conference was "Soaring to Success: Reaching New Heights with our Centers, Staff, and Students." Winthrop faculty and staff members taught two of the break-out sessions: Reaching New Heights: Be...
Published by: Winthrop University
Examining assisted living residents' participation in a group-based art therapy program
In May 2015, Ms. Hebert & Dr. Gibson received $1,483.00 from Winthrop University's Research Council to fund the research project, Examining Assisted Living Residents' Participation in a Group-Based Art Therapy Program. The aim...
Published by: Winthrop University
Charismatic Leadership and Vulnerability: A Comprehensive Study of Cult Dynamics
Danielle Santana Denrich
Jan 01, 0001
The term "cult" has various definitions in academic discourse, including religious or quasi-religious groups and small, ideologically aligned communities. This paper explores the complexity of the term, its alternative labels...
cults dynamics personality leadership vulnerability narcissism Personality and Social Contexts Psychology Social Psychology
Published by: Ursinus College
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
Mar 28, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Review of “Deadly Medicines and Organised Crime
Jessica Danielle Taylor
Jan 29, 2015
The following is a review of Peter Gøtzsche's "Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare," which focuses on the corruption that exists in the pharmaceutical industries and in the healthcare...
Published by: Memorial University of Newfoundland
Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis.
Janne W Bolt, Arno W van Kuijk, Marcel BM Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M Gerlag, Paul P Tak, Marleen G van de Sande, Maria C Lebre, Lisa GM van Baarsen
Jan 30, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether...
Web-Based DSS for Resource Allocation in Higher Education
Carolina Martins, Pascale Zaraté, Adiel Teixeira de Almeida, Jônatas Araújo de Almeida, Danielle Morais
Oct 01, 2021
The allocation of scarce resources is a complex higher education decision problem, especially when it comes to budget constraints. Therefore, the authors propose a multicriteria web-based decision support system for resource...
Published by: IGI Global Scientific Publishing
Optimizing the Quantification of the Degradation of PET?
Danielle Hanna
Jan 01, 0001
The world is in crisis due to excess plastic waste. Each year, 400 tons are produced globally, and with no effective or safe way for their degradation, plastic waste is increasing uncontrollably. The increasing plastic waste is...
Published by: Ursinus College
Artificially generated turbulence
Building on a summary of how turbulence influences biological systems, we reviewed key phytoplankton-turbulence laboratory experiments (after Peters and Redondo (1997) and Peters and Marrasé (2000)) to provide a current overview...
A new reporter cell line for studies with proteasome inhibitors in Trypanosoma brucei.
A Trypanosoma brucei cell line is described that produces a visual readout of proteasome activity. The cell line contains an integrated transgene encoding an ubiquitin-green fluorescent protein (GFP) fusion polypeptide...
Review of “Deadly Medicines and Organised Crime
Jessica Danielle Taylor
Jan 29, 2015
The following is a review of Peter Gøtzsche's "Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare," which focuses on the corruption that exists in the pharmaceutical industries and in the healthcare...
Published by: Memorial University of Newfoundland
Vulnerability to G - Quadruplexes in BRCA2 - Null Medulloblastoma: A Protective Role for the PIF1 Helicase
Danielle L Keahi
Jan 01, 0001
The reasons why cancer arises in children are not fully understood. Children with biallelic mutations in the essential DNA repair factor BRCA2 are highly predisposed to develop the most common pediatric brain cancer...
Published by: Rockefeller University
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