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Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid.
Debora Zanolla, Lara Gigli, Dritan Hasa, Michele R Chierotti, Mihails Arhangelskis, Nicola Demitri, Bill Jones, Dario Voinovich, Beatrice Perissutti
Oct 03, 2021
Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1...
Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties.
Debora Zanolla, Dritan Hasa, Mihails Arhangelskis, Gabriela Schneider-Rauber, Michele R Chierotti, Jennifer Keiser, Dario Voinovich, William Jones, Beatrice Perissutti
Jun 15, 2020
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of...
Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties.
Debora Zanolla, Dritan Hasa, Mihails Arhangelskis, Gabriela Schneider-Rauber, Michele R Chierotti, Jennifer Keiser, Dario Voinovich, William Jones, Beatrice Perissutti
Apr 30, 2020
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of...
Polymorphism Praziquantel mechanochemistry racemic compound liquid-assisted grinding neat grinding crystal structure solution hemihydrate
Published by: Pharmaceutics
Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid.
Debora Zanolla, Lara Gigli, Dritan Hasa, Michele R Chierotti, Mihails Arhangelskis, Nicola Demitri, William Jones, Dario Voinovich, Beatrice Perissutti
Jan 06, 2022
Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1...
Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties
Debora Zanolla, Dritan Hasa, Mihails Arhangelskis, Gabriela Schneider-Rauber, Michele R. Chierotti, Jennifer Keiser, Dario Voinovich, William Jones, Beatrice Perissutti
Mar 25, 2020
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of...
Mechanochemical reactivity inhibited, prohibited and reversed by liquid additives
Mihails Arhangelskis, Dejan-Krešimir Bučar, Simone Bordignon, Michele R Chierotti, Samuel A Stratford, Dario Voinovich, William Jones, Dritan Hasa
Jul 28, 2021
We demonstrate that liquid additives can exert inhibitive or prohibitive effects on the mechanochemical formation of multi-component molecular crystals, and report that certain additives unexpectedly prompt the dismantling of...
A Contextualization of the Technology Acceptance Model to Social Media Adoption Among University Students in Cameroon
The outbreak of the World Wide Web and of web 2.0 technologies, coupled with various increased forms of social interaction on globalized digital networks, has not spared higher education in Sub-Saharan Africa. Through social...
Published by: IGI Global Scientific Publishing
Time-based calibrations of pressure sensors improve the estimation of force signals containing impulsive events
Piezoresistive pressure sensors are widely used in biomechanics applications involving both static and dynamic loading conditions. The overall accuracy of these sensors has been reported previously in the literature, and...
The vertical excursion of the body visceral mass during vertical jumps is affected by specific respiratory maneuver
Most of the inverse modelling of body dynamics in sports assumes that every segment is ‘rigid’ and moves ‘as a whole’, although we know that uncontrolled wobbling masses exist and in specific condition their motion should be...
On the absence of asymmetric wakes for periodically plunging finite wings
It has previously been shown that, at high Strouhal numbers, oscillating airfoils can produce deflected jets that can create very high lift-coefficients for otherwise symmetric scenarios. These deflected jets form through...
An Observational Survey Study on the Use of Locoregional Anaesthesia in Non-Conventional Species
The objectives of this study were to investigate the current attitudes of veterinarians towards the use of locoregional anaesthesia in non-conventional animal species and to identify areas for future useful research on this...
Three-dimensional measurements of vortex breakdown
Leading-edge vortex formation and breakdown have been measured over a periodically plunging non-slender delta wing at a high angle of attack, using a three-dimensional particle-tracking method. A very rare type of vortex...
Time-based calibrations of pressure sensors improve the estimation of force signals containing impulsive events
Piezoresistive pressure sensors are widely used in biomechanics applications involving both static and dynamic loading conditions. The overall accuracy of these sensors has been reported previously in the literature, and...
Pre-binding prior to full engagement improves loading conditions for front-row players in contested rugby union scrums
We investigated the effect of a ‘PreBind’ engagement protocol on the biomechanics of contested Rugby Union scrummaging at different playing levels. ‘PreBind’ requires front-row props to take a bind on opposing players prior to...
Pre-binding prior to full engagement improves loading conditions for front-row players in contested rugby union scrums
We investigated the effect of a ‘PreBind’ engagement protocol on the biomechanics of contested Rugby Union scrummaging at different playing levels. ‘PreBind’ requires front-row props to take a bind on opposing players prior to...
Three-dimensional measurements of vortex breakdown
Leading-edge vortex formation and breakdown have been measured over a periodically plunging non-slender delta wing at a high angle of attack, using a three-dimensional particle-tracking method. A very rare type of vortex...
Can coordination variability identify performance factors and skill level in competitive sport? The case of race walking
Background: Marginal changes in the execution of competitive sports movements can represent a significant change for performance success. However, such differences may emerge only at certain execution intensities and are not...
Specific tackling situations affect the biomechanical demands experienced by rugby union players
Tackling in Rugby Union is an open skill which can involve high-speed collisions and is the match event associated with the greatest proportion of injuries. The purpose of this study was to analyse the biomechanics of rugby...
Specific tackling situations affect the biomechanical demands experienced by rugby union players
Tackling in Rugby Union is an open skill which can involve high-speed collisions and is the match event associated with the greatest proportion of injuries. The purpose of this study was to analyse the biomechanics of rugby...
Thrust enhancement due to flexible trailing-edge of plunging foils
Drag reduction for hydrofoils is studied through thrust generation on foils plunging at low Strouhal numbers in order to simulate the action of the ocean waves. Force, deformation and flow field measurements are presented for a...
On the absence of asymmetric wakes for periodically plunging finite wings
It has previously been shown that, at high Strouhal numbers, oscillating airfoils can produce deflected jets that can create very high lift-coefficients for otherwise symmetric scenarios. These deflected jets form through...
Periodically plunging foil near a free surface
Experiments were performed to investigate the effects of amplitude and depth on the drag reduction of a NACA 0012 airfoil plunging near a free surface for a range of frequencies. Beyond the effect of the free surface, at low...
Dual mode imaging in mid infrared with thermal signal reconstruction for innovative diagnostics of the "Monocromo" by Leonardo da Vinci.
Dual mode imaging in the mid infrared band, a joint use of thermography and quasi-thermal reflectography, was recently proposed as a full field diagnostic tool in cultural heritage. Here we discuss for the first time, to the...
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