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Optimal Timing of External Ventricular Drainage after Severe Traumatic Brain Injury
Charlene YC Chau, Saniya Mediratta, Mikel A Mckie, Barbara Gregson, Selma Tulu, Ari Ercole, Davi JF Solla, Wellingson S Paiva, Peter J Hutchinson, Angelos G Kolias
Jun 25, 2020
External ventricular drainage (EVD) may be used for therapeutic cerebrospinal fluid (CSF) drainage to control intracranial pressure (ICP) after traumatic brain injury (TBI). However, there is currently uncertainty regarding the...
Neurosurgeons’ experiences of conducting and disseminating clinical research in low- and middle-income countries
Charlotte J Whiffin, Brandon G Smith, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Davi J Fontoura Solla, Peter J Hutchinson, Angelos Kolias
Aug 13, 2020
Introduction: Low-income and middle-income countries (LMICs) face the greatest burden of neurotrauma. However, most of the research published in scientific journals originates from high-income countries, suggesting those in...
Incremental Prognostic Value of Coagulopathy in Addition to the Crash Score in Traumatic Brain Injury Patients.
Davi J Fontoura Solla, Robson Luis Oliveira de Amorim, Angelos G Kolias, Peter J Hutchinson, Almir Ferreira De Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
May 12, 2020
Incremental Prognostic Value of Coagulopathy in Addition to the Crash Score in Traumatic Brain Injury Patients
Davi J. Fontoura Solla, Robson Luis Oliveira de Amorim, Angelos G. Kolias, Peter J. Hutchinson, Almir Ferreira De Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
May 22, 2021
Abstract: Background/objective: Multivariable prognostic scores play an important role for clinical decision-making, information giving to patients/relatives, benchmarking and guiding clinical trial design. Coagulopathy has been...
The extravasation of contrast as a predictor of cerebral hemorrhagic contusion expansion, poor neurological outcome and mortality after traumatic brain injury
Isabella Vargas Baldon, Andre Candeas Amorim, Larissa Marques Santana, Davi J Solla, Angelos Kolias, Peter Hutchinson, Wellingson S Paiva, Marcos Rosa-Júnior
Sep 09, 2020
BACKGROUND: The active extravasation of contrast on CT angiography (CTA) in primary intracerebral hemorrhages (ICH) is recognized as a predictive factor for ICH expansion, unfavorable outcomes and mortality. However, few studies...
Neurosurgeons’ experiences of conducting and disseminating clinical research in low- and middle-income countries
Charlotte J Whiffin, Brandon G Smith, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Davi J Fontoura Solla, Peter J Hutchinson, Angelos Kolias
Aug 18, 2020
Low-income and middle-income countries (LMICs) face the greatest burden of neurotrauma. However, most of the research published in scientific journals originates from high-income countries, suggesting those in LMICs are either...
Spin in the neurosurgical trauma literature
João Vitor Miranda Porto Oliveira, André Luiz Freitas Oliveira Júnior, Angelos G Kolias, Wellingson S Paiva, Davi Jorge Fontoura Solla
Jan 10, 2022
INTRODUCTION: Spin is defined as an inaccurate interpretation of results, intentionally or not, leading to equivocal conclusions and misdirecting readers to look at the data in an overly optimistic way. Previous studies have...
Optimal Timing of External Ventricular Drainage after Severe Traumatic Brain Injury
Charlene Y. C. Chau, Saniya Mediratta, Mikel A. McKie, Barbara Gregson, Selma Tulu, Ari Ercole, Davi J. F. Solla, Wellingson S. Paiva, Peter J. Hutchinson, Angelos G. Kolias
Jun 27, 2020
External ventricular drainage (EVD) may be used for therapeutic cerebrospinal fluid (CSF) drainage to control intracranial pressure (ICP) after traumatic brain injury (TBI). However, there is currently uncertainty regarding the...
Incremental Prognostic Value of Coagulopathy in Addition to the Crash Score in Traumatic Brain Injury Patients
Davi J. Fontoura Solla, Robson Luis Oliveira de Amorim, Angelos G. Kolias, Peter J. Hutchinson, Almir Ferreira De Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Mar 09, 2021
Abstract: Background/objective: Multivariable prognostic scores play an important role for clinical decision-making, information giving to patients/relatives, benchmarking and guiding clinical trial design. Coagulopathy has been...
Neurosurgeons' experiences of conducting and disseminating clinical research in low-income and middle-income countries
Charlotte Jane Whiffin, Brandon George Smith, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Peter John Hutchinson, Angelos G Kolias, Davi Jorge Fontoura Solla, Wellingson S Paiva, Anthony Figaji
Sep 27, 2021
OBJECTIVES: Low-income and-middle-income countries (LMICs) are increasing investment in research and development, yet there remains a paucity of neurotrauma research published by those in LMICs. The aim of this study was to...
The extravasation of contrast as a predictor of cerebral hemorrhagic contusion expansion, poor neurological outcome and mortality after traumatic brain injury
Isabella Vargas Baldon, Andre Candeas Amorim, Larissa Marques Santana, Davi J. Solla, Angelos Kolias, Peter Hutchinson, Wellingson S. Paiva, Marcos Rosa-Júnior
Jul 07, 2020
Background: The active extravasation of contrast on CT angiography (CTA) in primary intracerebral hemorrhages (ICH) is recognized as a predictive factor for ICH expansion, unfavorable outcomes and mortality. However, few studies...
Neurotrauma clinicians' perspectives on the contextual challenges associated with traumatic brain injury follow up in low-income and middle-income countries
Brandon G Smith, Charlotte J Whiffin, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Davi J Fontoura Solla, Bhagavatula Indira Devi, Wellingson S Paiva, Franco Servadei, Peter J Hutchinson, Angelos G Kolias, Anthony Figaji, Andres M Rubiano
Oct 24, 2022
BACKGROUND: Traumatic brain injury (TBI) is a major global health issue, but low- and middle-income countries (LMICs) face the greatest burden. Significant differences in neurotrauma outcomes are recognised between LMICs and...
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
May 26, 2021
Background: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma.
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
Jul 09, 2021
BACKGROUND: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Neurotrauma clinicians' perspectives on the contextual challenges associated with long-term follow-up following traumatic brain injury in low-income and middle-income countries
Brandon George Smith, Charlotte Jane Whiffin, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Davi Jorge Fontoura Solla, Bhagavatula Indira Devi, Peter John Hutchinson, Angelos G Kolias, Anthony Figaji, Andres M Rubiano
Aug 24, 2021
INTRODUCTION: Traumatic brain injury (TBI) is a global public health concern; however, low/middle-income countries (LMICs) face the greatest burden. The WHO recognises the significant differences between patient outcomes...
Neurotrauma clinicians' perspectives on the contextual challenges associated with traumatic brain injury follow up in low-income and middle-income countries
Brandon G Smith, Charlotte J Whiffin, Ignatius N Esene, Claire Karekezi, Tom Bashford, Muhammad Mukhtar Khan, Davi J Fontoura Solla, Bhagavatula Indira Devi, Wellingson S Paiva, Franco Servadei, Peter J Hutchinson, Angelos G Kolias, Anthony Figaji, Andres M Rubiano
Sep 19, 2022
The scholar as craftsman
Seb Falk
Sep 05, 2018
The Royal Society Conversaziones were biannual social evenings at which distinguished guests could learn about the latest scientific developments. The Conversazione in May 1952 featured an object that came to be called King...
Decompressive craniotomy
Midhun Mohan, Hugo Layard Horsfall, Davi Jorge Fontoura Solla, Faith C Robertson, Amos O Adeleye, Tsegazeab Laeke Teklemariam, Muhammad Mukhtar Khan, Franco Servadei, Tariq Khan, Claire Karekezi, Andres M Rubiano, Peter J Hutchinson, Wellingson Silva Paiva, Angelos G Kolias, B Indira Devi, NIHR Global Health Research Group on Neurotrauma
Apr 19, 2021
Decompressive Craniectomy Decompressive craniotomy Floating craniotomy Hinge craniotomy Neurosurgery stroke Traumatic brain injury Adult Brain Injuries Traumatic Decompressive Craniectomy Health Knowledge Attitudes practice Hematoma Subdural Acute Humans Middle Aged Neurosurgeons Randomized Controlled Trials as Topic stroke Surveys and Questionnaires
Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae.
Stefanie Hampel, Katharina Eichler, Daichi Yamada, Davi D Bock, Azusa Kamikouchi, Andrew M Seeds
Jan 18, 2021
Diverse mechanosensory neurons detect different mechanical forces that can impact animal behavior. Yet our understanding of the anatomical and physiological diversity of these neurons and the behaviors that they influence is...
“Certainly Made by Ramsden”
Joshua Nall
May 18, 2021
Sometime in 1954, two young curators climbed into a 1936 Morris 8 and drove the fifty-some miles from Cambridge to Chigwell. The car’s driver, Rupert Hall, later admitted that this journey was a bit of a stretch for the small...
Published by: Bulletin of the Scientific Instrument Society
Topical bio(in)equivalence of metronidazole formulations in vivo
Thalita Pedon de Araujo, Isabelle Moura Fittipaldi, Danilo Cesar Galindo Bedor, Maira Ludna Duarte, Sarah Cordery, Richard Guy, Maria Delgado-Charro, Davi Pereira de Santana, Leila Bastos Leal
Apr 25, 2018
The topical bioavailabilities of metronidazole from a commercially available ‘reference’ product (Rozex®) and two extemporaneous test formulations were compared. With the reference drug product, a full skin pharmacokinetic...
Topical bio(in)equivalence of metronidazole formulations in vivo
Thalita Pedon de Araujo, Isabelle Moura Fittipaldi, Danilo Cesar Galindo Bedor, Maira Ludna Duarte, Sarah Cordery, Richard Guy, Maria Delgado-Charro, Davi Pereira de Santana, Leila Bastos Leal
Apr 25, 2018
The topical bioavailabilities of metronidazole from a commercially available ‘reference’ product (Rozex®) and two extemporaneous test formulations were compared. With the reference drug product, a full skin pharmacokinetic...
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