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Results: 45
The multimorbidity collaborative medication review and decision making (MyComrade) study
Collette Kirwan, Lisa Hynes, Nigel Hart, Sarah Mulligan, Claire Leathem, Laura McQuillan, Marina Maxwell, Emma Carr, Kevin Roche, Scott Walkin, Caroline McCarthy, Colin Bradley, Molly Byrne, Susan M Smith, Carmel Hughes, Maura Corry, Patricia M Kearney, Geraldine McCarthy, Margaret Cupples, Paddy Gillespie, Anna Hobbins, John Newell, Liam Glynn, Davood Roshan, Carol Sinnott, Andrew W Murphy
Oct 04, 2022
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
The multimorbidity collaborative medication review and decision making (MyComrade) study
Collette Kirwan, Lisa Hynes, Nigel Hart, Sarah Mulligan, Claire Leathem, Laura McQuillan, Marina Maxwell, Emma Carr, Kevin Roche, Scott Walkin, Caroline McCarthy, Colin Bradley, Molly Byrne, Susan M Smith, Carmel Hughes, Maura Corry, Patricia M Kearney, Geraldine McCarthy, Margaret Cupples, Paddy Gillespie, Anna Hobbins, John Newell, Liam Glynn, Davood Roshan, Carol Sinnott, Andrew W Murphy
Nov 04, 2022
BACKGROUND: While international guidelines recommend medication reviews as part of the management of multimorbidity, evidence on how to implement reviews in practice in primary care is lacking. The MyComrade (MultimorbiditY...
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer.
Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A Glynn, Grace Callagy
Oct 13, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
Graphene memristors based on humidity-mediated reduction of graphene oxide
Fatemeh Haghshenas gorgabi, Maria C. Morant-Miñana, Haniyeh Zafarkish, Davood Abbaszadeh, Kamal Asadi
Jan 16, 2023
Memristors have emerged as promising devices for neuromorphic applications, particularly as synaptic weight. Graphene oxide, a partially oxidised and electrically insulating form of graphene, has been employed in...
Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer
Darren Kilmartin, Mark O’Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Päivi Heikkilä, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchiò, Elena Provenzano, Peter Regitnig, Angelika Reiner, Aleš Ryška, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Davood Roshan, Sharon A. Glynn, Grace Callagy
Sep 02, 2021
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the...
Graphene memristors based on humidity-mediated reduction of graphene oxide
Fatemeh Haghshenas gorgabi, Maria C. Morant-Miñana, Haniyeh Zafarkish, Davood Abbaszadeh, Kamal Asadi
Jan 16, 2023
Memristors have emerged as promising devices for neuromorphic applications, particularly as synaptic weight. Graphene oxide, a partially oxidised and electrically insulating form of graphene, has been employed in...
microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells.
Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh, Beena Pillai
Aug 04, 2017
BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the...
Development of a new method to assess fuel saving using gear shift indicators
European regulations set the emissions requirements for new vehicles at 130 g CO2/km, with an additional 10 g CO2/km to be achieved by additional complementary measures, including gear shift indicators. However, there is...
Analysis of different uniflow scavenging options for a medium-duty 2-stroke engine for a U.S. light-truck application
Jamie Turner, Robert Head, Roshan Wijetunge, Junseok Chang, Nayan Engineer, Dave Blundell, Paul Burke
Oct 31, 2020
The work presented here seeks to compare different means of providing uniflow scavenging for a 2-stroke engine suitable to power a US light-duty truck. Through the ‘end-to-end’ nature of the uniflow scavenging process, it can in...
Analysis of different uniflow scavenging options for a medium-duty 2-stroke engine for a U.S. light-truck application
Jamie Turner, Robert Head, Roshan Wijetunge, Junseok Chang, Nayan Engineer, Dave Blundell, Paul Burke
Oct 31, 2020
The work presented here seeks to compare different means of providing uniflow scavenging for a 2-stroke engine suitable to power a US light-duty truck. Through the ‘end-to-end’ nature of the uniflow scavenging process, it can in...
2-Stroke Engine Options for Automotive Use:
James Turner, Robert A. Head, Junseok Chang, Nayan Engineer, Roshan S. Wijetunge, David W. Blundell, Paul Burke
Jan 15, 2019
The work presented here seeks to compare different means of providing scavenging systems for an automotive 2-stroke engine. It follows on from previous work solely investigating uniflow scavenging systems, and aims to provide...
DigitalAir<sup>™</sup> Camless FVVA System - Part 2, Gasoline Engine Performance Opportunities
Stephen J. Charlton, Charles E. Price, Jeff Rogers, Jamie Turner, Roshan S. Wijetunge, William Anderson
Mar 28, 2017
The paper describes a completely new approach to fully variable valve actuation (FVVA), which allows almost unlimited continuously variable control of intake and exhaust valve opening and closing events, and duration without...
Evaluation of NeuroPage as a memory aid for people with multiple sclerosis
Memory problems are reported in 40%-60% of people with multiple sclerosis (MS). These problems affect independence and may limit the ability to benefit from rehabilitation. Our aim was to evaluate the effectiveness of NeuroPage...
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
Development of a new method to assess fuel saving using gear shift indicators
European regulations set the emissions requirements for new vehicles at 130 g CO2/km, with an additional 10 g CO2/km to be achieved by additional complementary measures, including gear shift indicators. However, there is...
DigitalAir<sup>™</sup> Camless FVVA System - Part 2, Gasoline Engine Performance Opportunities
Stephen J. Charlton, Charles E. Price, Jeff Rogers, Jamie Turner, Roshan S. Wijetunge, William Anderson
Mar 28, 2017
The paper describes a completely new approach to fully variable valve actuation (FVVA), which allows almost unlimited continuously variable control of intake and exhaust valve opening and closing events, and duration without...
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
2-Stroke Engine Options for Automotive Use:
James Turner, Robert A. Head, Junseok Chang, Nayan Engineer, Roshan S. Wijetunge, David W. Blundell, Paul Burke
Jan 15, 2019
The work presented here seeks to compare different means of providing scavenging systems for an automotive 2-stroke engine. It follows on from previous work solely investigating uniflow scavenging systems, and aims to provide...
The impact of terrestrial protected areas on vegetation extent and condition
Roshan Sharma, Johanna Eklund, Megan Barnes, Jonas Geldmann, Judith Schleicher, Robert L. Pressey, Marco Gutierrez, Simon Jones, Ascelin Gordon
Jun 06, 2020
Abstract: Background: Establishing protected areas is a key approach to protecting nature. However, protected areas are often biased towards remote and less productive lands. It is important to evaluate the impacts protected...
Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke.
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
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