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An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Jul 28, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Sep 05, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
AXL cancer biology epigenetics erlotinib-resistant human Lung cancer Acrylamides Aniline Compounds Antineoplastic Agents Carcinoma Non-Small-Cell Lung Cell Line Tumor Drug Resistance Neoplasm Epigenesis Genetic ErbB Receptors Erlotinib Hydrochloride Humans Intercellular Signaling Peptides and Proteins Lung Neoplasms MicroRNAs Mutation Protein Kinase Inhibitors Proto-Oncogene Proteins RNA Messenger Receptor Protein-Tyrosine Kinases
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Aug 13, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
Published by: eLife
Studies Towards the Discovery of Novel Natural Products Through Functional Analysis of Environmental DNA-Encoded Type II Polyketide Synthases
Debjani Chakraborty
Jan 01, 0001
Natural products have historically served as a major source for most of the therapeutically relevant compounds. A significant fraction of these natural product-based drugs and leads are derived from microorganisms. Although the...
Published by: Rockefeller University
Implementing physically active learning
Andy Daly-Smith, Thomas Quarmby, Victoria SJ Archbold, Ash C Routen, Jade L Morris, Catherine Gammon, John B Bartholomew, Geir Kåre Resaland, Bryn Llewellyn, Richard Allman, Henry Dorling
Jun 21, 2019
Objective
Identify co-produced multi-stakeholder perspectives important for successful widespread physically active learning (PAL) adoption and implementation.
Method
A total of 35 stakeholders (policy makers, n = 9;...
Analysis of Heart Disease Using Parallel and Sequential Ensemble Methods With Feature Selection Techniques
This paper has organized a heart disease-related dataset from UCI repository. The organized dataset describes variables correlations with class-level target variables. This experiment has analyzed the variables by different...
Published by: IGI Global Scientific Publishing
Dynamic Combined Economic Emission Dispatch Including Wind Generators by Real Coded Genetic Algorithm
With the growing environmental depletion, the shift in the focus towards minimizing the emissions of gases released in the conventional generators and further incorporation of a cleaner alternate renewable source of energy such...
Published by: IGI Global Scientific Publishing
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Nov 22, 2021
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with...
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Sep 01, 2021
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with...
Optimization of Unit Commitment Problem Using Genetic Algorithm
The main objective of the paper is to minimize the use of conventional generators and optimize the fuel cost. To minimize the use of conventional generators, solar thermal power plant (STPP) is proposed in this paper. An...
Published by: IGI Global Scientific Publishing
An In Silico QSAR Model Study Using Electrophilicity as a Possible Descriptor Against T. Brucei
Human African trypanosomiasis (HAT) is a vector-borne sleeping sickness parasitic disease spread through the bite of infected tsetse flies (Glossina genus), which is highly populated in rural Africa. The present study...
Published by: IGI Global Scientific Publishing
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
Atiqul Haq Mazumder, Jennifer Barnett, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Jarmo Hietala, Erkki Isometsä, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Solja Niemelä, Jari Tiihonen, Tiina Paunio, Aarno Palotie, Jaana Suvisaari, Juha Veijola
May 24, 2021
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia...
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Jarmo Hietala, Erkki Tapio Isometsä, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Solja Niemelä, Jari Tiihonen, Tiina Paunio, Aarno Palotie, Jaana Suvisaari, Juha Veijola
Aug 16, 2021
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia...
Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Oct 29, 2021
The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with...
Published by: Brain sciences
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Jan 07, 2022
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous...
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Jarmo Hietala, Erkki Tapio Isometsä, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Solja Niemelä, Jari Tiihonen, Tiina Paunio, Aarno Palotie, Jaana Suvisaari, Juha Veijola
Jul 07, 2021
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia...
Published by: Brain sciences
Triplet Cooper pairs induced in diffusive s-wave superconductors interfaced with strongly spin-polarized magnetic insulators or half-metallic ferromagnets.
Interfacing superconductors with strongly spin-polarized magnetic materials opens the possibility to discover new spintronic devices in which spin-triplet Cooper pairs play a key role. Motivated by the recent derivation of...
Short-Term Load Forecasting for a Captive Power Plant Using Artificial Neural Network
The irregularity of Indian grid system increases, with increase in the power demand. The quality of power supplied by the power grid is also poor due to continuous variation in frequency and voltage. To overcome this problem of...
Published by: IGI Global Scientific Publishing
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Oct 29, 2021
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous...
Sentiment Analysis of Multilingual Tweets Based on Natural Language Processing (NLP)
Multilingual Sentiment analysis plays an important role in a country like India with many languages as the style of expression varies in different languages. The Indian people speak in total 22 different languages and with the...
Published by: IGI Global Scientific Publishing
Aliel
In Africa ERC Funded Project (ERC295907). Research was carried out through affiliation with the National Museums of Kenya (NMK/ ESC/PAL/w/VOL.1), with permission from the National Council of Science and Technology, Government of...
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