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Lysosome positioning and mTOR activity in Lowe syndrome.
Lowe syndrome is a rare, developmental disorder caused by mutations in the phosphatase, OCRL. A study in this issue of EMBO Reports shows that OCRL is required for microtubule nucleation and that mutations in this protein lead...
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L Medina, Andrea Ballabio, Maria Antonietta De Matteis
Sep 03, 2019
Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2...
Numbers as Narrative
Deborah Lefkowitz
Jun 01, 2023
Staging numbers powerfully shape breast cancer narratives. Used by physicians to tell women about their breast cancer diagnoses, these numbers are integral to treatment decision-making. In women's calculus of survival, staging...
Healthcare Administration Medicine and Healthcare Healthcare Administration Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Love of Traveling Sets the Tone for Special Recital Oct. 6
Winthrop University
Jan 01, 0001
Deborah Popham's concert will begin at 7:30 p.m. in Barnes on Oct. 6. It is a cultural event. On Tuesday, Oct. 7, Popham will give a master class to students at 11 a.m. in Barnes.
Published by: Winthrop University
Changing Hearts and Minds
By the nature of their occupation, first responders witness numerous traumatic events. Most of the time, their training and desire to help others allows them to respond professionally and appropriately. However, there are...
Mental Health & Behavioral Studies Medicine and Healthcare Psychiatry and Mental Health Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Thixotropic pumping in a cylindrical pipe
We consider the flow of a thixotropic fluid in a uniform cylindrical pipe, driven by an oscillating pressure gradient or a body force. For a variety of rheological models, solutions can be obtained by integrating ordinary rather...
Four Talented Women Artists to Discuss the Arts Industry at Latest Winthrop Women's Coalition Event
Winthrop University
Jan 01, 0001
Quick Facts
The Winthrop Women's Coalition will host a Women in the Arts panel discussion on March 1 at 7 p.m. Audrey Flack, Shanola Hampton, Deborah Obalil and Cary Perkins will discuss their careers and the arts industry. The...
Published by: Winthrop University
Thixotropic pumping in a cylindrical pipe
We consider the flow of a thixotropic fluid in a uniform cylindrical pipe, driven by an oscillating pressure gradient or a body force. For a variety of rheological models, solutions can be obtained by integrating ordinary rather...
Killing Kindly: Applying Jens Timmermann's Kantian Ethics of Animal Welfare to the Modern System of Livestock Farming
Alexander Lowe
Jan 01, 0001
This essay seeks to contribute to this conversation in an ethically applicable way, addressing specifically the Kantian vein of animal welfare discussed by Dr. Jens Timmermann in his essay When the Tail Wags the Dog: Animal...
Kantian ethics animal welfare Jens Timmermann Pain sentient animals food living conditions Diet slaughter Animal Husbandry animal rights Animal Studies Ethics and Political Philosophy
Published by: Ursinus College
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
Black Americans African Americans Distributive justice reparations John Rawls justice as fairness institutional racism reflective equilibrium difference principle equality of opportunity African American Studies Civil Rights and Discrimination Ethics and Political Philosophy Inequality and Stratification Race, Ethnicity and Post-Colonial Studies United States History
Published by: Ursinus College
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
Hidenori Taniguchi, Christopher E Lowe, Jason D Cooper, Deborah J Smyth, Rebecca Bailey, Sarah Nutland, Barry C Healy, Alex C Lam, Oliver Burren, Neil M Walker, Luc J Smink, Linda S Wicker, John A Todd
Jun 16, 2011
The Virtual Community of Practice Facilitation Model
This study examines the instructional design, learning experiences, and outcomes of a virtual community of practice (VCoP). In 2019, the Northern Ontario School of Medicine launched a continuing professional development program...
Published by: IGI Global Scientific Publishing
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
This essay seeks to expose the causational effects of various forms of distributive justice on wealth inequality within the United States of America. Herein, several frameworks of distributive justice are assessed through John...
Racism Distributive justice reflective equilibrium reparations Rawls slavery egalitarianism desert-based Black Americans wealth inequality African American Studies Arts and Humanities Inequality and Stratification Philosophy race and ethnicity
Published by: Ursinus College
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
Deborah J Smyth, Joanna MM Howson, Felicity Payne, Lisa M Maier, Rebecca Bailey, Kieran Holland, Christopher E Lowe, Jason D Cooper, John S Hulme, Adrian Vella, Ingrid Dahlman, Alex C Lam, Sarah Nutland, Neil M Walker, Rebecca CJ Twells, John A Todd
Jun 14, 2011
BACKGROUND: The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease...
GHG assessment of Bore Hill Farm Biodigester
This study takes the Bore Hill Farm Biodigester (BHFB) facility as a case study to explore the sources of Greenhouse Gas (GHG) emissions associated with commercial Anaerobic Digestion (AD), and some of the factors affecting...
Does Exposure to Noise During Military Service Affect the Progression of Hearing Loss with Increasing Age?
It is traditionally believed that the effects of exposure to noise cease once the exposure itself has ceased. If this is the case, exposure to noise relatively early in life, for example during military service, should...
Trauma Management Therapy for First Responders
Mental health professionals are only recently beginning to understand the risks for stress-related disorders experienced by first responders. For example, it is clear that first responders are at increased risk for...
Mental Health & Behavioral Studies Medicine and Healthcare Psychiatry and Mental Health Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Guidelines for Diagnosing and Quantifying Noise-Induced Hearing Loss
This paper makes recommendations for the diagnosis and quantification of noise-induced hearing loss (NIHL) in a medico-legal context. A distinction is made between NIHL produced by: steady broadband noise, as occurs in some...
Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins.
Consensus-designed tetratricopeptide repeat proteins are highly stable, modular proteins that are strikingly amenable to rational engineering. They therefore have tremendous potential as building blocks for biomaterials and...
A comparison of analytical techniques and the products formed during the decomposition of biodiesel under accelerated conditions
Christopher J Chuck, Christopher D Bannister, Rhodri W Jenkins, John P Lowe, Matthew G Davidson
Jun 01, 2012
Biodiesel is a renewable fuel synthesised from plant, waste or algal oils. Though biodiesel can be used as a replacement for diesel fuel, a number of technical issues, including the reduced oxidative stability, limit the...
Advancing tephrochronology as a global dating tool
Layers of far-travelled volcanic ash (tephra) from explosive volcanic eruptions provide stratigraphic and numerical dating horizons in sedimentary and volcanic sequences. Such tephra layers may be dispersed over tens to...
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