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Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.
David Paling, Esben Thade Petersen, Daniel J Tozer, Daniel R Altmann, Claudia AM Wheeler-Kingshott, Raju Kapoor, David H Miller, Xavier Golay
Jun 22, 2018
Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In...
Retail luxury strategy
Luxury retail strategy differs from other retail strategies not merely in distinctive formulations of product, price, distribution, and appeals to customer distinction. Instead, it increasingly stands or falls on the legitimacy...
NKG2A Immune Checkpoint in Vδ2 T Cells
Valentina Cazzetta, Delphine Depierreux, Francesco Colucci, Joanna Mikulak, Domenico Mavilio
Mar 28, 2023
Immune regulation has revolutionized cancer treatment with the introduction of T-cell-targeted immune checkpoint inhibitors (ICIs). This successful immunotherapy has led to a more complete view of cancer that now considers not...
NKG2A inhibitory receptors cancer immunotherapy γδ T cells Therapeutic monoclonal antibodies Immune Checkpoint Inhibitors
Published by: Cancers
EXPRESS: The Enrichment Economy
Rare watches, fine wines and spirits, sports cars, designer sneakers, and many other luxury goods create massive enrichment opportunities for consumers if they resell them on secondary markets. This trend is part of the...
Retail luxury strategy
Luxury retail strategy differs from other retail strategies not merely in distinctive formulations of product, price, distribution, and appeals to customer distinction. Instead, it increasingly stands or falls on the legitimacy...
EXPRESS: The Enrichment Economy
Rare watches, fine wines and spirits, sports cars, designer sneakers, and many other luxury goods create massive enrichment opportunities for consumers if they resell them on secondary markets. This trend is part of the...
Intergenerational Continuity of Intimate Partner Violence Perpetration
Intimate partner violence (IPV) is a continuum of abuse that is associated with a number of negative outcomes including substance misuse, depression, and suicidal ideation. This study aims to investigate the intergenerational...
The CANTOS Trial
The results of the CANTOS trial provide exciting evidence in support of the inflammatory hypothesis of atherosclerosis in humans, and is the first phase III clinical trial to show clinical benefit of a targeted anti-inflammatory...
Atherosclerosis Coronary Artery Disease Inflammation Interleukins translational medical research Anti-Inflammatory Agents Antibodies Monoclonal Antibodies Monoclonal Humanized Atherosclerosis Cardiology Clinical Trials Phase III as Topic Coronary Artery Disease Humans Randomized Controlled Trials as Topic Treatment Outcome
The Secretomes of Aspergillus japonicus and Aspergillus terreus Supplement the Rovabio® Enzyme Cocktail for the Degradation of Soybean Meal for Animal Feed.
Delphine Grandmontagne, David Navarro, Virginie Neugnot-Roux, Simon Ladevèze, Jean-Guy Berrin
Apr 08, 2021
One of the challenges of the 21st century will be to feed more than 10 billion people by 2050. In animal feed, one of the promising approaches is to use agriculture by-products such as soybean meal as it represents a rich source...
Beyond Maternal Tolerance
Delphine M Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
May 24, 2022
Reproductive immunology has moved on from the classical Medawar question of 60 years ago "why doesn't the mother reject the fetus?". Looking beyond fetal-maternal tolerance, modern reproductive immunology focuses on how the...
Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.
Jan J Zylicz, Sabine Dietmann, Ufuk Günesdogan, Jamie A Hackett, Delphine Cougot, Caroline Lee, M Azim Surani
Nov 24, 2015
Chromosomes developmental biology Epiblast epigenetics Genes histone MOUSE post-implantation primed pluripotency Stem Cells Animals Chromatin Embryonic Development Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation Developmental Histone-Lysine N-Methyltransferase Histones Methylation Mice Polycomb Repressive Complex 2 Protein Processing Post-Translational
KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
Alexandra Iouranova, Delphine Grun, Tamara Rossy, Julien Duc, Alexandre Coudray, Michael Imbeault, Jonas de Tribolet-Hardy, Priscilla Turelli, Alexandre Persat, Didier Trono
Feb 19, 2022
BACKGROUND: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the...
Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.
Delphine Larrieu, Emmanuelle Viré, Samuel Robson, Sophia Y Breusegem, Tony Kouzarides, Stephen P Jackson
Sep 20, 2018
Hutchinson-Gilford progeria syndrome (HGPS) is an incurable premature aging disease. Identifying deregulated biological processes in HGPS might thus help define novel therapeutic strategies. Fibroblasts from HGPS patients...
Active Transport Cell Nucleus Adult Aged 80 and over Case-Control Studies Cell Nucleus Cells Cultured Cellular Senescence Child Female FIBROBLASTS Humans Male Microtubules N-Terminal Acetyltransferase E N-Terminal Acetyltransferases Nuclear Pore Complex Proteins Phenotype progeria Proto-Oncogene Proteins Young Adult beta Karyopherins ran GTP-Binding Protein
CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.
Ting-Wei Will Chiang, Carlos le Sage, Delphine Larrieu, Mukerrem Demir, Stephen P Jackson
Apr 13, 2016
Alleles Base Sequence CRISPR-Cas Systems Cell Line Deoxyribonuclease I Drug Discovery Gene Editing Gene Knockout Techniques Gene Order Gene Targeting Genetic Loci Genetic Vectors Genomics Genotype High-Throughput Screening Assays Humans Mutagenesis Phenotype RNA Guide Kinetoplastida Vascular Endothelial Growth Factor A
KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
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