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Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
Peter Kirwan, Benita Turner-Bridger, Manuel Peter, Ayiba Momoh, Devika Arambepola, Hugh PC Robinson, Frederick J Livesey
Jul 30, 2015
Cerebral Cortex human Networks Neural development Stem Cells Cerebral Cortex Dendritic Spines Humans Image Processing Computer-Assisted In Vitro Techniques Microscopy Fluorescence Nerve Net Neuronal Plasticity Patch-Clamp Techniques Pluripotent Stem Cells Reverse Transcriptase Polymerase Chain Reaction Single-Cell Analysis Video Recording
Emerin modulates spatial organization of chromosome territories in cells on softer matrices.
Cells perceive and relay external mechanical forces into the nucleus through the nuclear envelope. Here we examined the effect of lowering substrate stiffness as a paradigm to address the impact of altered mechanical forces on...
Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus.
Devika Ranade, Roopali Pradhan, Muhunden Jayakrishnan, Sushmitha Hegde, Kundan Sengupta
Apr 06, 2020
BACKGROUND: Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus...
actin Chromosome territories Emerin Lamin A/C Nuclear myosin 1 NUCLEUS Actins Cell Line Tumor Cell Nucleus Chromatin Chromosome Positioning Chromosomes Human Pair 18 Chromosomes Human Pair 19 Cytoskeleton Gene Expression Regulation Neoplastic Gene Knockdown Techniques Genetic Loci Humans Interphase Kallikreins Lamin Type A Membrane Proteins Muscle Proteins Myosin Type I Nuclear Envelope Nuclear Proteins Polymerization Proto-Oncogene Proteins c-bcl-2 RNA Small Interfering Smad2 Protein Transfection
The systematic development of a mobile phone–delivered brief intervention for hazardous drinking in India
Abhijit Nadkarni, Sheina Costa, Devika Gupta, Danielle Fernandes, Alexander Catalano, Richard Velleman, Seema Sambari, Subhash Pednekar, Farah Hussain, Ethel D'Souza, Amruta Houde, Neal Chaudhuri, Anna Heath
Jul 01, 2021
Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous...
brief interventions hazardous drinking india intervention development mHealth /dk/atira/pure/subjectarea/asjc/2900/2921 name=Phychiatric Mental Health /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The systematic development of a mobile phone–delivered brief intervention for hazardous drinking in India
Abhijit Nadkarni, Sheina Costa, Devika Gupta, Danielle Fernandes, Alexander Catalano, Richard Velleman, Seema Sambari, Subhash Pednekar, Farah Hussain, Ethel D'Souza, Amruta Houde, Neal Chaudhuri, Anna Heath
Jul 01, 2021
Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous...
brief interventions hazardous drinking india intervention development mHealth /dk/atira/pure/subjectarea/asjc/2900/2921 name=Phychiatric Mental Health /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.
Andrew R Green, Mohammed A Aleskandarany, Devika Agarwal, Somaia Elsheikh, Christopher C Nolan, Maria Diez-Rodriguez, R Douglas Macmillan, Graham R Ball, Carlos Caldas, Srinivasan Madhusudan, Ian O Ellis, Emad A Rakha
Jan 11, 2018
BACKGROUND: MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates in many aspects of cellular function and is linked with therapeutic...
Aged Ataxia Telangiectasia Mutated Proteins Biomarkers Tumor Breast Neoplasms Class I Phosphatidylinositol 3-Kinases Cyclin B1 Cyclin E Disease-Free Survival Drug Resistance Neoplasm Endocrine Cells Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Phosphatidylinositol 3-Kinases Prognosis Proto-Oncogene Proteins c-myc RNA Messenger Receptor ErbB-2