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Immunization with Genetically Modified Trypanosomes Provides Protection against Transmissible Spongiform Encephalopathies.
Gianna Triller, Dimitrios A Garyfallos, F Nina Papavasiliou, Theodoros Sklaviadis, Pete Stavropoulos, Konstantinos Xanthopoulos
Oct 24, 2022
Transmissible spongiform encephalopathies are incurable neurodegenerative diseases, associated with the conversion of the physiological prion protein to its disease-associated counterpart. Even though immunization against...
Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.
Jian Yang, Sandeep S Rajan, Mathias J Friedrich, Guocheng Lan, Xiangang Zou, Hannes Ponstingl, Dimitrios A Garyfallos, Pentao Liu, Allan Bradley, Emmanouil Metzakopian
Feb 25, 2019
Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in...
CRISPR activation CRISPR screen activation screen Epiblast stem cells gain-of-function genome-wide screen Induced Pluripotent Stem Cells reprogramming reprogramming pathways Animals Biomarkers CRISPR-Cas Systems Cell Line Cellular Reprogramming Clustered Regularly Interspaced Short Palindromic Repeats Gene Dosage Genome-Wide Association Study Germ Layers Humans Induced Pluripotent Stem Cells Mice Octamer Transcription Factor-3 Pluripotent Stem Cells Transcription Factors
A Proposed Framework for Developing an Electronic Medical Record System
The deployment of an electronic medical records (EMR) raises several important issues. Those addressed in this study are the access to such a system, the satisfaction on the security and authorization protocols to follow, the...
Published by: IGI Global Scientific Publishing
City Branding and Video Production
Dimitrios Sidiropoulos
Jan 01, 2024
Today, branding directly affects the growth process for countries, regions, and urban centers. Particularly, a successful branding process, including the framework design and establishment of regulation tools, is necessary and...
Published by: IGI Global Scientific Publishing
INSIDE
The field of electronic games is a great experimental area that contributes to the implementation of new technologies in a variety of applications. This article explores the field of mixed reality through the use of physical...
Virtual Communities & Virtual Reality Computer Science and Information Technology Human-Computer Interaction Media and Communications Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Preliminary Results on the Online Lessons of IDPE Department of University of West Attica 2019-2020
Evangelos Papakitsos, Panagiotis Makrygiannis, Michail Papoutsidakis, Dimitrios Piromalis, Dimitrios Tseles
Jan 01, 2023
During the pandemic outbreak of COVID-19 in Greece that coincided with the spring semester of the year 2020, conventional face-to-face lessons presented a threat to public health. As a result, house confinement measures were...
Published by: IGI Global Scientific Publishing
Exchange Coupling Interactions from the Density Matrix Renormalization Group and N-Electron Valence Perturbation Theory
The accurate description of magnetic level energetics in oligonuclear exchange-coupled transition-metal complexes remains a formidable challenge for quantum chemistry. The density matrix renormalization group (DMRG) brings...
Exchange Coupling Interactions from the Density Matrix Renormalization Group and N-Electron Valence Perturbation Theory
The accurate description of magnetic level energetics in oligonuclear exchange-coupled transition-metal complexes remains a formidable challenge for quantum chemistry. The density matrix renormalization group (DMRG) brings...
INSIDE
The field of electronic games is a great experimental area that contributes to the implementation of new technologies in a variety of applications. This article explores the field of mixed reality through the use of physical...
Published by: IGI Global Scientific Publishing
Simulation Modeling and Analysis of a Door Industry
Ιn this paper, the authors study the production line of a door industry. The first stage of this research consists of the detailed documentation with flow charts and systematization of all production processes, all product...
Published by: IGI Global Scientific Publishing
Orientation selectivity in a multi-gated organic electrochemical transistor.
Paschalis Gkoupidenis, Dimitrios A Koutsouras, Thomas Lonjaret, Jessamyn A Fairfield, George G Malliaras
Mar 27, 2018
UNLABELLED: Neuromorphic devices offer promising computational paradigms that transcend the limitations of conventional technologies. A prominent example, inspired by the workings of the brain, is spatiotemporal information...
Future priorities for a climate-friendly transport
Alessandro Luè, Chiara Bresciani, Alberto Colorni, Federico Lia, Vladislav Maras, Zoran Radmilović, Lorraine Whitmarsh, Dimitrios Xenias, Eleni Anoyrkati
Mar 15, 2016
Research is a key factor for a successful reduction in greenhouse gas (GHG) emissions from transport. This article summarizes the main results of REACT, a project cofinanced by the European Commission, which aimed to develop...
Neuromorphic device architectures with global connectivity through electrolyte gating.
Information processing in the brain takes place in a network of neurons that are connected with each other by an immense number of synapses. At the same time, neurons are immersed in a common electrochemical environment, and...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Dual-Level Evaluation Framework for Airport User Satisfaction
Passenger's satisfaction evaluation is very complicated for transport infrastructure services that accommodate high demand, mainly due to international passenger's quality attitudes, expectations, and experiences. This paper...
Published by: IGI Global Scientific Publishing
Chronological Age Affects MSC Senescence In Vitro—A Systematic Review
Konstantinos Kapetanos, Dimitrios Asimakopoulos, Neophytos Christodoulou, Antonia Vogt, Wasim Khan
Jul 28, 2021
The use of mesenchymal stromal cells (MSCs) in regenerative medicine and tissue engineering is well established, given their properties of self-renewal and differentiation. However, several studies have shown that these...
Logistics Services Sector and Economic Recession in Greece
The recent economic recession in Greece has had a detrimental impact on all national business activities, with the logistics industry being one of the most affected sectors primarily due to the significant decrease in...
The strategic and political consequences of the June 1967 war
Dimitrios Machairas
Mar 07, 2017
This article analyses the direct, relatively immediate strategic and political consequences of the 1967 Arab-Israeli War, focusing on Israel’s post-war security situation, the connection of the Six-Day War with the next episodes...
A Systematic Review on Augmented Reality Applications in Informal Learning Environments
In recent years more and more people use their mobile phones daily for work or entertainment. The increasing use of mobile devices has led researchers to seek new ways of learning with their support, beyond the confines of...
Published by: IGI Global Scientific Publishing
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, MS Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D Toop, Monika Dudek, Samuel C Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A Garyfallos, Hannes Ponstingl, Joao ML Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J Bannister, Roland Rad, Rab K Prinjha, John C Marioni, Brian Huntly, Jennifer Batson, Jonathan C Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O Bates, Kosuke Yusa, Tony Kouzarides, George S Vassiliou
Jan 08, 2019
We recently identified the splicing kinase gene SRPK1 as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell...
Chronological Age Affects MSC Senescence In Vitro-A Systematic Review.
Konstantinos Kapetanos, Dimitrios Asimakopoulos, Neophytos Christodoulou, Antonia Vogt, Wasim Khan
Sep 08, 2021
The use of mesenchymal stromal cells (MSCs) in regenerative medicine and tissue engineering is well established, given their properties of self-renewal and differentiation. However, several studies have shown that these...
Does Gold Offer a Better Protection Against Losses in Sovereign Debt Bonds than Other Precious Metals
It is a commonly held view that gold protects investors’ wealth in the event of negative economic conditions. In this study, we test whether other metals offer similar or better investment opportunities in periods of market...
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