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Colloidal liquid crystals in rectangular confinement
Alexander Lewis, Ioana Garlea, José Alvarado, Oliver Dammone, Peter Howell, A Majumdar, Bela Mulder, M. P. Lettinga, Gijsje Koenderink, Dirk Aarts
Oct 21, 2014
We theoretically and experimentally study nematic liquid crystal equilibria within shallow rectangular wells. We model the wells within a two-dimensional Oseen–Frank framework, with strong tangent anchoring, and obtain explicit...
Legionella pneumophila Pathogenesis in the Galleria mellonella Infection Model
C. R. Harding, G. N. Schroeder, S. Reynolds, A. Kosta, J. W. Collins, A. Mousnier, G. Frankel
Aug 01, 2012
Legionella pneumophila is a facultative intracellular human pathogen and the etiological agent of severe pneumonia known as Legionnaires' disease. Its virulence depends on protein secretion systems, in particular, the Dot/Icm...
Legionella pneumophila Pathogenesis in the Galleria mellonella Infection Model
C. R. Harding, G. N. Schroeder, S. Reynolds, A. Kosta, J. W. Collins, A. Mousnier, G. Frankel
Aug 01, 2012
Legionella pneumophila is a facultative intracellular human pathogen and the etiological agent of severe pneumonia known as Legionnaires' disease. Its virulence depends on protein secretion systems, in particular, the Dot/Icm...
Coupling of Dimensionality Reduction and Stacking Ensemble Learning for Smartphone-Based Human Activity Recognition
Human activity recognition (HAR) plays a vital role in the field of ambient assisted living (AAL) for the welfare of the elders who live alone in the home. AAL provides service through ambient sensors, vision systems, smartphone...
Published by: IGI Global Scientific Publishing
A Novel Framework Using Zero Shot Learning Technique for a Non-Factoid Question Answering System
Non-Factoid Question Answering (QA) is the next generation of textual QA systems, which gives passage level summaries for a natural language query, posted by the user. The main issue lies in the appropriateness of the generated...
Published by: IGI Global Scientific Publishing
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.
Huaidong Du, Daphne L van der A, Vanessa Ginder, Susan A Jebb, Nita G Forouhi, Nicholas J Wareham, Jytte Halkjaer, Anne Tjønneland, Kim Overvad, Marianne Uhre Jakobsen, Brian Buijsse, Annika Steffen, Domenico Palli, Giovanna Masala, Wim HM Saris, Thorkild IA Sørensen, Edith JM Feskens
Mar 21, 2018
BACKGROUND: Experimental studies show that a reduction in dietary energy density (ED) is associated with reduced energy intake and body weight. However, few observational studies have investigated the role of ED on long-term...
3D printed customised external cranial plate in a patient with syndrome of trephined
Mee H., Greasley S., Whiting G., Harkin C., Oliver G., Marsden D., Andrews R., Sireau S., Price RD., Anwar F., Timofeev IS., Hutchinson PJ., White PA., Helmy A.
Nov 22, 2021
Abstract: Background: Syndrome of the trephined is a well-recognised phenomenon that occurs in patients following a craniectomy. It is associated with several symptoms, including headaches, motor impairments, cognitive disorders...
Capturing the systemic immune signature of a norovirus infection
A J. Cutler, J Oliveira, R C. Ferreira, B Challis, N M. Walker, S Caddy, J Lu, H E. Stevens, D J. Smyth, M L. Pekalski, J Kennet, K M.D. Hunter, I Goodfellow, L S. Wicker, J A. Todd, F Waldron-Lynch
Jun 30, 2017
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
In the early-diverging protozoan parasite Plasmodium , few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of...
James Edwards-Smallbone, Anders L Jensen, Lydia E Roberts, Francis Isidore G Totañes, Sarah R Hart, Catherine J Merrick
Mar 08, 2022
Colloidal liquid crystals in rectangular confinement
Alexander Lewis, Ioana Garlea, José Alvarado, Oliver Dammone, Peter Howell, A Majumdar, Bela Mulder, M. P. Lettinga, Gijsje Koenderink, Dirk Aarts
Oct 21, 2014
We theoretically and experimentally study nematic liquid crystal equilibria within shallow rectangular wells. We model the wells within a two-dimensional Oseen–Frank framework, with strong tangent anchoring, and obtain explicit...
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Dec 12, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
‘‘Ignore Mouth-Ignore Life’’ A Cross Sectional Study on Oral Cancer Awareness among General Medical Practitioners and General Dental Practitioners.
Harshavardhan T, Vijayalaxmi Nimma, Sindhuri Tadisetti*, Madhulatha G, Shailender Reddy A, Jayakrishna B
Jun 14, 2015
Aims and objectives: The aim of the present study is to assess the oral cancer awareness, knowledge, attitude and screening practices among general medical practitioners (GMPs) and general dental practitioners (GDPs).
Materials...
Published by: IJHS Medical Association
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
L-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression.
Naveed Malek, Sofia Kanavou, Michael A Lawton, Vanessa Pitz, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Nigel M Williams, Nicholas Wood, Huw R Morris, Donald G Grosset, PRoBaND clinical consortium
Jul 25, 2019
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates and significance of this are ill-defined. METHODS: Patients were assessed before and after their usual morning L-dopa dose, using...
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
Pooja Gupta, Sherine E Thomas, Shaymaa A Zaidan, Maria A Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G Coyne, William R Jacobs, Tom L Blundell, Sangeeta Tiwari, Vítor Mendes
Sep 02, 2021
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in...
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