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Results: 8708
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex
Nia Marrott, Jacqueline J. T. Marshall, Dmitri I Svergun, Susan Crennell, D W Hough, Jean Van Den Elsen, Michael Danson
Nov 01, 2014
The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active multienzyme complex possessing activity with the branched-chain 2-oxoacids...
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex
Nia Marrott, Jacqueline J. T. Marshall, Dmitri I Svergun, Susan Crennell, D W Hough, Jean Van Den Elsen, Michael Danson
Nov 01, 2014
The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active multienzyme complex possessing activity with the branched-chain 2-oxoacids...
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Cynthia Tallant, Erica Valentini, Oleg Fedorov, Lois Overvoorde, Fleur M Ferguson, Panagis Filippakopoulos, Dmitri I Svergun, Stefan Knapp, Alessio Ciulli
Feb 03, 2015
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
Predrag Kukic, Giuseppe Mattia Lo Piccolo, Marcela O Nogueira, Dmitri I Svergun, Michele Vendruscolo, Isabella C Felli, Roberta Pierattelli
Mar 29, 2019
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein.
Dominika T Gruszka, Fiona Whelan, Oliver E Farrance, Herman KH Fung, Emanuele Paci, Cy M Jeffries, Dmitri I Svergun, Clair Baldock, Christoph G Baumann, David J Brockwell, Jennifer R Potts, Jane Clarke
May 27, 2015
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
Yi Yang, Catherine Back, Melissa Gräwert, Ayla Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri i. Svergun, Asel Sartbaeva, Andrew Watts, Kevin J Marchbank, Johannes Van Den Elsen
Jan 11, 2019
Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation. Consequently, fusions of antigens with C3d...
Adjuvant complement Immune Evasion Staphycoccus aureus vaccine /dk/atira/pure/subjectarea/asjc/2700/2723 name=Immunology and Allergy /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
Yi Yang, Catherine Back, Melissa Gräwert, Ayla Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri i. Svergun, Asel Sartbaeva, Andrew Watts, Kevin J Marchbank, Johannes Van Den Elsen
Jan 11, 2019
Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation. Consequently, fusions of antigens with C3d...
Adjuvant complement Immune Evasion Staphycoccus aureus vaccine /dk/atira/pure/subjectarea/asjc/2700/2723 name=Immunology and Allergy /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Insights into herpesvirus assembly from the structure of the pUL7
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
May 11, 2020
focal adhesions human cytomegalovirus (HCMV) infectious disease microbiology molecular biophysics secondary envelopment small-angle X-ray scattering (SAXS) structural biology Virus virus budding HEK293 Cells HeLa Cells Herpes Simplex Herpesvirus 1 Human Humans Models Molecular Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Quaternary Protein Structure Tertiary Viral Matrix Proteins Viral Proteins Virus Assembly Virus Replication trans-Golgi Network
Insights into herpesvirus assembly from the structure of the pUL7
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
Jun 12, 2020
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread.
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Oct 15, 2021
Naturalism<i>in extremis</i>
Claire White
Oct 08, 2015
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
Multi-Class Cost-Constrained Random Coding for Correlated Sources over the Multiple-Access Channel.
This paper studies a generalized version of multi-class cost-constrained random-coding ensemble with multiple auxiliary costs for the transmission of N correlated sources over an N-user multiple-access channel. For...
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
Tomasz H. Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J. Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A. Stoll, Owen S. Tutt, Stanislava Svobodova, Dmitri I. Svergun, Neil A. Bryant, Janet E. Deane, Andrew E. Firth, Cy M. Jeffries, Colin M. Crump, Stephen C. Graham
Aug 26, 2021
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its...
<i>‘Court’ing Hindu nationalism</i>
Saumya Saxena
Dec 11, 2018
Of
<i>reaflac</i>
and
<i>rapina</i>
Brittany Hanlon
Jan 04, 2023
This article examines the meaning and function of the Old English noun reaflac in two tenth‐century lawsuit documents, Sawyer 877 and Sawyer 1211. It suggests that reaflac was the vernacular counterpart to the Latin terms...
A novel bacteriophage cocktail reduces and disperses <i style="box-sizing: border-box; color: rgb(28, 29, 30); font-family: "Open Sans", icomoon, sans-serif; font-size: 18px;">P</i><i style="box-sizing: border-box; color: rgb(28, 29, 30); font-family: "Open Sans", icomoon, sans-serif; font-size
Diana Alves, Patricia Pérez Esteban, W Kot, Jessica Bean, Thomas Arnot, LH Hansen, Mark Enright, Andrew Jenkins
Jan 01, 2016
Pseudomonas aeruginosa is an opportunistic human pathogen that forms highly stable communities - biofilms, which contribute to the establishment and maintenance of infections. The biofilm state and intrinsic / acquired...
A novel bacteriophage cocktail reduces and disperses <i style="box-sizing: border-box; color: rgb(28, 29, 30); font-family: "Open Sans", icomoon, sans-serif; font-size: 18px;">P</i><i style="box-sizing: border-box; color: rgb(28, 29, 30); font-family: "Open Sans", icomoon, sans-serif; font-size
Diana Alves, Patricia Pérez Esteban, W Kot, Jessica Bean, Thomas Arnot, LH Hansen, Mark Enright, Andrew Jenkins
Jan 01, 2016
Pseudomonas aeruginosa is an opportunistic human pathogen that forms highly stable communities - biofilms, which contribute to the establishment and maintenance of infections. The biofilm state and intrinsic / acquired...
Population biology and phenology of the colour polymorphic damselfly
<i>Ischnura elegans</i>
at its southern range limit in Cyprus
1. Geographically widespread species provide excellent opportunities to investigate how phenotypes change across large‐scale environmental gradients. Temperature is a fundamental environmental variable and an important...
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread.
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Sep 16, 2021
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its...
Published by: PLoS pathogens
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
<i>Ixodes ricinus</i> Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
Jan Kotál, Stéphanie G I Polderdijk, Helena Langhansová, Monika Ederová, Larissa A Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A Huntington, Jindřich Chmelař
Oct 13, 2021
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne...
Published by: International journal of molecular sciences
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Mariana Sacerdoti, Lissy Gross, Andrew M. Riley, Karin Zehnder, Abhijeet Ghode, Sebastian Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, H. Yasmin Godage, Gyles Cozier, Evelyn Sub, Jorg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, Maria Victoria Cappellari, Dmitri Svergun, Melissa A. Grawert, Pedro F. Aramendia, Alejandro E. Leroux, Barry Potter, Carlos J. Camacho, Ricardo M. Biondi
Jun 13, 2023
The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which...
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