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Short inverted repeats contribute to localized mutability in human somatic cells.
Xueqing Zou, Sandro Morganella, Dominik Glodzik, Helen Davies, Yilin Li, Michael R Stratton, Serena Nik-Zainal
Sep 05, 2018
Selected repetitive sequences termed short inverted repeats (SIRs) have the propensity to form secondary DNA structures called hairpins. SIRs comprise palindromic arm sequences separated by short spacer sequences that form the...
The genome as a record of environmental exposure.
Serena Nik-Zainal, Jill E Kucab, Sandro Morganella, Dominik Glodzik, Ludmil B Alexandrov, Volker M Arlt, Annette Weninger, Monica Hollstein, Michael R Stratton, David H Phillips
Sep 10, 2018
Whole genome sequencing of human tumours has revealed distinct patterns of mutation that hint at the causative origins of cancer. Experimental investigations of the mutations and mutation spectra induced by environmental...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 28, 2021
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 27, 2020
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.
Johan Staaf, Dominik Glodzik, Ana Bosch, Johan Vallon-Christersson, Christel Reuterswärd, Jari Häkkinen, Andrea Degasperi, Tauanne Dias Amarante, Lao H Saal, Cecilia Hegardt, Hilary Stobart, Anna Ehinger, Christer Larsson, Lisa Rydén, Niklas Loman, Martin Malmberg, Anders Kvist, Hans Ehrencrona, Helen R Davies, Åke Borg, Serena Nik-Zainal
Sep 10, 2019
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Aug 26, 2020
Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter...
Imperfect integration
Decision-making on the basis of multiple information sources is common. However, to what extent such decisions differ from those with a single source remains unclear. We combined cognitive modelling and neural-mass modelling to...
Experimental Investigation of Ion Formation for Auto-Ignition Combustion in a High-Temperature and High-Pressure Combustion Vessel
One of the main challenges in internal combustion engine design is the simultaneous reduction of all engine pollutants like carbon monoxide (CO), total unburned hydrocarbons (THC), nitrogen oxides (NOx), and soot....
Understanding Cryptocurrency
This exploratory applied study examines the nature and dimensions of cryptocurrency, namely bitcoin, a peer-to-peer network for facilitating digital barter. As the most widely used cryptocurrency, bitcoin has carved itself a...
Published by: IGI Global Scientific Publishing
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Jun 24, 2021
Abstract: Background: Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing...
Experimental Investigation of Ion Formation for Auto-Ignition Combustion in a High-Temperature and High-Pressure Combustion Vessel
One of the main challenges in internal combustion engine design is the simultaneous reduction of all engine pollutants like carbon monoxide (CO), total unburned hydrocarbons (THC), nitrogen oxides (NOx), and soot....
The feet in human--computer interaction
Foot-operated computer interfaces have been studied since the inception of human--computer interaction. Thanks to the miniaturisation and decreasing cost of sensing technology, there is an increasing interest exploring this...
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.
Arie B Brinkman, Serena Nik-Zainal, Femke Simmer, F Germán Rodríguez-González, Marcel Smid, Ludmil B Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J van de Vijver, Anne-Lise Børresen-Dale, Andrea L Richardson, GIlles Thomas, Ivo G Gut, John WM Martens, John A Foekens, Michael R Stratton, Hendrik G Stunnenberg
May 03, 2019
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the...
Helicase Subunit Cdc45 Targets the Checkpoint Kinase Rad53 to Both Replication Initiation and Elongation Complexes after Fork Stalling.
Across eukaryotes, disruption of DNA replication causes an S phase checkpoint response, which regulates multiple processes, including inhibition of replication initiation and fork stabilization. How these events are coordinated...
Cdc45 DNA Damage DNA Replication Rad53 budding yeast checkpoint replisome Cell Cycle Proteins Checkpoint Kinase 2 Congenital Microtia DNA Damage DNA Repair DNA Replication DNA Fungal DNA-Binding Proteins Growth Disorders Humans Micrognathism Mutation Nuclear Proteins Patella Phosphorylation Protein Binding S Phase Cell Cycle Checkpoints Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis.
Dominik Trzupek, Melanie Dunstan, Antony J Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B Rainbow, Dominik Aschenbrenner, Joanne L Jones, Holm H Uhlig, Linda S Wicker, John A Todd, Ricardo C Ferreira
Sep 09, 2020
BACKGROUND: Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and...
AbSeq C-C chemokine receptor type 9 (CCR9) CD4+ T cells CD80 CD86 Immunophenotyping multi-omics regulatory T cells (tregs) Single-cell RNA sequencing (scRNA-seq) Adolescent Adult B7-1 Antigen B7-2 Antigen Female Forkhead Transcription Factors Humans Male Proteome RNA RNA-seq Single-Cell Analysis T-Lymphocytes Regulatory Transcriptome
Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation.
There is evidence to suggest that increasing the level of saturation (that is, the number of sp3-hybridized carbon atoms) of small molecules can increase their likelihood of success in the drug discovery pipeline1. Owing to...
Two decades of tuberculosis surveillance reveal disease spread, high levels of exposure and mortality and marked variation in disease progression in wild meerkats.
Nadine Müller-Klein, Alice Risely, Dominik W Schmid, Marta Manser, Tim Clutton-Brock, Simone Sommer
Sep 02, 2022
3D-CFD RANS Methodology to Predict Engine-Out Emissions with Gasoline-Like Fuel and Methanol for a DISI Engine
Stefania Esposito, Ali Chaychizadeh, Dominik Golc, Raik Hesse, Joachim Beeckmann, Heinz Pitsch
Sep 16, 2022
Renewable fuels, such as bio- and e-fuels, are of great interest for the defossilization of the transport sector. Among these fuels, methanol represents a promising candidate for emission reduction and efficiency increase due...
/dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2213 name=Safety, Risk, Reliability and Quality /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Anomalous sequence of quantum hall liquids revealing a tunable Lifshitz transition in bilayer graphene
Anastasia Varlet, Dominik Bischoff, Pauline Simonet, Kenji Watanabe, Takashi Taniguchi, Thomas Ihn, Klaus Ensslin, Marcin Mucha-Kruczynski, Vladimir I. Fal’ko
Sep 12, 2014
Bilayer graphene is a unique system where both the Fermi energy and the low-energy electron dispersion can be tuned. This is brought about by an interplay between trigonal warping and the band gap opened by a transverse electric...
The feet in human--computer interaction
Foot-operated computer interfaces have been studied since the inception of human--computer interaction. Thanks to the miniaturisation and decreasing cost of sensing technology, there is an increasing interest exploring this...
3D-CFD RANS Methodology to Predict Engine-Out Emissions with Gasoline-Like Fuel and Methanol for a DISI Engine
Stefania Esposito, Ali Chaychizadeh, Dominik Golc, Raik Hesse, Joachim Beeckmann, Heinz Pitsch
Sep 16, 2022
Renewable fuels, such as bio- and e-fuels, are of great interest for the defossilization of the transport sector. Among these fuels, methanol represents a promising candidate for emission reduction and efficiency increase due...
/dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2213 name=Safety, Risk, Reliability and Quality /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Helen Davies, Dominik Glodzik, Sandro Morganella, Lucy R Yates, Johan Staaf, Xueqing Zou, Manasa Ramakrishna, Sancha Martin, Sandrine Boyault, Anieta M Sieuwerts, Peter T Simpson, Tari A King, Keiran Raine, Jorunn E Eyfjord, Gu Kong, Åke Borg, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, Anne-Lise Børresen-Dale, John WM Martens, Paul N Span, Sunil R Lakhani, Anne Vincent-Salomon, Christos Sotiriou, Andrew Tutt, Alastair M Thompson, Steven Van Laere, Andrea L Richardson, Alain Viari, Peter J Campbell, Michael R Stratton, Serena Nik-Zainal
Dec 07, 2020
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic...
Local Structure and Dynamics in Methylammonium, Formamidinium, and Cesium Tin(II) Mixed-Halide Perovskites from 119Sn Solid-State NMR.
Dominik J Kubicki, Daniel Prochowicz, Elodie Salager, Aydar Rakhmatullin, Clare P Grey, Lyndon Emsley, Samuel D Stranks
Apr 06, 2020
Organic-inorganic tin(II) halide perovskites have emerged as promising alternatives to lead halide perovskites in optoelectronic applications. While they suffer from considerably poorer performance and stability in comparison to...
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