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A multi-resolution model is developed to predict two-dimensional spatial fields based on irregularly spaced observations. The radial basis functions at each level of resolution are constructed using a Wendland compactly...

Spatial estimator Kriging Fixed Rank Kriging Sparse Cholesky Dekomposition Multi-resolution

A multi-resolution model is developed to predict two-dimensional spatial fields based on irregularly spaced observations. The radial basis functions at each level of resolution are constructed using a Wendland compactly...

Spatial estimator Kriging Fixed Rank Kriging Sparse Cholesky Dekomposition Multi-resolution

Abstract: An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that...

Original Article covid-19 Cytokine storm immunology Biotechnology Spirulina Anti TNF-α therapy

This Introduction offers a conceptualization of the Indo-Pacific, its islands and their place within the history of science. We argue that Indo-Pacific islands present a remarkable combination of social, political and spatial...

2103 Historical Studies 1601 Anthropology

An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is...

Anti TNF-α therapy Biotechnology covid-19 Cytokine storm immunology Spirulina covid-19 Cell Extracts Cells Cultured cytokine release syndrome Humans In Vitro Techniques MACROPHAGES Monocytes Spirulina

Animals Cell Lineage Ganglia Sensory Neural Crest Neurons Paired Box Transcription Factors Petromyzon Skull

A critical feature of obesity is enhanced insulin secretion from pancreatic β-cells, enabling the majority of individuals to maintain glycaemic control despite adiposity and insulin resistance. Surprisingly, the factors...

adipocyte adipokine BMI body mass index Beta-cell ELISA enzyme-linked immunosorbant assay FABP4 GSIS glucose-stimulated insulin secretion IBMX 3-Isobutyl-1-methylxanthine Insulin Secretion NEFA non-esterified fatty acid obesity SILAC stable-isotope labelling by amino acids in cell culture T2D type 2 diabetes cAMP cyclic-AMP

BACKGROUND AND AIMS: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2...

Administration Oral Aged Diabetes mellitus Type 2 Drug Administration Schedule Drug Therapy Combination Female Glutamine Glycated Hemoglobin Humans Hypoglycemic Agents Male Metformin Middle Aged plasma volume Sitagliptin Phosphate Treatment Outcome

Autistic children who speak few or no words or who have an intellectual disability are the most in need of new understandings and treatments, but the most often left out of the research that can bring these benefits. Researchers...

autism clinical trial inclusion Intellectual Disability intervention Minimally verbal nonverbal Autism spectrum disorder Autistic Disorder Child communication Humans Intellectual Disability Parents

VPS33A drug repurposing endolysosomal acidification Glycosaminoglycan glycosphingolipid trafficking intracellular endocytic trafficking mucopolysaccharidosis proteasome inhibitor substrate reduction therapy Humans Male Endosomes Lysosomes Mutation Mutation Missense Vesicular Transport Proteins

Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This...

coenzyme Q Insulin Insulin Resistance Mitochondria Oxidants Ubiquinone Cell Biology human human biology Medicine MOUSE Adipocytes Adipose Tissue Animals ataxia Humans Insulin Resistance Mice Mitochondria Mitochondrial Diseases Muscle Weakness Muscles Oxidants Sensitivity and Specificity Ubiquinone