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Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
Dorothee Schmid
Jan 01, 0001
MHC class II molecules generally present peptides derived from exogenous antigens after endocytosis. However, biochemical studies have revealed that MHC class II ligands are frequently derived from intracellular proteins after...
Published by: Rockefeller University
The alternative Pharaoh approach
Mark Greco, Dorothee Hoffmann, Anne Dollin, Michael Duncan, Robert Spooner-Hart, Peter Neumann
Jan 01, 0001
Workers from social insect colonies use different defence strategies to combat invaders. Nevertheless, some parasitic species are able to bypass colony defences. In particular, some beetle nest invaders cannot be killed or...
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria.
Zoltán Bánki, Lisa Seekircher, Barbara Falkensammer, David Bante, Helena Schäfer, Teresa Harthaller, Janine Kimpel, Peter Willeit, Dorothee von Laer, Wegene Borena
Sep 26, 2022
In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult...
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria.
Zoltán Bánki, Lisa Seekircher, Barbara Falkensammer, David Bante, Helena Schäfer, Teresa Harthaller, Janine Kimpel, Peter Willeit, Dorothee von Laer, Wegene Borena
Jul 28, 2022
In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult...
The alternative Pharaoh approach
Mark Greco, Dorothee Hoffmann, Anne Dollin, Michael Duncan, Robert Spooner-Hart, Peter Neumann
Jan 01, 0001
Workers from social insect colonies use different defence strategies to combat invaders. Nevertheless, some parasitic species are able to bypass colony defences. In particular, some beetle nest invaders cannot be killed or...
Influence of doctor-patient conversations on behaviours of patients presenting to primary care with new or persistent symptoms
Dorothee Amelung, Katriina L Whitaker, Debby Lennard, Margaret Ogden, Jessica Sheringham, Yin Zhou, Fiona M Walter, Hardeep Singh, Charles Vincent, Georgia Black
Jul 10, 2019
BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants.
Annika Rössler, Antonia Netzl, Ludwig Knabl, Helena Schäfer, Samuel H Wilks, David Bante, Barbara Falkensammer, Wegene Borena, Dorothee von Laer, Derek J Smith, Janine Kimpel
Dec 13, 2022
Several studies have shown that SARS-CoV-2 BA.1 omicron is an immune escape variant. Meanwhile, however, omicron BA.2 and BA.5 became dominant in many countries and replaced BA.1. As both have several mutations compared to BA.1...
Towards a mechanistic understanding of reciprocal drug-microbiome interactions.
Broad-spectrum antibiotics target multiple gram-positive and gram-negative bacteria, and can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the antibiotic activity spectra, and the resistance...
Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools
Peter Willeit, Robert Krause, Bernd Lamprecht, Andrea Berghold, Buck Hanson, Evelyn Stelzl, Heribert Stoiber, Johannes Zuber, Robert Heinen, Alwin Köhler, David Bernhard, Wegene Borena, Christian Doppler, Dorothee von Laer, Hannes Schmidt, Johannes Pröll, Ivo Steinmetz, Michael Wagner
Sep 16, 2021
BACKGROUND: The role of schools in the SARS-CoV-2 pandemic is much debated. We aimed to quantify reliably the prevalence of SARS-CoV-2 infections at schools detected with reverse-transcription quantitative...
BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants.
Annika Rössler, Antonia Netzl, Ludwig Knabl, Helena Schäfer, Samuel H Wilks, David Bante, Barbara Falkensammer, Wegene Borena, Dorothee von Laer, Derek J Smith, Janine Kimpel
Jan 21, 2023
Several studies have shown that SARS-CoV-2 BA.1 omicron is an immune escape variant. Meanwhile, however, omicron BA.2 and BA.5 became dominant in many countries and replaced BA.1. As both have several mutations compared to BA.1...
Seroprevalence of SARS-CoV-2 infection in the Tyrolean district of Schwaz at the time of the rapid mass vaccination in March 2021 following B.1.351-variant outbreak.
Peter Willeit, Janine Kimpel, Hannes Winner, Teresa Harthaller, Helena Schäfer, David Bante, Barbara Falkensammer, Annika Rössler, Lydia Riepler, Cornelia Ower, Magdalena Sacher, Dorothee von Laer, Wegene Borena
Sep 23, 2022
Evaluation of blood and bone marrow in selected canine vector-borne diseases.
Anna S De Tommasi, Domenico Otranto, Tommaso Furlanello, Silvia Tasca, Cinzia Cantacessi, Edward B Breitschwerdt, Dorothee Stanneck, Filipe Dantas-Torres, Gad Baneth, Gioia Capelli, Donato de Caprariis
Feb 17, 2015
Hookworm Treatment for Relapsing Multiple Sclerosis
Radu Tanasescu, Christopher R Tench, Cris S Constantinescu, Gary Telford, Sonika Singh, Nanci Frakich, David Onion, Dorothee P Auer, Bruno Gran, Nikos Evangelou, Yasser Falah, Colin Ranshaw, Cinzia Cantacessi, Timothy P Jenkins, David I Pritchard
Jun 17, 2020
IMPORTANCE: Studies suggest gut worms induce immune responses that can protect against multiple sclerosis (MS). To our knowledge, there are no controlled treatment trials with helminth in MS. OBJECTIVE: To determine whether...
Relationship between neuromelanin and dopamine terminals within the Parkinson's nigrostriatal system.
Antonio Martín-Bastida, Nicholas P Lao-Kaim, Andreas Antonios Roussakis, Graham E Searle, Yue Xing, Roger N Gunn, Stefan T Schwarz, Roger A Barker, Dorothee P Auer, Paola Piccini
Mar 15, 2019
Parkinson’s disease Dopamine transporter Magnetic Resonance Imaging neuromelanin positron emission tomography Case-Control Studies Corpus Striatum Cross-Sectional Studies Dopamine Female Humans Magnetic Resonance Imaging Male Melanins Middle Aged Nerve Endings Neuroimaging Nortropanes Positron-Emission Tomography Substantia Nigra
Stickler Syndrome
Julia Zimmermann, Daniel J Stubbs, Allan J Richards, Philip Alexander, Annie M McNinch, Basil Matta, Martin P Snead
Jan 13, 2020
Adolescent Adult Aged Aged 80 and over Airway Management Anesthesia General Arthritis Child Child Preschool Cleft Palate Cohort Studies Connective Tissue Diseases Female Hearing Loss Sensorineural Humans Infant Infant Newborn Intraoperative Complications Male Middle Aged Pierre Robin Syndrome Retinal Detachment Retrospective Studies Young Adult
Dynamic Prediction of Death in Patients With Tuberculous Meningitis Using Time-updated Glasgow Coma Scale and Plasma Sodium Measurements.
Le Thi Phuong Thao, Marcel Wolbers, A Dorothee Heemskerk, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Ronald B Geskus
Apr 16, 2019
Improved Ribo-seq enables identification of cryptic translation events.
Florian Erhard, Anne Halenius, Cosima Zimmermann, Anne L'Hernault, Daniel J Kowalewski, Michael P Weekes, Stefan Stevanovic, Ralf Zimmer, Lars Dölken
May 04, 2018
Ribosome profiling has been used to predict thousands of short open reading frames (sORFs) in eukaryotic cells, but it suffers from substantial levels of noise. PRICE (https://github.com/erhard-lab/price) is a computational...
Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.
Peter Willeit, Benoît Bernar, Christoph Zurl, Mariam Al-Rawi, Andrea Berghold, David Bernhard, Wegene Borena, Christian Doppler, Reinhold Kerbl, Alwin Köhler, Robert Krause, Bernd Lamprecht, Johannes Pröll, Hannes Schmidt, Ivo Steinmetz, Evelyn Stelzl, Heribert Stoiber, Dorothee von Laer, Johannes Zuber, Thomas Müller, Volker Strenger, Michael Wagner
Sep 27, 2021
This study evaluates the performance of the antigen-based anterior nasal screening programme implemented in all Austrian schools to detect SARS-CoV-2 infections. We combined nationwide antigen-based screening data obtained in...
Adaptive laboratory evolution of microbial co‐cultures for improved metabolite secretion
Dimitrios Konstantinidis, Filipa Pereira, Eva‐Maria Geissen, Kristina Grkovska, Eleni Kafkia, Paula Jouhten, Yongkyu Kim, Saravanan Devendran, Michael Zimmermann, Kiran Raosaheb Patil
Aug 11, 2021
EMBO41 EMBO21 EMBO23 article ARTICLES coevolution experimental evolution Metabolic cooperation multi‐omics vitamin secretion
Published by: Molecular Systems Biology
Towards a variational Jordan-Lee-Preskill quantum algorithm
Abstract
Rapid developments of quantum information technology show promising opportunities for simulating quantum field theory in near-term quantum devices. In this work, we...
Adaptive laboratory evolution of microbial co-cultures for improved metabolite secretion.
Dimitrios Konstantinidis, Filipa Pereira, Eva-Maria Geissen, Kristina Grkovska, Eleni Kafkia, Paula Jouhten, Yongkyu Kim, Saravanan Devendran, Michael Zimmermann, Kiran Raosaheb Patil
Sep 24, 2021
Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as...
Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.
Nguyen TT Thuong, Dorothee Heemskerk, Trinh TB Tram, Le TP Thao, Lalita Ramakrishnan, Vu TN Ha, Nguyen D Bang, Tran TH Chau, Nguyen H Lan, Maxine Caws, Sarah J Dunstan, Nguyen VV Chau, Marcel Wolbers, Nguyen TH Mai, Guy E Thwaites
Nov 21, 2018
BACKGROUND: Tuberculous meningitis (TBM) is the most devastating form of tuberculosis, yet very little is known about the pathophysiology. We hypothesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which...
Leukotriene A4 hydrolase genotype Cytokines inflammatory response survival. Tuberculous meningitis Adolescent Adult Aged Aged 80 and over Antiretroviral Therapy Highly Active Antitubercular Agents Cerebrum Cytokines Epoxide Hydrolases Female Genotype HIV Infections Humans Inflammation Kaplan-Meier Estimate Leukocytes Male Middle Aged Multivariate Analysis Mycobacterium tuberculosis Polymorphism Single Nucleotide Proportional Hazards Models Survival Analysis Tuberculosis Meningeal Young Adult
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.
Dor Zaguri, Manuela R Zimmermann, Georg Meisl, Aviad Levin, Sigal Rencus-Lazar, Tuomas PJ Knowles, Ehud Gazit
Nov 03, 2021
The formation of ordered protein and peptide assemblies is a phenomenon related to a wide range of human diseases. However, the mechanism of assembly at the molecular level remains largely unknown. Minimal models enable the...
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