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The Privileged Life of a Theoretical Observer.
Douglas Gough
Aug 17, 2022
This is a summary of my scientific career, biased by my personal view of events and unashamedly concentrating on those aspects of some of the scientific developments to which I have contributed. A selective unbiased alternative...
The Privileged Life of a Theoretical Observer
Abstract This is a summary of my scientific career, biased by my personal view of events and unashamedly concentrating on those aspects of some of the scientific developments to which I have...
Douglas Gough
Jul 26, 2022
GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
Leanne Li, Qiqun Zeng, Arjun Bhutkar, José A Galván, Eva Karamitopoulou, Daan Noordermeer, Mei-Wen Peng, Alessandra Piersigilli, Aurel Perren, Inti Zlobec, Hugh Robinson, M Luisa Iruela-Arispe, Douglas Hanahan
Jun 28, 2018
Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here...
FMRP GKAP/Dlgap1 GluN2b/NR2b/Grin2b HSF1 MK801 NMDAR RIP1Tag2 cancer modifier glutamate receptor Memantine pancreatic ductal adenocarcinoma (PDAC) Animals Antineoplastic Agents Carcinoma Neuroendocrine Carcinoma Pancreatic Ductal Cell Line Tumor Fragile X Mental Retardation Protein Gene Expression Profiling Gene Expression Regulation Neoplastic Heat Shock Transcription Factors Humans Mice Neoplasm Invasiveness Neoplasm Transplantation Pancreatic Neoplasms Prognosis Receptors N-Methyl-D-Aspartate SAP90-PSD95 Associated Proteins Sequence Analysis RNA Signal Transduction Survival Analysis
Corrections to: Use of the BOADICEA Web Application in clinical practice
Anne Brédart, Jean-Luc Kop, Antonis C Antoniou, Alex P Cunningham, Antoine de Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Jan 23, 2018
The article "Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries" written by Anne Brédart · Jean‑Luc Kop · Antonis C. Antoniou · Alex P. Cunningham · Antoine De Pauw ·Marc...
Synaptic proximity enables NMDAR signalling to promote brain metastasis.
Qiqun Zeng, Iacovos P Michael, Peng Zhang, Sadegh Saghafinia, Graham Knott, Wei Jiao, Brian D McCabe, José A Galván, Hugh PC Robinson, Inti Zlobec, Giovanni Ciriello, Douglas Hanahan
Dec 23, 2020
Optimization of Production Decisions Under Resource Constraints and Community Priorities
Tetyana Nestorenko, Oleksandr Nestorenko, Mangirdas Morkunas, Artiom Volkov, Tomas Balezentis, Dalia Streimikiene, Jinyang Cai
Jan 01, 2022
The current paper proposes analytical solution of the problem of optimal allocation of resources in the game of two parties, based on the production function of Cobb-Douglas with constant returns under changing scale of...
Published by: IGI Global Scientific Publishing
Premiere of ''Messiah on the Frigidaire'' Set for March 28
Winthrop University
Jan 01, 0001
"Messiah on the Frigidaire" will run March 28-31 at 8 p.m. and April 1 at 2 p.m. in Johnson Theatre. Meagan Douglas, a senior theater major, will direct John Culbertson's play.
Published by: Winthrop University
Faculty Awards to Be Given at Graduate and Undergraduate Commencements
Winthrop University
Jan 01, 0001
President Anthony DiGiorgio will bestow the Distinguished Professor Award on Douglas Eckberg, professor of sociology, and the Outstanding Junior Professor Award on Courtney Starrett, assistant professor of fine arts. DiGiorgio...
Published by: Winthrop University
The Grizzly, September 14, 2023
Marie Sykes, Erin Corcoran, Kate Horan, Amelia Kunko, Andrew J. Perez, Mairead McDermott, Renie Christensen, Hannah Conley, Sean McGinley, Georgia Gardner, Adam Denn, Dominic Minicozzi
Jan 01, 0001
Good Samaritan Policy Changes: Good Ideas? Changes Across Wismer Student Handbook Changes Letter From the Editor Hello From the News Editor ODA's Peer Mentor Program Meet SGA President: Ben Douglas Opinions: Upper...
Ursinus College Collegeville Pennsylvania newspaper student handbook Good Samaritan Policy student government Wismer dining hall Office of Disability and Access Ben Douglas Soccer Football cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Early Post-Partum Changes in the Murine Heart
Matthew Douglas
Jan 01, 0001
The heart is arguably the most important organ in the body, supporting all other organ systems. Therefore, it must be able to adapt to change. One way the heart handles changes in pressure and/or volume is by enlarging its...
Published by: Ursinus College
Control into infinitival relatives
This article focuses on a novel English construction involving control and infinitival relatives. Examples such as this is John's book to read have a head noun (book )...
JAMIE DOUGLAS
Jun 26, 2018
Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme
Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it the principal target in the...
Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme
Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it the principal target in the...
Interview with Lanford Brackett
Lanford Brackett
Jan 01, 0001
In his October 9, 2009 interview with Anna Douglas, Lanford Brackett describes his assignment overseas in Samoa. Brackett also shares the story of how he won the Silver Star medal and the recognition he received afterward....
Marine Corps Pacific Samoa Japanese New Zealand Invasion of Bougainville food home front rations Oral History
Published by: Winthrop University
Promoting cooperation in innovation ecosystems
Abstract: We investigate whether public support for innovation increases the propensity of SMEs in traditional manufacturing industries to cooperate for innovation—in particular, for incremental innovation—with other firms and...
Sims to Address Northwestern District Alumnae Association
Winthrop News Service
Jan 01, 0001
Winthrop College Alumnae Association Northwestern District consisted of the counties of Abbeville, Anderson, Greenville, Greenwood, McCormick, Oconee, and Pickens in South Carolina. The meeting took place on November 2, 1946 in...
Published by: Winthrop University
Investigating Epistemic Stances in Game Play with Data Mining
In this paper, techniques of statistical computing were applied to data logs to investigate the patterns in students' play of The Fuzzy Chronicles, and how these patterns relate to learning outcomes with regards to Newtonian...
Published by: IGI Global Scientific Publishing
The adaptive designs CONSORT extension (ACE) statement
Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, Douglas G Altman, ACE Consensus Group
Jun 17, 2021
Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of...
Risk of neuropsychiatric and cardiovascular adverse events following treatment with varenicline and nicotine replacement therapy in the UK Clinical Practice Research Datalink
Kyla H Thomas, Neil M Davies, Amy E Taylor, Gemma M J Taylor, David Gunnell, Richard M Martin, Ian Douglas
Jun 30, 2021
BACKGROUND AND AIMS: Varenicline and nicotine replacement therapy (NRT) are the most commonly used medications to quit smoking. Given their widespread use, monitoring adverse risks remains important. This study aimed to...
Quantifying Water Diffusivity and Metamorphic Reaction Rates Within Mountain Belts, and Their Implications for the Rheology of Cratons
The distribution of rheologically strong cratons, and their weakening by metamorphic hydration reactions, is of fundamental importance for understanding first-order strength contrasts within the crust, and the resulting controls...
Risk accuracy of type 2 diabetes in middle aged adults
OBJECTIVE: To identify the proportion of individuals with an accurate perception of their risk of type 2 diabetes (T2D) prior to, immediately after and eight weeks after receiving a personalised risk estimate. Additionally, we...
Intentional and Responsible
Unintended consequences of technology are ubiquitous and often negative. Certain communities, the Amish for example, have minimized these consequences by understanding and agreeing upon the social values they seek to preserve...
Published by: IGI Global Scientific Publishing
Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme
Kate M. Larmuth, Geoffrey Masuyer, Ross G. Douglas, Sylva L. Schwager, K. Ravi Acharya, Edward D. Sturrock
Mar 01, 2016
Angiotensin-1-converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities. Here we report kinetic parameters of five different forms of human...
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