Search
Results: 37
Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements.
Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
Chinese hamster ovary (CHO) cells are used for the production of the majority of biopharmaceutical drugs, and thus have remained the standard industry host for the past three decades. The amino acid composition of the medium...
Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations
The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products. The...
Metabolic modeling to identify engineering targets for Komagataella phaffii
Genome-scale metabolic models are valuable tools for the design of novel strains of industrial microorganisms, such as Komagataella phaffii (syn. Pichia pastoris). However, as is the case for many industrial microbes, there is...
Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism.
BACKGROUND: Rapamycin is a potent inhibitor of the highly conserved TOR kinase, the nutrient-sensitive controller of growth and aging. It has been utilised as a chemotherapeutic agent due to its anti-proliferative properties and...
Handling variability and incompleteness of biological data by flexible nets
Mathematical models that combine predictive accuracy with explanatory power are central to the progress of systems and synthetic biology, but the heterogeneity and incompleteness of biological data impede our ability to...
Recombinant expression of insoluble enzymes in Escherichia coli
Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations
The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products. The...
Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene.
Retail and Place Attractiveness
The opponents of big‐box entry argue that large retail establishments generate a variety of negative externalities. The advocates, on the contrary, argue that access to a large retail market not only delivers direct economic...
Published by: Geographical Analysis
Metaheuristic approaches in biopharmaceutical process development data analysis.
Nishanthi Gangadharan, Richard Turner, Ray Field, Stephen G Oliver, Nigel Slater, Duygu Dikicioglu
May 20, 2019
How yeast re-programmes its transcriptional profile in response to different nutrient impulses.
Duygu Dikicioglu, Erkan Karabekmez, Bharat Rash, Pinar Pir, Betul Kirdar, Stephen Oliver
Feb 23, 2012
Metaheuristic approaches in biopharmaceutical process development data analysis
Nishanthi Gangadharan, Richard Turner, Ray Field, Stephen G. Oliver, Nigel Slater, Duygu Dikicioglu
Jun 06, 2020
Abstract: There is a growing interest in mining and handling of big data, which has been rapidly accumulating in the repositories of bioprocess industries. Biopharmaceutical industries are no exception; the implementation of...
A heuristic approach to handling missing data in biologics manufacturing databases.
Jeanet Mante, Nishanthi Gangadharan, David J Sewell, Richard Turner, Ray Field, Stephen G Oliver, Nigel Slater, Duygu Dikicioglu
Jan 30, 2019
Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis.
Elif Dereli Eke, Kazim Yalcin Arga, Duygu Dikicioglu, Serpil Eraslan, Emir Erkol, Arzu Celik, Betul Kirdar, Barbara Di Camillo
May 03, 2019
Target of rapamycin (TOR) is a major signaling pathway and regulator of cell growth. TOR serves as a hub of many signaling routes, and is implicated in the pathophysiology of numerous human diseases, including cancer, diabetes...
Biomarkers caffeine Drug targets multiomics network-based analysis target of rapamycin (TOR) signaling Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Proteomics Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction TOR Serine-Threonine Kinases
Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J Enright, Jeroen Krijgsveld, Christophe Lancrin
Nov 20, 2017
The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and progenitor cells during embryogenesis. As TGFβ...
Animals Cell Differentiation Cell Movement Cell Transdifferentiation Colony-Forming Units Assay Endothelial Cells Extracellular Matrix Gene Expression Profiling Gene Expression Regulation Developmental HMGB Proteins Hematopoiesis Hematopoietic Stem Cells Mice Neovascularization Physiologic SOXF Transcription Factors Signal Transduction Transcriptome Transforming Growth Factor beta
Transcriptional regulation of the genes involved in protein metabolism and processing in Saccharomyces cerevisiae.
Duygu Dikicioglu, Daniel JH Nightingale, Valerie Wood, Kathryn S Lilley, Stephen G Oliver
Feb 11, 2019
Topological analysis of large networks, which focus on a specific biological process or on related biological processes, where functional coherence exists among the interacting members, may provide a wealth of insight into...
Network analysis protein metabolic process Protein Processing Proteomics Transcriptional regulation Yeast Gene Expression Regulation Fungal Gene Regulatory Networks Protein Processing Post-Translational Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors Transcription Genetic
The Carbon-Sulfur Link in the Remineralization of Organic Carbon in Surface Sediments
Harold J. Bradbury, Alexandra V. Turchyn, Adam Bateson, Gilad Antler, Angus Fotherby, Jennifer L. Druhan, Mervyn Greaves, Duygu S. Sevilgen, David A. Hodell
May 20, 2021
Here we present the carbon isotopic composition of dissolved inorganic carbon (DIC) and the sulfur isotopic composition of sulfate, along with changes in sulfate concentrations, of the pore fluid collected from a series of...
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Morgan Oatley, Özge Vargel Bölükbası, Valentine Svensson, Maya Shvartsman, Kerstin Ganter, Katharina Zirngibl, Polina V Pavlovich, Vladislava Milchevskaya, Vladimira Foteva, Kedar N Natarajan, Bianka Baying, Vladimir Benes, Kiran R Patil, Sarah A Teichmann, Christophe Lancrin
Mar 05, 2020
The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The intermediary steps of this process are unclear, in...
Animals Aorta arteries Biomarkers Cell Cycle Citric Acid Cycle Computational Biology Core Binding Factor Alpha 2 Subunit Down-Regulation Endothelium Glycolysis Gonads Hematopoiesis Hematopoietic Stem Cells Hyaluronan Receptors Hyaluronic Acid Mesonephros Mice Mice Inbred C57BL Mice Knockout Transcriptome Transforming Growth Factor beta
|
|< |
< |
1 |